| Spartan Chamber Limited | Arts & recreation | 2018 |
| Spherecraft Ltd | Wholesale & retail | 2024 |
| Spink Translations Ltd | Professional & scientific | 2019 |
| Sponsor Licence & Visas Group Ltd | Professional & scientific | 2024 |
| SPW Global Training Limited | Arts & recreation | 2023 |
| SQD Away Limited | Construction | 2023 |
| SR Scaffolding Services Limited | Construction | 1998 |
| SRH Property Services Ltd | Real estate | 2025 |
| SRK Scaffolding and Industrial Services Ltd | Construction | 2000 |
| ST Decumans Road Watchet Limited | Households | 2007 |
| Stanbury Trees & Fencing Ltd | Construction | 2018 |
| Stanley Properties Limited | | 2023 |
| Stanyard Facades Limited | Construction | 2017 |
| Stanyard Properties Limited | Real estate | 2024 |
| Star Sports Development Ltd | Arts & recreation | 2011 |
| State of Fury Limited | Arts & recreation | 2005 |
| Station Mills Holdings Limited | Manufacturing | 2026 |
| Stoat Group Limited | Agriculture & fishing | 2008 |
| Stone Alliance Ltd | Financial services | 2021 |
| Stone Alliance Trustee Limited | Other services | 2023 |
| Storith Consulting Limited | Professional & scientific | 2011 |
| Storly Ltd | Administrative & support | 2026 |
| Stovold and Pogue Limited | Wholesale & retail | 2013 |
| Stravex Holdings Ltd | Financial services | 2025 |
| SUB Rosa Global Ltd | Information & communication | 2015 |
| Sunnydee Traders Ltd | Wholesale & retail | 2020 |
| Super Kids Therapy Ltd | Health & social care | 2020 |
| Supernormal Group Ltd | Professional & scientific | 2010 |
| Superstar Studio's Ltd | Arts & recreation | 2019 |
| Svsv Investments Limited | Financial services | 2019 |
| Swallowfield Consumer Products Limited | Administrative & support | 1996 |
| Swanns Carpet and Upholstery Cleaning Ltd | Administrative & support | 2018 |
| Swim England South West Limited | Education | 2020 |
| Symmons Madge Associates Limited | Professional & scientific | 2008 |
| Synertec (Holdings) Limited | Financial services | 2019 |
| Synertec Limited | Information & communication | 1999 |
| T G Flooring (South West) Limited | Construction | 2016 |
| T M Norris Transport Ltd | Transport & logistics | 2014 |
| T&S Artificial Grass and Landscaping Ltd | Administrative & support | 2022 |
| T&T Development 2014 Ltd | Construction | 2014 |
| T.G (SW) Ltd | Professional & scientific | 2024 |
| T1 Fitness Gym Ltd | Arts & recreation | 2024 |
| Tamburello Consulting Ltd | Information & communication | 2014 |
| Tasc Travel Ltd | Administrative & support | 2016 |
| Tate (U.K.) Limited | Professional & scientific | 1987 |
| Taunton Model Engineers | Professional & scientific | 1995 |
| Taunton Windows and Conservatories (SW) Ltd | Construction | 2017 |
| Taurus Projects SW Ltd | Manufacturing | 2025 |
| Tcrd Ltd | Health & social care | 2019 |
| Technical Construction Supplies Ltd | Wholesale & retail | 2009 |
| Technical Vehicle Repairs and Servicing (South West) Limited | Wholesale & retail | 2012 |
| Telford Consumer Products Limited | Manufacturing | 1999 |
| Tendovend Ltd | Wholesale & retail | 2024 |
| Tenev Homes Ltd | Construction | 2019 |
| Terraflora Consulting Limited | Extraterritorial | 2017 |
| Textureblast Limited | Construction | 2006 |
| That Group Company Ltd | Administrative & support | 2024 |
| THE Book-Ends Shop Ltd | Wholesale & retail | 2022 |
| THE Care Partnership (South West) Ltd | Health & social care | 2017 |
| THE CIP Project CIC | Other services | 2020 |
| THE Curiosity Cabinetx Ltd | Wholesale & retail | 2023 |
| THE Dartmoor Shepherd Ltd | Agriculture & fishing | 2016 |
| THE Dorset & Somerset Air Ambulance Charity | Professional & scientific | 1999 |
| THE Festive Lighting Company Limited | Wholesale & retail | 2000 |
| THE Film School of Notting Hill Ltd | Administrative & support | 2025 |
| THE Great British Cloth Company Limited | Manufacturing | 2015 |
| THE Incredible Window Cleaning Company Yeovil Ltd | Administrative & support | 2021 |
| THE New Martlet Limited | Hospitality | 2025 |
| THE OIL HUT Ltd | Manufacturing | 2015 |
| THE Old Cleve Stables Wellington Limited | Households | 2006 |
| THE Ostler Consulting Company Limited | Information & communication | 2011 |
| THE Pantry House Limited | Manufacturing | 2020 |
| THE Plantside Company Limited | Hospitality | 2019 |
| THE Practical Training Hub Ltd | Professional & scientific | 2016 |
| THE Priory House Flats Management Limited | Households | 1989 |
| THE Project DOC Ltd | Information & communication | 2024 |
| THE Sanctuary Bar & Lounge Ltd | Hospitality | 2025 |
| THE Talent Providers Limited | Administrative & support | 2011 |
| THE TIB Bros Ltd | Wholesale & retail | 2022 |
| THE Trauma Regulation Board Ltd | Health & social care | 2017 |
| THE Tyre Warehouse (SW) Ltd | Wholesale & retail | 2018 |
| THE Wellington School Foundation | Education | 2004 |
| THE Wyndham Arms Public House LLP | | 2024 |
| Theorock Estates Ltd | Real estate | 2025 |
| Thomas Facades Limited | Construction | 2019 |
| Thomas Penn Partnership Ltd | Financial services | 2007 |
| Thomas Redwood Builders Limited | Construction | 2004 |
| Thorne Flooring Ltd | Construction | 2025 |
| Throw Down Ltd | Professional & scientific | 2017 |
| Tile & Bath World (SW) Ltd | Wholesale & retail | 2011 |
| Tile and Bath (Chelston) Ltd | Construction | 2026 |
| Tilford Security Risk Consultancy Ltd | Administrative & support | 2025 |
| TIM Gittins Limited | Hospitality | 2009 |
| TIM Potter SON and Daughter (Family Butchers) Limited | Wholesale & retail | 2008 |
| TL & B Holdings Limited | Financial services | 2023 |
| TLC Garage Services Limited | Wholesale & retail | 2020 |
| TLC Taxis Limited | Transport & logistics | 2018 |
| TLR Kitchens Ltd | Manufacturing | 2025 |
| TMS Coaching Ltd | Education | 2023 |
| TMT RO Ltd | Transport & logistics | 2023 |