| Salt Creative Movement Ltd | Professional & scientific | 2024 |
| Salvia Limited | Professional & scientific | 2018 |
| SAM Orton Carpentry Services Limited | Construction | 2020 |
| SAMJ3 Limited | Real estate | 2021 |
| Samra Legal Limited | Professional & scientific | 2022 |
| Sams Asset Management Ltd | Real estate | 2026 |
| Samurai Academy Limited | Education | 2025 |
| Samurai Alliance CIC | Education | 2025 |
| Samurai Vehicle Technologies Ltd | Professional & scientific | 2024 |
| Sandalwest Limited | Transport & logistics | 1990 |
| Sandhr Consultancy & Coaching Ltd | Professional & scientific | 2023 |
| Sandnes Norsk Property Management Ltd | Households | 2020 |
| Sandpiper Estates Limited | Real estate | 1995 |
| Sandpiper TKL (Manor Farm) Limited | Construction | 2022 |
| Sandpiper TKL Investments Limited | Real estate | 2020 |
| Sandpiper TKL Limited | Construction | 2015 |
| Sandton Grenville Limited | Real estate | 2012 |
| Sanlab Robotics Limited | Manufacturing | 2024 |
| Sansom & Company Accountants Limited | Professional & scientific | 2018 |
| Sarah Developments Ltd | Real estate | 2025 |
| Sarah Mcmillan Limited | Hospitality | 2021 |
| Saskia Niderost Limited | Education | 2019 |
| Saturday Collectors Auctions Limited | Wholesale & retail | 1981 |
| Sautereau and Stratford Limited | Administrative & support | 2018 |
| Savanna Consultants Limited | Professional & scientific | 2016 |
| Save OUR Shipston Ltd | Other services | 2026 |
| SAW the GAP Consultancy Limited | Education | 2011 |
| SBC Cheltenham Management Limited | Administrative & support | 2016 |
| SBC Gloucester Management Limited | Administrative & support | 2016 |
| Scandinavia Trading Company UK Limited | Wholesale & retail | 2024 |
| Scanoil Limited | Administrative & support | 1980 |
| SCC Engineering Ltd | Professional & scientific | 2024 |
| Scenexus Ltd | Information & communication | 2026 |
| SCG Cybersecurity Consulting Limited | Information & communication | 2025 |
| Schneider Mirrors Limited | Manufacturing | 2023 |
| Schofield Marketing Limited | Extraterritorial | 2017 |
| Scholastic Book Clubs Limited | Information & communication | 1979 |
| Scholastic Limited | Information & communication | 1961 |
| Scholastic UK Ltd | Information & communication | 2002 |
| School Bell Mews Management Company Limited | Households | 1987 |
| Scott Bradbury Limited | Information & communication | 2003 |
| Scott Moreton Ltd | Construction | 2012 |
| Scott Smith Football Coaching Ltd | Education | 2026 |
| Scott's Bricklaying Contractors (Midlands) Limited | Construction | 2017 |
| Scrive Ltd | Administrative & support | 2021 |
| SE Mechanica Ltd | Professional & scientific | 2025 |
| Seabell AAA Ltd | Wholesale & retail | 2025 |
| Sean Bull Design Limited | Professional & scientific | 2020 |
| SEC Accessories UK Ltd | Manufacturing | 2025 |
| Second Farnells Limited | Real estate | 2024 |
| Secret Properties Limited | Real estate | 2013 |
| SECTOR1AUTOMOTIVE Limited | Wholesale & retail | 2025 |
| Sedlescombe House RTM Company Ltd | Households | 2025 |
| SEF Consultants Limited | Professional & scientific | 2010 |
| Select Rims Limited | Wholesale & retail | 2011 |
| Selitar Limited | Wholesale & retail | 1990 |
| Sellers of Leeds Limited | Professional & scientific | 1971 |
| Send Supported LLP | | 2017 |
| Sensio Care Ltd | Information & communication | 2023 |
| Sensonic Design Limited | Administrative & support | 2021 |
| Sequence Driver Training Ltd | Education | 2026 |
| Serani Hotels Ltd | Financial services | 2017 |
| Sercon Construction Services Ltd | Construction | 2021 |
| Servicing in a Nutshell Ltd | Other services | 2024 |
| SES Civils Limited | Construction | 2017 |
| Sethi Ventures Limited | Real estate | 2023 |
| Seven Arches (Barford) Management Company Limited | Households | 2017 |
| Seven Longton Grove WSM Management Company Ltd | Households | 2022 |
| Seventh Heaven Services Ltd | Hospitality | 2024 |
| SEW Demicious Ltd | Wholesale & retail | 2025 |
| Seymour (Alcester) Management Company Limited | Administrative & support | 1982 |
| SFD Investments Limited | Financial services | 2024 |
| SFW4 Ltd | Households | 2019 |
| SG International Holdings Limited | Financial services | 2015 |
| SGK Dynamics Limited | Professional & scientific | 2023 |
| Sgorbini Psychotherapy Ltd | Health & social care | 2023 |
| Shackleton Maintenance Ltd | Construction | 2024 |
| Shakes Panda Limited | Hospitality | 2021 |
| Shakespeare Farms Limited | Agriculture & fishing | 1961 |
| Shaniera Ltd | Wholesale & retail | 2025 |
| Shanklin Developments Limited | Construction | 2014 |
| Shape Your Bits Computer Services Ltd | Information & communication | 2010 |
| Shark Enterprises Ltd | Professional & scientific | 2019 |
| SHC Advisory Ltd | Professional & scientific | 2024 |
| Shelby L Limited | Construction | 2019 |
| Shemightbe Limited | Arts & recreation | 2018 |
| Shepherd Smail Ltd | Professional & scientific | 2012 |
| Sherbourne House Management Limited | Households | 2002 |
| Sherbourne Park Events Limited | Other services | 2019 |
| Shere Enterprises Ltd | Information & communication | 2024 |
| Shield Investments Limited | | 2002 |
| Shift Happens Therapy Limited | Health & social care | 2024 |
| Shire Developments Ltd | Real estate | 2017 |
| Shire Mortgage Solutions Ltd | Financial services | 2023 |
| Shire Scaffolding Midlands Limited | Construction | 2014 |
| Shire Shrinkwrap Ltd | Construction | 2021 |
| Shire Signage Company Ltd | Manufacturing | 2025 |
| Shires Gold Limited | Wholesale & retail | 2019 |
| Shirestone Property Ltd | Construction | 2025 |
| Shirui Lily Ltd | Administrative & support | 2020 |