| Smizm Limited | Transport & logistics | 2021 |
| SN Local Convenience Store Ltd | Wholesale & retail | 2019 |
| Snack Swift Ltd | Hospitality | 2024 |
| Snug AS a BUG and Sons Ltd | Construction | 2025 |
| Sofa Kingdom Ltd | Wholesale & retail | 2019 |
| Softingenious Limited | Wholesale & retail | 2024 |
| Sohl Property Services (UK) Limited | Real estate | 2006 |
| Sokopo Ltd | Transport & logistics | 2019 |
| Solartech Electrical Ltd | Construction | 2026 |
| Solid Base Maintenance Ltd | Administrative & support | 2020 |
| Solly Street Capital Ltd | Real estate | 2023 |
| Somers Handling Limited | Professional & scientific | 2025 |
| Somerset Contractors Ltd | Construction | 2021 |
| Somerset Roofing & Building Ltd | Construction | 2025 |
| Somita Khesani Ltd | Health & social care | 2024 |
| Sondh Trading Ltd | Wholesale & retail | 2025 |
| Sonny Flooring Ltd | Construction | 2019 |
| Sony Imports Limited | Wholesale & retail | 2023 |
| South Meets West Ltd | Health & social care | 2023 |
| Sowkot Sales Ltd | Wholesale & retail | 2025 |
| SPACE4CONSULTING Limited | Administrative & support | 2011 |
| Spareroom 2019 Ltd | Hospitality | 2019 |
| Spareroom 2024 Limited | Transport & logistics | 2024 |
| Spate Consultancy Limited | Information & communication | 2022 |
| Specialist Windows Ltd | Manufacturing | 2024 |
| Spice House ISA Ltd | Hospitality | 2026 |
| Spices Restaurant & Takeaway Ltd | Hospitality | 2025 |
| Spichlerz Ltd | Wholesale & retail | 2025 |
| Spindle by Sisters Limited | Wholesale & retail | 2021 |
| Spingere Ltd | Hospitality | 2025 |
| Spintec Metal Spinning Limited | Manufacturing | 2010 |
| Springfield Electrical and Security Services Limited | Construction | 2023 |
| Springhill Developments Limited | Real estate | 2001 |
| SPS Sales & Engineering Limited | Wholesale & retail | 2012 |
| Srmt Properties Ltd | Real estate | 2024 |
| SRS Fire & Safety Ltd | Construction | 2022 |
| SS E-Convenience Ltd | Extraterritorial | 2023 |
| SS Groups IND Ltd | Hospitality | 2021 |
| SSB Builders Limited | Construction | 2017 |
| SSC Group Ltd | Construction | 2022 |
| SSG Employ Ltd | Administrative & support | 2025 |
| SSJ Locum Ltd | Professional & scientific | 2019 |
| SSP Services Limited | Other services | 2018 |
| Sspi Limited | Professional & scientific | 2016 |
| Ssrmg Limited | Wholesale & retail | 2025 |
| Sssg Haulage Ltd | Transport & logistics | 2025 |
| SSV Property Developments Ltd | Construction | 2026 |
| ST Alex Support Limited | Health & social care | 2015 |
| Staffordshire Sash Windows Ltd | Construction | 2019 |
| Stainless Metric Stock Limited | Administrative & support | 1980 |
| Staircase Upgrades Ltd | Manufacturing | 2023 |
| Stangeorge Cons Ltd | Construction | 2019 |
| Stanley Developements Limited | Construction | 2002 |
| Stanton Control Systems Ltd | Construction | 2023 |
| Star Communication SPL Ltd | Wholesale & retail | 2024 |
| Star Precision Tools Limited | Manufacturing | 2003 |
| Starjump Productions Limited | Extraterritorial | 2016 |
| Starline Accountancy Ltd | Professional & scientific | 2022 |
| Stateblock Ltd | Energy | 2025 |
| Station Street Motors Ltd | Wholesale & retail | 2021 |
| Steak an Bake Ltd | Hospitality | 2023 |
| Still Waters Properties Limited | Wholesale & retail | 1984 |
| Stone Cross Holdings WM Ltd | Financial services | 2024 |
| Stone Cross Roofing Ltd | Construction | 2025 |
| Stone Cross Scaffolding Ltd | Construction | 2018 |
| Stonecote Ltd | Other services | 2020 |
| Stonehouse Construction Limited | Construction | 2025 |
| STP Ventures Ltd | Professional & scientific | 2025 |
| STR Lines Limited | Wholesale & retail | 2016 |
| Strategic Legal Ltd | Other services | 2021 |
| Strategic Legal Practice Ltd | Professional & scientific | 2016 |
| Strategic Legal Services Ltd | Other services | 2013 |
| Strategy Performance Limited | Information & communication | 2012 |
| Streamline Your Business Ltd | Administrative & support | 2024 |
| Streetly Damp Proofing and Plastering Contractors Limited | Construction | 2006 |
| Streetwise Servicing Ltd | Wholesale & retail | 2026 |
| Structural Design (Midlands) Limited | Professional & scientific | 2026 |
| Structural Design Consultancy Limited | Professional & scientific | 2017 |
| Structure Dynamics Ltd | Information & communication | 2019 |
| Strut Direct Limited | Manufacturing | 2000 |
| Strutfoot Limited | Extraterritorial | 2016 |
| STU Elvins Services Ltd | Transport & logistics | 2016 |
| Studbolt Manufacturing Limited | Manufacturing | 2003 |
| Style Construction Services Ltd | Construction | 2023 |
| Sublime Creative Ltd | Professional & scientific | 2011 |
| Sukh Builders Ltd | Construction | 2023 |
| Sukh Chattha Construction Ltd | Construction | 2020 |
| Suki Shocker Interior Design Ltd | Professional & scientific | 2018 |
| Sultan Trefy Limited | Wholesale & retail | 2026 |
| Sultan Tyre Service Ltd | Wholesale & retail | 2024 |
| Sultans Property Ltd | Real estate | 2023 |
| Suman UK Properties Limited | Real estate | 2020 |
| Sumo Engineering Limited | Professional & scientific | 2025 |
| Sunkist Tanning Ltd | Other services | 2024 |
| Sunny Park Club Ltd | Hospitality | 2026 |
| Sunrise Dryliner & Interior Finishing Ltd | Construction | 2023 |
| Sunset Plates Ltd | Other services | 2025 |
| Supafit Bodywork Ltd | Wholesale & retail | 2020 |
| Supaflo Engineering Limited | Wholesale & retail | 2000 |
| Super Jade Garden Ltd | Hospitality | 2024 |