| Equity Nest Ltd | Real estate | 2025 |
| ER Highway Services Limited | Construction | 2026 |
| Escape @ Sanmarie Beauty Spa Ltd | Other services | 2023 |
| ESH Car Sales & Rentals Limited | Wholesale & retail | 2020 |
| Esprinting Ltd | Manufacturing | 2007 |
| Essential Crafts Ltd | Wholesale & retail | 2014 |
| Estates Roofing Ltd | Professional & scientific | 2017 |
| Euro BAH Three Limited | Information & communication | 2010 |
| European Clean Energy Fund, L.P. | | 2006 |
| Everest Estates & Developments Ltd | Real estate | 2026 |
| Everest Logistics Limited | Transport & logistics | 2024 |
| Evolve Heating Services Ltd | Construction | 2021 |
| Evotranspire Ltd | Information & communication | 2023 |
| EW Talent Limited | Administrative & support | 2024 |
| EWM (Northern) Holdings Limited | Professional & scientific | 2020 |
| Excalibur Fabrications Limited | Manufacturing | 2008 |
| Excel Construction (Newcastle) Limited | Construction | 1998 |
| Exel Property Developments Limited | Construction | 2004 |
| Express Direct Supplies Ltd | Wholesale & retail | 2024 |
| Express Gates Limited | Manufacturing | 2010 |
| Extensive Engineering Solutions Limited | Construction | 2021 |
| EY Karate Ltd | Arts & recreation | 2024 |
| Fabit Limited | Manufacturing | 2025 |
| Factory Cat (UK) Limited | Information & communication | 2010 |
| Fagan-Grange Roofing Limited | Construction | 2026 |
| Fairgrieve Composites Limited | Manufacturing | 2010 |
| Fairview Windows North East Ltd | Other services | 2009 |
| Fairway Commercial Finance Limited | Financial services | 2024 |
| Fairway Mortgage Advice Limited | Financial services | 2024 |
| Falcon Kitchens and Bedrooms Limited | Construction | 2004 |
| Family Focus North East CIC | Education | 2025 |
| Fammily Group Ltd | Information & communication | 2018 |
| Farefence NW Limited | Construction | 2011 |
| Fastglass (North East) Limited | Manufacturing | 2012 |
| Fastglass Replace Limited | Wholesale & retail | 2021 |
| Fault Finder MOT Ltd | Wholesale & retail | 2025 |
| FBH Investment LLC | | 2024 |
| FCB Consultancy Limited | Information & communication | 2019 |
| FEG Global Ltd | Professional & scientific | 2021 |
| FEG Ltd | Professional & scientific | 2004 |
| Fenham Stores Ltd | Wholesale & retail | 2004 |
| Fenwick Specialist Cleaning Services Limited | Administrative & support | 2011 |
| Ferndale Residential Lettings Ltd | Real estate | 2026 |
| Ferschl Ltd | Manufacturing | 2024 |
| FIA Technology Services, LLC | | 2025 |
| Fidget Digits Limited | Manufacturing | 2022 |
| Fifteen Twelve Humes Ltd | Professional & scientific | 2023 |
| Fifty Eight Sivas Ltd | Hospitality | 2023 |
| Finca Microfinance Global Services, LLC | | 2018 |
| Fingey Ltd | Wholesale & retail | 2024 |
| First ARC Welding Consulting Ltd | Professional & scientific | 2017 |
| First Call Medicals Limited | Health & social care | 2024 |
| First Call Properties NE Ltd | Real estate | 2020 |
| First Choice Cosmetics Ltd | Wholesale & retail | 2023 |
| First Finance Group Ltd | Financial services | 2021 |
| FIRST4PLAYGROUNDS Limited | Education | 2013 |
| Fitness Undiluted Ltd | Arts & recreation | 2024 |
| Flashh Ltd | Transport & logistics | 2024 |
| Fletcher Gamble Holdings Ltd | Financial services | 2021 |
| Flooring Trade Counter Limited | Wholesale & retail | 2024 |
| Food&Drive Ltd | Transport & logistics | 2025 |
| Forklifts and Access Ltd | Manufacturing | 2018 |
| Forme Capital Group Limited | Financial services | 2026 |
| Formosa Property Management Ltd. | Real estate | 2013 |
| Forrest Consultants Limited | Other services | 2021 |
| Fourdam Limited | Manufacturing | 2020 |
| Foxcot Ltd | Transport & logistics | 2025 |
| Fraction.Ai Ltd | Information & communication | 2025 |
| Frameworks Sustainability & Innovation Limited | Wholesale & retail | 2021 |
| Francis Transport Limited | Transport & logistics | 1998 |
| Francis Transport Property Ltd | Real estate | 2016 |
| FRESH4ALL Limited | Agriculture & fishing | 2024 |
| Frith Wall Properties (NE) Ltd | Real estate | 2022 |
| Fuelvac Limited | Administrative & support | 2009 |
| Full Spectrum Contracts Ltd | Professional & scientific | 2025 |
| Futurebox Media Ltd | Manufacturing | 2023 |
| Futurebox Studios CIC | Education | 2025 |
| G & R Contractors Limited | Construction | 2003 |
| G & S Property Investco Limited | Real estate | 2023 |
| G & SS Management Limited | Administrative & support | 2016 |
| G Leisure 4 Limited | Hospitality | 2015 |
| G Leisure 5 Limited | Hospitality | 2015 |
| G Leisure Group Limited | Real estate | 2016 |
| G Leisure Ltd | Administrative & support | 2010 |
| G Leisure Property Development Limited | Construction | 2016 |
| G S Property Management Limited | Real estate | 2002 |
| G W Exhausts Limited | Professional & scientific | 2020 |
| G&J and Sons Ltd | Hospitality | 2026 |
| G-Fit Studio & Personal Training Limited | Arts & recreation | 2018 |
| G-Tec (Electrical Contractor) Limited | Manufacturing | 2003 |
| G2 Doner & Kebab Manufacturing Company Ltd | Manufacturing | 2017 |
| Gabriel Beldean Ltd | Transport & logistics | 2025 |
| Gadcap Technical Solutions Ltd | Manufacturing | 2018 |
| Galea Brothers Homes Ltd | Real estate | 2023 |
| Galea Engineering Solutions Ltd | Manufacturing | 2026 |
| Galsingh Limited | Professional & scientific | 2024 |
| Gamco Properties Limited | Real estate | 2025 |
| Ganiray Systems Limited | Information & communication | 2025 |
| Ganley Lettings Ltd | Real estate | 2023 |
| GAV Walker Limited | Information & communication | 2019 |