| SP MID Ltd | Construction | 2020 |
| SP Pro Services Limited | Real estate | 2024 |
| Space Athlete Limited | Education | 2022 |
| Space Saver Auto Lifts Ltd | Manufacturing | 2025 |
| Spaceboosters Limited | Wholesale & retail | 2008 |
| Spag Wellness and Digital Ltd | Information & communication | 2026 |
| Spar Erdington Ltd | Wholesale & retail | 2020 |
| Sparkle BEE Ltd | Administrative & support | 2025 |
| Sparkling Paints Limited | Other services | 2023 |
| Sparkosol Ltd | Information & communication | 2022 |
| Sparton Properties Limited | Real estate | 2022 |
| Sparton Properties Midland Limited | Real estate | 2025 |
| SPB Stores Ltd | Wholesale & retail | 2024 |
| SPC2018 Limited | Manufacturing | 2018 |
| Spearhead Consulting Limited | Professional & scientific | 2018 |
| Spearhead Design Consultancy Ltd | Professional & scientific | 2002 |
| Special Formwork Limited | Extraterritorial | 2008 |
| Special Paint Properties Limited | Administrative & support | 2010 |
| Special Probability Ltd | Financial services | 2022 |
| Specialist Body Repairs Ltd | Manufacturing | 2020 |
| Spectacle Laboratory Limited | Manufacturing | 2014 |
| Specthread Limited | Other services | 1993 |
| Spectrum Care & Support Services Ltd | Health & social care | 2022 |
| Spectrum Care Services Ltd | Real estate | 2022 |
| Spectrum Fire Protection (UK) Limited | Manufacturing | 1994 |
| Spectrum Print and Visual Solutions Limited | Manufacturing | 1975 |
| Spectrum-Saurus Ltd | Health & social care | 2025 |
| Speed Well Drylining Limited | Construction | 2023 |
| Speedfloops Limited | Transport & logistics | 2018 |
| Speedking Racing Ltd | Professional & scientific | 2014 |
| Speedking Tools Limited | Professional & scientific | 2011 |
| Speedqueen Ltd | Professional & scientific | 2014 |
| Speedqueen Tools Limited | Professional & scientific | 2011 |
| Speedy's Auto Services Limited | Wholesale & retail | 2017 |
| Spend N Save Leic Limited | Wholesale & retail | 2022 |
| Spend N Save Limited | Wholesale & retail | 2006 |
| Spenhen Construction Works Ltd | Construction | 2026 |
| Spenhen Limited | Construction | 2019 |
| Spice HAY Restaurants Limited | Hospitality | 2023 |
| Spice Restaurant 00 Limited | Hospitality | 2025 |
| Spicewalsall Limited | Hospitality | 2024 |
| Spicey Designs Ltd | Professional & scientific | 2019 |
| Spicy Rooster Limited | Hospitality | 2025 |
| Spinpress Limited | Extraterritorial | 2010 |
| Spire Developments (West Midlands) Ltd | Construction | 2026 |
| Spire Group Limited | Real estate | 1998 |
| Spire Property Investments Limited | Financial services | 2012 |
| Spitalfields Inc Ltd | Wholesale & retail | 2021 |
| Splash Loans Ltd | Financial services | 2018 |
| Splash Records Limited | Information & communication | 1975 |
| Splashbacks Design Limited | Manufacturing | 2022 |
| Splashbacks Direct Ltd | Manufacturing | 2024 |
| SPM Maintenance Limited | Other services | 2023 |
| Spoc Safety Solutions Limited | Professional & scientific | 2025 |
| Spokus Limited | Construction | 2024 |
| Sportauto Limited | Financial services | 1994 |
| Sporting Khalsa Community Facilities Limited | Arts & recreation | 2011 |
| Sporting Khalsa Football Club Limited | Arts & recreation | 2010 |
| Sporting Khalsa Sports Club Limited | Arts & recreation | 2010 |
| Sporting Pathways C.I.C. | Education | 2011 |
| Sportscaped Ltd | Arts & recreation | 2025 |
| Sportstage Limited | Arts & recreation | 1988 |
| Spotlite Limited | Financial services | 2014 |
| Spoton Security Ltd. | Administrative & support | 2019 |
| SPR Search Limited | Administrative & support | 2024 |
| Spraymation Limited | Other services | 1999 |
| Sprigs & Sprogs Ltd | Hospitality | 2026 |
| Spring Cottage (Walsall) Ltd | Hospitality | 2022 |
| Spring Court Residents Association Limited | Households | 1976 |
| Spring Grove Cottage Limited | Construction | 2024 |
| Spring Legal Consultancy Limited | Professional & scientific | 2012 |
| Springdickson Global Concept Ltd | Wholesale & retail | 2026 |
| Sprinkled Smiles CIC | Hospitality | 2025 |
| SPS Automotive Limited | Wholesale & retail | 2018 |
| SPS Trans Ltd | Transport & logistics | 2019 |
| SPT Building Services Limited | Construction | 2002 |
| SPV Asset Management and Facilities Limited | Extraterritorial | 2010 |
| SPV Roofing & Cladding Limited | Real estate | 2005 |
| SPV Shopfitting and Building Limited | Construction | 2008 |
| SPV Special Projects Limited | Construction | 2008 |
| SPV Training Limited | Education | 2021 |
| Spyrotek Limited | Construction | 2020 |
| Square DOT Consulting Limited | Real estate | 2014 |
| Square Edge Projects Ltd | Construction | 2013 |
| Squarewood Capital Limited | Real estate | 2025 |
| Squeaky Cleaning Services Limited | Administrative & support | 2017 |
| Squires Garage and Road Transport Limited | Transport & logistics | 1959 |
| Squirrel Hospitality Limited | Hospitality | 2019 |
| SR Auto Dynamics Ltd | Wholesale & retail | 2025 |
| SR Flooring Stockist Limited | Wholesale & retail | 2023 |
| SR Heating & Electrical Services Limited | Manufacturing | 2016 |
| SR Hvac Service Ltd | Construction | 2013 |
| SR Living Ltd | Wholesale & retail | 2019 |
| SR Luxury Ltd | Wholesale & retail | 2025 |
| SR Property Developers Ltd | Real estate | 2024 |
| SR Traders Limited | Wholesale & retail | 2012 |
| SRA Trading Ltd | Hospitality | 2023 |
| SRB Groceries Limited | Hospitality | 2025 |
| SRC Holdings Limited | Construction | 2001 |
| SRE Associates Ltd | Health & social care | 2022 |