| Robinson Goss Limited | Administrative & support | 2003 |
| Rocaway Ltd | Arts & recreation | 2006 |
| Rockspider Limited | Professional & scientific | 1999 |
| Roman Motors (Westavon) Limited | Wholesale & retail | 1976 |
| Roofgard Ltd | Construction | 2023 |
| ROOT2LEAN Ltd | Professional & scientific | 2005 |
| Roseta S a | | 1983 |
| ROY Yates Limited | Professional & scientific | 2006 |
| Rsca Limited | Extraterritorial | 1988 |
| Rugby Bareboards Trust | Professional & scientific | 2004 |
| Rugby Investments Ltd | Professional & scientific | 1991 |
| Rugby Property Limited | Real estate | 1999 |
| Rugby Spice and Herb Ltd | Hospitality | 2018 |
| Rugby Taverns Limited | Hospitality | 1995 |
| Rugby Thornfield Indoor Bowls Club Limited | Arts & recreation | 1973 |
| Russell House Management (1994) Limited | Households | 1994 |
| Russell House Management Company Limited | Real estate | 1998 |
| S & F Hood Ltd | Construction | 2007 |
| S a Associates (Civil) Ltd | Professional & scientific | 2004 |
| S L Heating & Construction Limited | Construction | 2003 |
| S&J Building & Electrical Ltd | Construction | 2023 |
| Saint James the Great Limited | Households | 1996 |
| Salmon Harvester Properties Limited | Construction | 1994 |
| Saltisford Canal Trust Limited(The) | Arts & recreation | 1983 |
| Sandy Grange Limited | | 1984 |
| Satchwell & Stranks Ltd | Construction | 2004 |
| SBC Management Limited | Administrative & support | 1980 |
| SC Services (UK) Limited | Professional & scientific | 2000 |
| Scaff Wags Ltd | Extraterritorial | 2023 |
| Search UK Pest Control Limited | Professional & scientific | 2002 |
| SEE Change Centres Limited | Administrative & support | 1997 |
| Selling Interactions Ltd | Administrative & support | 2010 |
| SG Engineers (Midlands) Limited | Manufacturing | 2004 |
| Sh&Ks Properties Limited | Real estate | 2025 |
| Sheetmetal Techniques Limited | Manufacturing | 1964 |
| Sheldon Contracting Company Limited | | 1966 |
| Sheltale Limited | Households | 1980 |
| Shire Foods Limited | Manufacturing | 1970 |
| Sholuk Trading Ltd | Wholesale & retail | 2024 |
| Shuayb Ltd | Wholesale & retail | 2006 |
| Sibbasbridge Limited | Construction | 1966 |
| Sielchal Limited | Professional & scientific | 1999 |
| Siglead Europe Limited | Professional & scientific | 2008 |
| Sigma Consulting Services Limited | Information & communication | 1998 |
| SIGMA30 Ltd | Real estate | 2008 |
| Silkmere Limited | Professional & scientific | 1988 |
| Silo Construction Limited | Wholesale & retail | 1978 |
| Simon Gooding Production Management Ltd | Arts & recreation | 2007 |
| Simply Stitches Ltd | Other services | 2006 |
| Simsmetal UK (Midwest) Limited | Professional & scientific | 1955 |
| Sinnott Storage Limited | Administrative & support | 2022 |
| SJB Birkdale Ltd | Hospitality | 2025 |
| Sjck Limited | Administrative & support | 2005 |
| Skeet European Limited | Transport & logistics | 2015 |
| Skeldon Technologies Limited | Professional & scientific | 2024 |
| Sky Window Doctor Gwynedd Limited | Administrative & support | 2016 |
| Sky Window Doctor Powys Limited | Administrative & support | 2016 |
| Smallpeice Trust(The) | Education | 1966 |
| Smarteenies Ltd | Health & social care | 2005 |
| Smith and Yearsley | | 1987 |
| Smokerose Limited | Households | 1979 |
| Smoothcoat UK Limited | Construction | 2010 |
| Sober for Good Ltd | Professional & scientific | 2025 |
| Socialmove Limited | Households | 1986 |
| Solutions Services Ltd | Administrative & support | 2004 |
| Solutions Squared Limited | Information & communication | 1999 |
| Soni Enterprises (Nuneaton) Limited | | 1984 |
| Southam Carpets Limited | Wholesale & retail | 2005 |
| Southern Bearings Limited | Wholesale & retail | 1980 |
| Special EFX Holdings Limited | Manufacturing | 2022 |
| Special EFX Limited | Manufacturing | 2004 |
| Spectre (UK) Limited | Administrative & support | 2002 |
| Spiritplace Limited | Hospitality | 1991 |
| Splitrock Commercial Ltd | Manufacturing | 2025 |
| Springdale Construction Limited | Construction | 2003 |
| Sprite Limited | Manufacturing | 1994 |
| Square DOT Limited | Professional & scientific | 2000 |
| ST Programme Management Limited | Professional & scientific | 2006 |
| Staggs Limited | Wholesale & retail | 1997 |
| Stainwright Limited | Professional & scientific | 1971 |
| Steelhead Developments LLP | | 2005 |
| Stepnell Limited | Construction | 1946 |
| Steve Crowe & SON Limited | Manufacturing | 2001 |
| Steve Duffy Limited | Construction | 2004 |
| Steve Gaunt Limited | Professional & scientific | 2005 |
| Steve Woodhead Limited | Information & communication | 2003 |
| Steven R Taylor Consultancy Limited | Construction | 2004 |
| Stonebridge Vehicles Limited | Wholesale & retail | 2012 |
| Stowe & Co (Builders) Limited | Construction | 1952 |
| Stratford-Upon-Avon Town Trust | Administrative & support | 2001 |
| Streetstylez Limited | Administrative & support | 2007 |
| Stretch Management Limited | Professional & scientific | 2007 |
| Studley Self Storage Limited | Extraterritorial | 1975 |
| Subcon Laser Cutting Ltd. | Manufacturing | 1988 |
| Suckcess Tanker Services Limited | Administrative & support | 2004 |
| SUE Pike Equine & Animal Rescue | Professional & scientific | 1995 |
| Sun Leisure (2001) Limited | Other services | 2001 |
| Sunshine EOT Limited | Financial services | 2024 |
| Sutton Coldfield Squash Rackets Club Limited | Arts & recreation | 1963 |
| Suzie's Alpacas Ltd | Other services | 2017 |