| Supreme Intercontinental Ltd | Wholesale & retail | 2023 |
| Supreme Link Ltd | Construction | 2022 |
| Supreme Supermarket Limited | Hospitality | 2023 |
| Sure Air Tools Ltd | Wholesale & retail | 2022 |
| Sure Fit Security Limited | Administrative & support | 2021 |
| Sure Sealants Ltd | Construction | 2025 |
| Suresh Group Ltd | Construction | 2026 |
| Surespan Limited | Construction | 1989 |
| Surestay Group Ltd | Construction | 2024 |
| Surge Plus Group Limited | Construction | 2025 |
| Surrey Woodworks Limited | Wholesale & retail | 2009 |
| Surveying CS Ltd | Professional & scientific | 2024 |
| Survival of the Thrifted Ltd | Wholesale & retail | 2026 |
| Suryacare Limited | Health & social care | 2017 |
| Sustainable Packaging Supplies Ltd | Administrative & support | 2022 |
| Sutton Centre Car Park Limited | Real estate | 2021 |
| Sutton Ceramics Limited | Construction | 2016 |
| Sutton Coatings Ltd | Manufacturing | 2020 |
| Sutton Coldfield Construction Limited | Construction | 2010 |
| Sutton Coldfield Refurbishment Ltd | Construction | 2015 |
| Sutton Food and Beverages Ltd | Wholesale & retail | 2024 |
| Sutton Joinery Limited | Construction | 2012 |
| Sutton Products (Brownhills) Limited | Construction | 2020 |
| SUV Construction Limited | Construction | 2024 |
| Suv-Laki Leamington Limited | Hospitality | 2025 |
| Suv-Laki Lichfield Ltd | Hospitality | 2025 |
| SVB1ONE Ltd | Wholesale & retail | 2024 |
| SVS Rate Mark Ltd | Wholesale & retail | 2026 |
| SW Building & Services Limited | Construction | 2022 |
| SW Deals Ltd | Wholesale & retail | 2026 |
| SW Switchgear Limited | Manufacturing | 2025 |
| Swaadh Ltd | Hospitality | 2018 |
| Swabb Ltd | Transport & logistics | 2020 |
| Swadesh Foods Limited | Wholesale & retail | 2018 |
| Swag U.K Ltd | Wholesale & retail | 2026 |
| Swag Wholesale Ltd | Wholesale & retail | 2026 |
| Swale Pharma Ltd | Wholesale & retail | 2025 |
| Swan Flooring Limited | Wholesale & retail | 2008 |
| Swann's Property Ltd | Households | 2024 |
| Swanns Builders Ltd | Construction | 2018 |
| Swatkins Group Limited | Manufacturing | 1943 |
| Sweet Barkingside Limited | Hospitality | 2017 |
| Sweet Chin Media Group Limited | Professional & scientific | 2026 |
| Sweet Escape Desserts Ltd | Hospitality | 2014 |
| Sweet Hanley Limited | Hospitality | 2016 |
| Sweetmix Edibles Limited | Wholesale & retail | 2025 |
| Sweets and Treats Wholesale Limited | Wholesale & retail | 2013 |
| Swench Coaching Limited | Health & social care | 2020 |
| Swift Aluminium Systems Ltd | Manufacturing | 2015 |
| Swift Bathrooms Limited | Construction | 2015 |
| Swift Cctv Installation Service Ltd | Administrative & support | 2017 |
| Swift Furnishings Limited | Wholesale & retail | 2025 |
| Swift Home Improvements West Midlands Ltd | Construction | 2025 |
| Swift Park & FLY Ltd. | Professional & scientific | 2017 |
| Swift Services and Consultancy Ltd | Health & social care | 2022 |
| Swift Taxi Shuttle Rushall Ltd | Extraterritorial | 2023 |
| Swiftzy Ltd | Wholesale & retail | 2025 |
| Swimming Teachers' Association Limited(The) | Education | 1976 |
| Swinnertons Walsall Limited | Arts & recreation | 2007 |
| Swiss Computing Limited | Professional & scientific | 1995 |
| Switch Property Investments Ltd | Real estate | 2021 |
| SWJ Property Ltd | Real estate | 2026 |
| SWK Midlands Ltd | Real estate | 2026 |
| Syco Solutions Ltd | Information & communication | 2007 |
| Sycon Services Limited | Manufacturing | 2018 |
| Sylvester Consulting Engineering Ltd. | Construction | 2018 |
| Sylvester Mechanical Ltd | Construction | 2020 |
| Symbolic Accounts Ltd | Professional & scientific | 2026 |
| Symlec Fire & Security Limited | Extraterritorial | 2023 |
| Symlec Fire Limited | Extraterritorial | 2021 |
| Symlec Limited | Extraterritorial | 2011 |
| Synergy Biologics Limited | Manufacturing | 2010 |
| Synergy Procurement Solutions Ltd | Professional & scientific | 2010 |
| Synergy Recovery & Storage Ltd | Transport & logistics | 2023 |
| Synergy UN Ltd | Administrative & support | 2008 |
| Synertech Ltd | Wholesale & retail | 2019 |
| Syntegral Limited | Professional & scientific | 2010 |
| Synthos Digital Services Ltd | Extraterritorial | 2025 |
| Syro Ltd | Professional & scientific | 2025 |
| SYS Logistics Ltd | Wholesale & retail | 2023 |
| Sysj Ltd | Information & communication | 2023 |
| System Composition Limited | Information & communication | 1988 |
| Systems 4 Ltd | Real estate | 2020 |
| Systems Empowerment Limited | Information & communication | 2014 |
| Szalay Beauty Limited | Other services | 2025 |
| Szyk Ltd | Transport & logistics | 2022 |
| T & a Williams Property Limited | Financial services | 2020 |
| T & C Design & Display Limited | Professional & scientific | 2001 |
| T & C Inspection Limited | Administrative & support | 2002 |
| T & C Training Services Ltd | Administrative & support | 1995 |
| T & G Rentals Limited | Real estate | 2026 |
| T & M (UK) Limited | Hospitality | 2013 |
| T & M Pugs Limited | Other services | 2024 |
| T & P Trading (Midlands) Limited | Wholesale & retail | 2010 |
| T a Design & Construction Limited | Construction | 2024 |
| T BAG Foods Limited | Hospitality | 2025 |
| T C Cull Engineering Ltd | Manufacturing | 2019 |
| T Clarke & SON Building Limited | Construction | 2021 |
| T F Legal Limited | Other services | 2014 |
| T G S Properties Ltd | Real estate | 2019 |