| SAM Kane Limited | Information & communication | 1990 |
| Sam's Strings Ltd | Wholesale & retail | 2020 |
| Samina Haider Limited | Information & communication | 2017 |
| Sams Motors Grays Limited | Manufacturing | 2022 |
| Samsen Limited | Professional & scientific | 2003 |
| Sanctuary Farm Upshire Limited | Agriculture & fishing | 2020 |
| Sandell's Yard Management Company Limited | Households | 2024 |
| Sandra Karen Allen Limited | Extraterritorial | 2023 |
| Sanzhaev Trading Limited | Wholesale & retail | 2025 |
| Saronic Consultancy Ltd | Professional & scientific | 2019 |
| Sashwood Limited | Real estate | 2020 |
| Satriale Holdings Limited | Real estate | 2015 |
| Satriale Limited | Real estate | 2015 |
| Saverline LLC Ltd | Wholesale & retail | 2023 |
| Sbeach Services Limited | Construction | 2021 |
| Scaffolding Inc Limited | Construction | 2014 |
| Sclpt Ltd | Arts & recreation | 2025 |
| Scoop and Scoop Ltd | Wholesale & retail | 2021 |
| Scotsdale Hill LLP | | 2017 |
| Scott Burns Limited | Construction | 2004 |
| Scribble Creative Company Ltd | Professional & scientific | 2025 |
| Scrip Publishing Limited | Administrative & support | 1980 |
| SD Autos and Repairs Ltd | Wholesale & retail | 2025 |
| SDE Logistic Ltd | Transport & logistics | 2018 |
| Sea Change Land & Property Limited | Real estate | 2021 |
| Sea Wave Energy Limited | Professional & scientific | 2011 |
| Seantuition Ltd | Education | 2024 |
| Seaways Limited | Hospitality | 2026 |
| Sectur Property Management Ltd | Construction | 2026 |
| Securiasent Ltd | Information & communication | 2024 |
| Security Advanced Shutters UK Ltd | Manufacturing | 2023 |
| SEE Y Limited | Wholesale & retail | 2025 |
| SEL Market Limited | Wholesale & retail | 2026 |
| Selkirk Data Systems Limited | Information & communication | 2016 |
| Selleck Biotechnology Limited | Wholesale & retail | 2023 |
| SEM Upwork Pro SE Ltd | Professional & scientific | 2022 |
| Senu Traders Ltd | Transport & logistics | 2010 |
| Serhat Ahmet Limited | Wholesale & retail | 2014 |
| Sermin Nevzat Children in Need Limited | Other services | 2025 |
| Sertran Limited | Information & communication | 2014 |
| Sevva Investments Limited | Real estate | 2015 |
| Sevva Ltd | Wholesale & retail | 2011 |
| SEW Amazing Limited | Manufacturing | 1960 |
| Seydo Baba Holding Limited | Real estate | 2026 |
| SG Digital Media Solutions Ltd | Professional & scientific | 2019 |
| SG Grooming Ltd | Other services | 2025 |
| SG Mortgage Services Limited | Financial services | 2022 |
| Shah Hussain Group Limited | Wholesale & retail | 2024 |
| Shah Hussain Investments Ltd | Real estate | 2026 |
| Shahid Medics Limited | Health & social care | 2013 |
| Shahid Property Services Limited | Real estate | 2025 |
| Shajaie Enterprise Limited | Extraterritorial | 2012 |
| Shakir Medicare Limited | Public administration | 2024 |
| Shalesmere Limited | Real estate | 2023 |
| Share IT Limited | Information & communication | 2008 |
| Sharmead Builders Limited | | 1986 |
| Sharpedge Copier Service Ltd | Other services | 2013 |
| Shasha Movies Ltd | Information & communication | 2020 |
| Sheepcotes Lane Ltd | Real estate | 2025 |
| Shermanlabs Ltd | Administrative & support | 2020 |
| Shield Autos Ltd | Wholesale & retail | 2025 |
| Shifter Ride Ltd | Transport & logistics | 2025 |
| Shining Solutions Limited | Information & communication | 2010 |
| Shiraz South Ltd | Hospitality | 2019 |
| Shop by Anna Limited | Wholesale & retail | 2022 |
| Shorestone Holdings Ltd | Financial services | 2025 |
| Showcase Solutions Ltd | Administrative & support | 2024 |
| Showffeur Concierge Ltd | Transport & logistics | 2023 |
| Shure Europe Holdings Limited | Financial services | 2010 |
| Shure UK Limited | Wholesale & retail | 2003 |
| Sign Expert Ltd | Manufacturing | 2021 |
| Silverstone Mining and Materials Ltd | Mining & quarrying | 2026 |
| Silverthorne International Limited | Construction | 2001 |
| Simi Unisex Hair Lounge Ltd | Other services | 2025 |
| Simon Yates Limited | Professional & scientific | 2004 |
| Simos Fried Chicken Ltd | Hospitality | 2019 |
| Simple Times Limited | Real estate | 2015 |
| Simsek Real Estate and Investment Ltd | Real estate | 2025 |
| Sina Consulting Limited | Professional & scientific | 2015 |
| Sina Woodwork Ltd | Construction | 2019 |
| Site-X Security Ltd | Administrative & support | 2023 |
| Siyez Mezopotamya Ltd | Agriculture & fishing | 2021 |
| SJ Rescue & Recovery Ltd | Transport & logistics | 2021 |
| Skips 365 Limited | Water & waste | 2015 |
| Skwd Anatolian Limited | Hospitality | 2023 |
| Skwd Asia Limited | Hospitality | 2023 |
| Skwd London Limited | Real estate | 2021 |
| Skylight Motors Ltd | Wholesale & retail | 2025 |
| Skyline Properties 1 Limited | Real estate | 2003 |
| Slbc Rigging Ltd | Construction | 2011 |
| SLC Aviation Training Ltd | Education | 2025 |
| SM Chauffeur Services Ltd | Transport & logistics | 2019 |
| SM Scaffolding Ltd | Construction | 2020 |
| Smart Pavers Ltd. | Administrative & support | 2017 |
| Smart Tape & Joint Limited | Construction | 2020 |
| Smartwave Electrical Ltd | Construction | 2014 |
| Smith Rigging Services Ltd | Construction | 2025 |
| Smithsonhill Limited | Real estate | 2010 |
| SMK Diamond Decorating Ltd | Construction | 2019 |
| Snack Bar & Sunny's Cafe Ltd | Hospitality | 2025 |