| Decorationbydesign Limited | Construction | 2026 |
| Deep Understanding Limited | Information & communication | 2025 |
| Deerbarn Livery Ltd | Agriculture & fishing | 2025 |
| Deerhurst Court Limited | Households | 1993 |
| Defence College Ltd | Education | 2018 |
| Delaney Brothers Ltd | Real estate | 2022 |
| Delaney Property Group Ltd | Real estate | 2023 |
| Delgarth 2011 Limited | Financial services | 2011 |
| Delgarth Limited | Wholesale & retail | 1980 |
| Deli Project Ltd | Wholesale & retail | 2024 |
| Delightful Days Limited | Health & social care | 2019 |
| Delivers.Ai Ltd | Information & communication | 2021 |
| Delorentz & Partners UK Ltd | Information & communication | 2024 |
| Demarris Limited | Other services | 2018 |
| Denada Apex Solutions Limited | Professional & scientific | 2026 |
| Denada Design Solutions Ltd | Professional & scientific | 2006 |
| Dene River Limited | Wholesale & retail | 2018 |
| Dennis Eagle Limited | Manufacturing | 1999 |
| Densfield Limited | Professional & scientific | 2013 |
| Deol Leisure Holdings Ltd | Arts & recreation | 2026 |
| Deol Leisure Ltd | Arts & recreation | 2025 |
| Design Driven Innovation Limited | Professional & scientific | 2023 |
| DESIGN189 Ltd | Manufacturing | 2018 |
| Designiversity.Org Limited | Information & communication | 2016 |
| Destiny Inn Ltd | Hospitality | 2024 |
| Develco Limited | Construction | 2019 |
| Dever Saddlery Limited | Administrative & support | 2001 |
| Devlaces Ltd | Wholesale & retail | 2020 |
| Devmira Ltd | Information & communication | 2018 |
| Dextek Limited | Information & communication | 1995 |
| Dexworth Holdings Ltd | Construction | 2026 |
| Dezinebuild Limited | Real estate | 2015 |
| DG Anti-Fraud Consultants Limited | Administrative & support | 2005 |
| DGD Energy Consultancy Ltd | Professional & scientific | 2017 |
| DGM Engineering & Consulting Limited | Professional & scientific | 2013 |
| Dhaka Ahsania Mission | Education | 1995 |
| Dhesi Property Group Limited | Administrative & support | 2023 |
| Dhillon Capital First Ltd | Real estate | 2026 |
| Dhinjan Holdings Group Ltd | Financial services | 2025 |
| DHM Logistics Limited | Transport & logistics | 2019 |
| Diana M Event Management Ltd | Administrative & support | 2025 |
| Diane Webb (Therapies & Coaching) Ltd | Professional & scientific | 2017 |
| Dibro Limited | Manufacturing | 2013 |
| Dicks Motor Garage Ltd | Wholesale & retail | 2022 |
| Digi Design Co Architecture Ltd | Professional & scientific | 2011 |
| Digital Art Studio Limited | Manufacturing | 2015 |
| Digital Language Partners Ltd | Information & communication | 2023 |
| Digital Riot Limited | Information & communication | 2017 |
| Digital Workforce Services Ltd | Information & communication | 2019 |
| Digitwin Technology Ltd | Professional & scientific | 2021 |
| Dinaji Ltd | Wholesale & retail | 2020 |
| Disab UK Limited | Wholesale & retail | 1984 |
| Disrupt Talent Holdings Limited | Financial services | 2026 |
| Disrupt Talent Limited | Administrative & support | 2022 |
| Disrupt Talent Staffing Limited | Administrative & support | 2026 |
| Distantpxl Ltd | Information & communication | 2019 |
| Diva Rental Limited | Real estate | 2017 |
| Divine Luxury Home Rentals Limited | Real estate | 2026 |
| DJ Pickering Consultants Limited | Professional & scientific | 2003 |
| DJ Yoda Limited | Arts & recreation | 2010 |
| Djnb Limited | Hospitality | 2024 |
| Dknb Limited | Hospitality | 2024 |
| DM Courier&Logistics Ltd | Transport & logistics | 2017 |
| Dmalik Consultancy Ltd | Information & communication | 2025 |
| DMC UK Production Limited | Information & communication | 2025 |
| DMG Build Ltd | Construction | 2016 |
| DMS Marine Services Limited | Manufacturing | 2011 |
| DMU Investments Limited | Professional & scientific | 2025 |
| DNA Paving & Construction Ltd | Extraterritorial | 2018 |
| DNX Limited | Information & communication | 2025 |
| Docky Systems Limited | Professional & scientific | 2024 |
| Doctrin Limited | Information & communication | 2020 |
| Docuex Limited | Information & communication | 2016 |
| Dog Deli Ltd | Wholesale & retail | 2022 |
| Dog Owners Club Limited | Wholesale & retail | 2023 |
| Dogfather Training Ltd | Other services | 2012 |
| Domestic Cooling Solutions Ltd | Construction | 2023 |
| Domino Contracting Ltd | Information & communication | 2009 |
| Dormy Golf UK Ltd | Wholesale & retail | 2023 |
| Down a Well Ltd | Arts & recreation | 2026 |
| Dragon Retail 507 Limited | Wholesale & retail | 2025 |
| Dragon Retail 519 Limited | Wholesale & retail | 2025 |
| Dragon Retail 520 Limited | Wholesale & retail | 2025 |
| Dragon Retail 532 Limited | Wholesale & retail | 2025 |
| Drake Howard Property Limited | Real estate | 2013 |
| Dream Big (Worldwide) Limited | Professional & scientific | 2014 |
| Dream Naturals Ltd | Extraterritorial | 2021 |
| DREAMFORM64 Limited | Professional & scientific | 2024 |
| Dreamsolve Ltd | Manufacturing | 2023 |
| Drew House Ltd | Households | 2024 |
| Drewin Limited | Construction | 2015 |
| Drivalytix Limited | Information & communication | 2017 |
| Driveaway Motoring Services Ltd | Financial services | 2015 |
| Dropr Limited | Wholesale & retail | 2022 |
| DRW Creative Limited | Professional & scientific | 2023 |
| Dryhurst Marketing Limited | Professional & scientific | 2020 |
| DS Electrical Midlands Ltd | Construction | 2020 |
| DS Group Service Limited | Administrative & support | 2023 |
| DT Pharmacies Holdings Limited | Professional & scientific | 2008 |
| DT Properties Holdings Limited | Professional & scientific | 2008 |