| Smith & Nephew Medical Fabrics Limited | Professional & scientific | 1955 |
| Smith & Nephew Nominee Company Limited | Professional & scientific | 1989 |
| Smith & Nephew Nominee Services Limited | Professional & scientific | 1931 |
| Smith & Nephew Orthopaedics Limited | Manufacturing | 1996 |
| Smith & Nephew PLC | Manufacturing | 1937 |
| Smith & Nephew Raisegrade Limited | Professional & scientific | 1991 |
| Smith & Nephew Rareletter Limited | Professional & scientific | 1991 |
| Smith & Nephew Trading Group Limited | Professional & scientific | 1961 |
| Smith & Nephew UK Executive Pension Scheme Trustee Limited | Financial services | 2010 |
| Smith & Nephew UK Limited | Professional & scientific | 2002 |
| Smith & Nephew UK Pension Fund Trustee Limited | Financial services | 2010 |
| Smith & Nephew USD Limited | Administrative & support | 1973 |
| Smith & Nephew USD One Limited | Administrative & support | 2016 |
| Smith and Sons Travel, Leisure, Care Ltd | Health & social care | 2025 |
| Smith Harrison LLP | | 2011 |
| Smith's Crossing Ltd | Professional & scientific | 2006 |
| Smjh Associates Limited | Hospitality | 2026 |
| Smls Medical Ltd | Health & social care | 2025 |
| Smollan UK Ltd | Professional & scientific | 2022 |
| SMS Watford Ltd | Professional & scientific | 2016 |
| Smug Oak Lane Limited | Real estate | 2022 |
| Smyrna Technology Limited | Wholesale & retail | 2021 |
| SN Management Ltd | Professional & scientific | 2020 |
| Snacks Van Ltd | Hospitality | 2017 |
| Snap IT Consultancy Limited | Information & communication | 2023 |
| Snap TV Limited | Information & communication | 2012 |
| Snapfix Appliances Ltd | Other services | 2025 |
| Snazz Ltd | Manufacturing | 2019 |
| SND Network Communications Ltd | Construction | 2014 |
| Snells Wood Court Management Limited | Households | 1984 |
| Sneram Limited | Real estate | 2026 |
| Snesan Ltd | Hospitality | 2025 |
| SNF Real Estates Ltd | Real estate | 2026 |
| SNM Finance Ltd | Financial services | 2024 |
| Snooker Sports Limited | Arts & recreation | 1983 |
| Snow Valley Ltd. | Information & communication | 2015 |
| SNP Builders Ltd | Construction | 2025 |
| SNS Support Group C.I.C. | Real estate | 2019 |
| SO Pizza Ltd | Hospitality | 2024 |
| Soar Capital Limited | Financial services | 2026 |
| Sobescorp Ltd | Other services | 2023 |
| Socha Properties Ltd | Construction | 2022 |
| Social Case Management Solutions Ltd | Health & social care | 2025 |
| Social Dhaba Holdings Limited | Financial services | 2018 |
| Social Dhaba Limited | Hospitality | 2018 |
| Social Health Advisory Ltd | Professional & scientific | 2025 |
| Social Ready Ltd | Households | 2025 |
| Socialicity Gaming Limited | Arts & recreation | 2019 |
| Socialicity Group Ltd | Information & communication | 2012 |
| Socium Total Talent Management Limited | Administrative & support | 2019 |
| Socius LAB Ltd | Professional & scientific | 2023 |
| Socomp Ltd | Arts & recreation | 2025 |
| Sofia Painting and Decorating Ltd | Construction | 2026 |
| Sofibel Food & Beverage Limited | Wholesale & retail | 2019 |
| Sofibel Ltd | Wholesale & retail | 2012 |
| Sofibel Property Ltd | Construction | 2015 |
| Soft Commodity Profiling Ltd. | Professional & scientific | 2017 |
| Softcart Ltd | Wholesale & retail | 2026 |
| Softcloud Solutions Ltd | Information & communication | 2023 |
| Softeck Limited | Information & communication | 2015 |
| Softimulti Ltd | Information & communication | 2025 |
| Softpure Water Ltd | Construction | 2025 |
| Softsource Info Ltd | Information & communication | 2024 |
| Software Design Systems Ltd | Information & communication | 2015 |
| SOH Actuarial Ltd | Financial services | 2018 |
| Soham for ALL | Health & social care | 2009 |
| Soho Medical Limited | Manufacturing | 2020 |
| Soho Music Publishing Ltd | Information & communication | 2015 |
| Soho SIP Ltd | Hospitality | 2024 |
| Sohobyte Ltd | Information & communication | 2026 |
| SOI Vang Ltd | Wholesale & retail | 2019 |
| Sojoh Limited | Professional & scientific | 2019 |
| Sojourn Hotels (Wembley) LLP | | 2012 |
| Sojourn Hotels (York) LLP | | 2014 |
| SOL Glass Ltd | Construction | 2024 |
| SOL Tiling Ltd | Construction | 2021 |
| Solace Psychological Therapies Ltd | Health & social care | 2018 |
| Solandlu Limited | Other services | 2022 |
| Solano Travel Ltd | Administrative & support | 2025 |
| Solar Court (Finchley) Management Limited | Real estate | 1969 |
| SOLAR4GOOD Commercial UK Limited | Construction | 2026 |
| Solas Consulting Limited | Professional & scientific | 2019 |
| Solastech Ltd | Information & communication | 2015 |
| Solbear Ltd | Financial services | 2022 |
| Sole Bliss Consulting Limited | Professional & scientific | 2024 |
| Sole Bliss Holdings Ltd | Financial services | 2026 |
| Sole Bliss Limited | Wholesale & retail | 2010 |
| Solid Enterprise Watford Limited | Wholesale & retail | 2011 |
| Solid Quality Solutions Limited | Information & communication | 2007 |
| Solid Rock Consulting Emea Ltd | Administrative & support | 2025 |
| Solid Water Ltd | Professional & scientific | 2021 |
| Solinovare Ltd | Manufacturing | 2021 |
| Soliton Limited | Health & social care | 1990 |
| Solle Limited | Extraterritorial | 2000 |
| Sollers Enterprise Ltd | Professional & scientific | 2020 |
| Sollershott Hall Management Limited | Households | 1995 |
| Solo 7 UK Sales Limited | Administrative & support | 2018 |
| Solo Prime LLP | | 2015 |
| Solution Rail Limited | Construction | 2006 |
| Solutions Edge Ltd | Information & communication | 2011 |