| Skill Construction Ltd | Construction | 2025 |
| Skilled Home Services Limited | Construction | 2024 |
| Skillgame Limited | Manufacturing | 1984 |
| Skills 4 YOU First AID Ltd | Education | 2025 |
| Skimsound Limited | | 1980 |
| Skincentric Limited | Health & social care | 2021 |
| Skintopia Lights Limited | Other services | 2016 |
| Skinzy Ltd | Wholesale & retail | 2025 |
| Skirting 4 U Limited | Manufacturing | 2013 |
| Skittles.School Limited | Education | 2017 |
| SKK Learning Ltd | Education | 2018 |
| SKM IT Consultants Limited | Information & communication | 2008 |
| Skoa Hospitality Ltd | Professional & scientific | 2024 |
| SKP Cleaning Ltd | Administrative & support | 2023 |
| Skrw Ltd | Administrative & support | 2014 |
| SKS Alliance Ltd | Real estate | 2019 |
| Skull and Chin Barbers Limited | Other services | 2017 |
| Sky EQP Ltd | Wholesale & retail | 2026 |
| Sky High Staffing Limited | Administrative & support | 2022 |
| Sky Property Rentals Ltd | Real estate | 2024 |
| Skyblue Recruitment Limited | Construction | 2007 |
| Skyline Living Limited | Real estate | 2026 |
| Skyline Resourcing Limited | Administrative & support | 2007 |
| Skyroutetravels Ltd | Administrative & support | 2025 |
| Skysoft Properties UK Ltd | Real estate | 2018 |
| Skyway Tours & Travel Ltd | Other services | 2015 |
| SL Traders Ltd | Wholesale & retail | 2026 |
| SL UK Services Limited | Manufacturing | 2020 |
| Slab Publishing Limited | Information & communication | 2021 |
| Slam My Van Ltd | Wholesale & retail | 2020 |
| Slash Holdings (WM) Ltd | Financial services | 2025 |
| Slateley Holdings Ltd | Financial services | 2026 |
| Slaw-Trans Ltd | Transport & logistics | 2016 |
| Slayboujie Ltd | Other services | 2022 |
| Slaycart Ltd | Wholesale & retail | 2025 |
| SLC Building Services Ltd | Construction | 2018 |
| SLC Properties (Aston) Ltd | Real estate | 2019 |
| Sleek Limited | Real estate | 2023 |
| Slicesndices Ltd | Hospitality | 2026 |
| Slick Customs Ltd | Wholesale & retail | 2020 |
| Slightly Unusual Ltd | Arts & recreation | 2013 |
| Slipform Limited | Administrative & support | 2015 |
| Sliw Transport Ltd | Transport & logistics | 2024 |
| Slns Foods Ltd | Hospitality | 2025 |
| SLR Brickwork Limited | Construction | 2023 |
| SLT Developments Limited | Construction | 2021 |
| SLT Plumbing Ltd | Construction | 2026 |
| Sluk Ltd | Wholesale & retail | 2022 |
| Slush World Limited | Hospitality | 2012 |
| SM Barbers Ltd | Other services | 2026 |
| SM Bricklaying Ltd | Construction | 2021 |
| SM Butchers and Groceries Limited | Wholesale & retail | 2021 |
| SM Khan Properties Ltd | Real estate | 2025 |
| SM Pharmco Limited | Wholesale & retail | 2023 |
| SM Prop Investments Ltd | Real estate | 2025 |
| SM Services Midlands Limited | Manufacturing | 2007 |
| Small Dog Rescue Cliveglen | Other services | 2020 |
| Small Heath Plant Hire Limited | Administrative & support | 2010 |
| Smar Construction Limited | Construction | 2024 |
| Smart BIZ (Europe) Ltd | Wholesale & retail | 2014 |
| Smart BNB Ltd | Hospitality | 2023 |
| Smart Building Contractors Ltd | Other services | 2018 |
| Smart Business Matters Ltd | Other services | 2017 |
| Smart Business Works Ltd | Wholesale & retail | 2025 |
| Smart Living Property Limited | Real estate | 2019 |
| Smart Power Energy Solutions Limited | Administrative & support | 2018 |
| Smart Property Solutions (Midlands) Ltd | Real estate | 2018 |
| Smart Solutions Holdings Ltd | Financial services | 2020 |
| Smart Southam Ltd | Construction | 2018 |
| Smart Step Holdings Ltd | Real estate | 2017 |
| Smart Trader FDN Ltd | Wholesale & retail | 2017 |
| Smart Vending UK Ltd | Wholesale & retail | 2026 |
| Smart Water Coolers Limited | Extraterritorial | 2003 |
| Smarten AI Ltd | Water & waste | 2025 |
| Smartlec UK Electrical Services Ltd | Construction | 2025 |
| Smartlyst Ltd | Wholesale & retail | 2025 |
| Smartpluz Properties Ltd | Real estate | 2025 |
| Smartpro Limited | Information & communication | 2011 |
| Smartprop Online Limited | Administrative & support | 2017 |
| Smartronic Midlands Limited | Other services | 2016 |
| Smartserve Packaging Ltd | Wholesale & retail | 2025 |
| Smartz Security UK Ltd | Administrative & support | 2022 |
| Smash & Stack Ltd | Hospitality | 2024 |
| Smash Signs Ltd | Other services | 2015 |
| Smashburger Cannock Ltd | Hospitality | 2025 |
| Smashburgers Enterprise Ltd | Hospitality | 2025 |
| Smat Extra Ltd | Professional & scientific | 2022 |
| Smctruehomes Ltd | Real estate | 2026 |
| SME Smart Savings Ltd | Extraterritorial | 2019 |
| Smell Fabulous NOW Limited | Other services | 2025 |
| SMG Lettings Limited | Real estate | 2013 |
| SMI Grill Limited | Hospitality | 2022 |
| Smile Choices Limited | Health & social care | 2011 |
| Smilerecruitment Ltd | Administrative & support | 2025 |
| Smiles by JK Ltd | Health & social care | 2026 |
| Smiles by Rajesh Beedh Ltd | Health & social care | 2022 |
| Smiley K Limited | Wholesale & retail | 2021 |
| Smile’S Physio Limited | Other services | 2025 |
| Smith & Parker Holdings Ltd | Financial services | 2017 |
| Smith Business Services Limited | Administrative & support | 2018 |