| Scent Home Fragrances Limited | Wholesale & retail | 2019 |
| Schengenvizedanismani Ltd | Professional & scientific | 2024 |
| Schipor Tutoring Limited | Education | 2025 |
| Schleider Limited | Information & communication | 2026 |
| Scope Global Exchange Ltd | Other services | 2025 |
| Scorelogiclab Ltd | Information & communication | 2026 |
| Scott Duffy Plastering Limited | Construction | 2008 |
| SDC Future Ltd | Real estate | 2024 |
| SDC Online Limited | Wholesale & retail | 2015 |
| Sdfu Limited | Other services | 2017 |
| SDR Construction Limited | Construction | 2023 |
| SDR Utilities Ltd | Construction | 2020 |
| Seal Packaging Limited | Wholesale & retail | 1990 |
| Sean Nash Limited | Administrative & support | 2008 |
| Search Techniques Limited | Manufacturing | 2002 |
| Second Coming the Movie Ltd | Arts & recreation | 2019 |
| Security Response Services GB Ltd | Administrative & support | 2018 |
| Seda Beauty Limited | Other services | 2019 |
| Sekusile Limited | Health & social care | 2016 |
| Selc Architecture Ltd | Professional & scientific | 2019 |
| Select Poultry & Meat Ltd | Wholesale & retail | 2003 |
| Select Tiles and Bathrooms Ltd | Wholesale & retail | 2026 |
| Selever Build Ltd | Construction | 2019 |
| Selin Windows Ltd | Manufacturing | 2024 |
| Semani Limited | Hospitality | 2016 |
| SEN Property SPV Limited | Financial services | 2025 |
| Send Connect Ltd | Information & communication | 2024 |
| Senior Stylist Ltd | Other services | 2025 |
| Senseit Recruitment Ltd | Administrative & support | 2022 |
| SEP Capital Limited | Financial services | 2021 |
| Sepshad Ltd | Real estate | 2025 |
| Serenai Ltd | Information & communication | 2026 |
| Serenelets Ltd | Hospitality | 2024 |
| Serenity 55 Ltd | Real estate | 2019 |
| Serevani Ltd | Professional & scientific | 2018 |
| Serverfarm Global DC Ltd | Information & communication | 2016 |
| Serverfarm Global Holdings Ltd | Financial services | 2016 |
| Serverfarm Holding UK Ltd | Information & communication | 2019 |
| Services Work & Trips Ltd | Professional & scientific | 2022 |
| Sesa Limited | Real estate | 2025 |
| SET Creations Ltd | Manufacturing | 2010 |
| SET Pace Security Training Ltd | Administrative & support | 2025 |
| SEV Building Contractors Ltd | Construction | 2007 |
| Seval Properties Limited | Real estate | 1997 |
| Seven Dials Apparel Ltd | Wholesale & retail | 2013 |
| Several Kettles Limited | Wholesale & retail | 2024 |
| Sexfulness Ltd | Wholesale & retail | 2020 |
| Seyhan Huseyin Property Ltd | Real estate | 2025 |
| SF LHR Ltd | Real estate | 2017 |
| Sffo Ltd | Professional & scientific | 2019 |
| SFR Estates Ltd | Real estate | 2019 |
| SG Devops Consultancy Limited | Information & communication | 2015 |
| SG Group Chauffeurs Ltd | Transport & logistics | 2023 |
| SG UK Constructions Ltd | Construction | 2023 |
| SG UK Services Ltd | Construction | 2024 |
| SG9 Consulting Limited | Information & communication | 2024 |
| SGA Corporation Limited | Wholesale & retail | 2011 |
| Sga&W Ltd | Transport & logistics | 2019 |
| SGM Trans Ltd | Transport & logistics | 2024 |
| Shaanvin Ltd | Real estate | 2025 |
| Shahanshah Tandoori Ltd | Hospitality | 2020 |
| Shalom Enterprises Ltd | Administrative & support | 1999 |
| Shanti Bell Limited | Professional & scientific | 2019 |
| Shantikunj Limited | Financial services | 2006 |
| Shaolin Wellbeing Limited | Health & social care | 2012 |
| Sharkey Homes Ltd | Real estate | 2025 |
| SHD Software Ltd | Information & communication | 2024 |
| SHE Believed SHE Could, SO SHE DID Ltd | Professional & scientific | 2018 |
| Sheail Limited | Professional & scientific | 2024 |
| Shen Property Ltd | Real estate | 2023 |
| Shephards Hill Limited | Other services | 2019 |
| Shepherds Lettings Ltd | Real estate | 2021 |
| Shevill Ltd | Wholesale & retail | 2024 |
| Shire Lofts Limited | Construction | 2022 |
| Shirlbern Properties Limited | Real estate | 2004 |
| Shish SK Ltd | Hospitality | 2025 |
| SHIV9 Optics Ltd | Professional & scientific | 2025 |
| Shivaay-Transformation Company Ltd | Information & communication | 2023 |
| Shivnen Holdings Limited | Professional & scientific | 2016 |
| Shivnen Properties Ltd | Real estate | 2023 |
| Shoal Seafood Ltd | Wholesale & retail | 2017 |
| Shooting Stars Gym Ltd | Education | 2022 |
| Shop 2 Save Ltd | Wholesale & retail | 2026 |
| Shrewness Property Group Limited | Real estate | 2025 |
| Shuban Investment Limited | Real estate | 2021 |
| Shubh Builders Ltd | Construction | 2025 |
| Shudoc Limited | Wholesale & retail | 2017 |
| Si-Si Transport Ltd | Transport & logistics | 2018 |
| SIA & Sons Ltd | Professional & scientific | 2024 |
| Siba Trade UK Ltd | Wholesale & retail | 2021 |
| Sibell Organization Ltd | Hospitality | 2025 |
| Siblinz Trading Group Ltd | Real estate | 2024 |
| Sicilia Roots Limited | Hospitality | 2015 |
| Sicilian&Co Ltd | Hospitality | 2016 |
| Siddiquee Ltd | Wholesale & retail | 2025 |
| Siddiquee Properties Ltd | Real estate | 2026 |
| Sieleonish Limited | Health & social care | 2022 |
| Sienna Autumn Investments Ltd | Real estate | 2025 |
| Sienna Communications Limited | Wholesale & retail | 2009 |
| Sierra and Leone Limited | Health & social care | 2021 |