| Sazom Ltd | Hospitality | 2023 |
| SB Colour Limited | Other services | 2023 |
| SB Consultants Ltd | Administrative & support | 2023 |
| SB Engineering & Aviation Solutions Limited | Professional & scientific | 2018 |
| SB ENT Limited | Health & social care | 2024 |
| SB HV Civil Solutions Limited | Construction | 2024 |
| SB Marine Limited | Manufacturing | 2021 |
| SB Northern Ltd | Administrative & support | 2025 |
| SBC Commercials Ltd | Wholesale & retail | 2019 |
| SBD Accounting Services Limited | Professional & scientific | 2003 |
| SBK Estate NW Limited | Real estate | 2019 |
| SBK Medical Limited | Health & social care | 2015 |
| SBR Engineering Limited | Administrative & support | 2014 |
| SBT Property Limited | Real estate | 2021 |
| SBW Surveying Services Ltd | Professional & scientific | 2017 |
| SC Funding Limited | Information & communication | 2025 |
| SC IT Consulting Limited | Information & communication | 2017 |
| SC Measurement & Instrumentation Limited | Administrative & support | 2014 |
| SC Metering Services Ltd | Administrative & support | 2025 |
| SC One Limited | Construction | 2021 |
| SC Security Trustee Limited | Administrative & support | 2025 |
| Scaffholder Supplies Limited | Wholesale & retail | 2011 |
| Scan Assure Medical Ultrasound Limited | Health & social care | 2008 |
| Scandfiafelt PDC AB. | | 1991 |
| Scandiscript Ltd | Administrative & support | 2023 |
| Scanlon Engineering Ltd | Administrative & support | 2025 |
| Scarlet Triangles Limited | Financial services | 2018 |
| Scarlett & Fern Limited | Administrative & support | 2007 |
| SCC Autos Ltd | Manufacturing | 2026 |
| SCC HR Consulting Ltd. | Administrative & support | 2014 |
| Scgk Developments Limited | Real estate | 2023 |
| Schitgopkar Ltd. | Health & social care | 2018 |
| Schmoot IT Limited | Administrative & support | 2016 |
| Schofield Enterprises Corporation Ltd | Financial services | 2022 |
| Scholars Property Limited | Real estate | 2016 |
| Scholefield Construction Limited | Manufacturing | 2025 |
| School Lane Plan Checking Ltd | Construction | 2022 |
| School View Flats Ltd | Households | 2021 |
| Schooling IT Consulting Limited | Information & communication | 2020 |
| Schotech Engineering Group Ltd | Professional & scientific | 2023 |
| Schumiuk Limited | Professional & scientific | 2014 |
| Schwaben Consulting UK Limited | Administrative & support | 2014 |
| Science Based Leadership Limited | Professional & scientific | 2008 |
| Science Industry Assessment Service Limited | Public administration | 2015 |
| Science Solutions Recruitment Limited | Administrative & support | 2014 |
| Science Tree Ltd | Professional & scientific | 2026 |
| Science-Supplies Limited | Wholesale & retail | 2022 |
| Scientific Collection Re-Cycling and Processing Limited | Construction | 1976 |
| Scirocco Group Limited | Professional & scientific | 2021 |
| SCK Consultancy Ltd | Administrative & support | 2022 |
| SCK Consulting Limited | Other services | 2014 |
| Scoot Car Hire Limited | Administrative & support | 2022 |
| Scoot in the Boot Ltd | Wholesale & retail | 2024 |
| Scopeguard Limited | Manufacturing | 2007 |
| Score Creative Ltd | Education | 2007 |
| Scorpius Projects Ltd | Administrative & support | 2021 |
| Scot Project Services Limited | Professional & scientific | 2018 |
| Scot Williams Ltd | Arts & recreation | 2021 |
| Scott Aitken Limited | Administrative & support | 2008 |
| Scott Electrical Services Limited | Administrative & support | 2017 |
| Scott QS Services Ltd | Administrative & support | 2024 |
| Scott Software Products Limited | Information & communication | 2000 |
| Scottorthopaedics Limited | Health & social care | 2026 |
| Scottsdale Golf (U.K.) Limited | Wholesale & retail | 1981 |
| Scottson Plumbing and Heating Limited | Construction | 2018 |
| Scouseafrican 1203 Ltd | Hospitality | 2025 |
| Scout Investments Ltd | Financial services | 2019 |
| Scratch Repair Company Ltd | Administrative & support | 2011 |
| Scrc Limited | Professional & scientific | 2003 |
| Scriberpharm Ltd | Health & social care | 2014 |
| Scrubzz Ltd | Administrative & support | 2024 |
| Scrum to Saddle Racing Ltd | Arts & recreation | 2025 |
| SCS Manager Ltd | Construction | 2026 |
| Scsl Engineering Ltd | Professional & scientific | 2019 |
| SCT Hospitality Consulting Ltd | Professional & scientific | 2026 |
| Sculpt and Design Ltd | Administrative & support | 2025 |
| Scuti Ltd | Administrative & support | 2025 |
| Scythia Partners Limited | Administrative & support | 2012 |
| Scōp Supplement Ltd | Manufacturing | 2026 |
| SD Aesthetics Ltd | Health & social care | 2014 |
| SD and ER Properties Limited | Households | 2020 |
| SD CPM Ltd | Administrative & support | 2016 |
| SD Egerton Limited | Construction | 2017 |
| SD Mechanical Services Limited | Administrative & support | 2025 |
| SD Technical Limited | Administrative & support | 2008 |
| SD Technology Limited | Professional & scientific | 2016 |
| SDC Construction Services Limited | Administrative & support | 2015 |
| SDC Engineering Limited | Administrative & support | 2012 |
| SDC Saas Solutions Limited | Administrative & support | 2025 |
| SDF Controls Ltd | Administrative & support | 2023 |
| SDG Electrical Limited | Other services | 2018 |
| SDG9 Limited | Construction | 2023 |
| SDK International Limited | Financial services | 2015 |
| SDM Design Solutions Limited | Administrative & support | 2009 |
| SDM Security Limited | Professional & scientific | 2016 |
| SDM Site Contracts Ltd | Professional & scientific | 2019 |
| SDM Technical Services Limited | Administrative & support | 2015 |
| SDN Properties Limited | Real estate | 2015 |
| SDR Woodflooring Limited | Wholesale & retail | 2026 |
| SDS Ventures Ltd | Financial services | 2021 |