| Doghouse Renovations Limited | Real estate | 2024 |
| Dolcec Ltd | Information & communication | 2025 |
| Dolls Tanning Group Gateshead Ltd | Other services | 2025 |
| Dolls Tanning Group Kenton Ltd | Other services | 2025 |
| Dolls Tanning Group Wallsend Ltd | Other services | 2025 |
| Double Dose Limited | Wholesale & retail | 2025 |
| DP Damp Proofing Limited | Construction | 2020 |
| DPB Food Services Private Ltd | Hospitality | 2022 |
| DRA PAT Testing Limited | Professional & scientific | 2012 |
| Drakestone Developments Limited | Real estate | 2007 |
| Drakestone Investments Limited | Real estate | 2007 |
| Dravek Holdings Ltd | Professional & scientific | 2026 |
| Dreamshine Community Interest Company | Administrative & support | 2019 |
| Dreamworx Club Ltd | Arts & recreation | 2024 |
| Driveopen Limited | Manufacturing | 1998 |
| Driving From A2B Ltd | Education | 2023 |
| Druidess Ltd | Arts & recreation | 2024 |
| DSG Fabrication Limited | Manufacturing | 2022 |
| Dsg-Bim Ltd | Manufacturing | 2018 |
| Dsg-Modular Limited | Manufacturing | 2016 |
| DSW Windows & Doors Ltd | Construction | 2021 |
| DTC & DG Developments Ltd | Real estate | 2022 |
| Ductwork Damper Maintenance Ltd | Construction | 2019 |
| Dunewell Services Ltd | Wholesale & retail | 2026 |
| Dunne Building Supplies Ltd | Wholesale & retail | 2025 |
| Durham Fabrication and Weld Services Ltd | Manufacturing | 2025 |
| Durham Security Group Ltd | Administrative & support | 2022 |
| Durham Security Limited | Administrative & support | 2023 |
| Durham Security Services Ltd. | Administrative & support | 2019 |
| Durhamlane Limited | Administrative & support | 2011 |
| DV Textiles Trade Ltd | Wholesale & retail | 2025 |
| Dvelectrical Ltd | Construction | 2024 |
| Dwelling Roofing Ltd | Construction | 2019 |
| DWT Engineering Limited | Professional & scientific | 2003 |
| Dylano Ltd | Wholesale & retail | 2025 |
| Dynamic Heating (North East) Ltd. | Construction | 2013 |
| Dynamic Plumbing & Heating Services Ltd | Construction | 2018 |
| Dynatech Renewables Ltd | Energy | 2022 |
| E-Don IT Consultancy Ltd | Information & communication | 2011 |
| E.L.E. Retail Limited | Wholesale & retail | 2013 |
| EA Renewables Ltd | Professional & scientific | 2024 |
| East Durham Properties Ltd | Real estate | 2026 |
| East END Security Services Limited | Public administration | 2025 |
| East Shore Mortgages Ltd | Financial services | 2026 |
| Eastend Futures CIC | Other services | 2026 |
| Eastfield Roofing Ltd | Construction | 2014 |
| Eastlake Productions Ltd | Arts & recreation | 2025 |
| Easy Solution Info Tech Limited | Information & communication | 2019 |
| Ecls 2025 Limited | Extraterritorial | 2007 |
| Ecls Group Limited | Professional & scientific | 2022 |
| Ecomrade PPC Ltd | Professional & scientific | 2025 |
| Ecostream Brokerage (ESB) Ltd | Wholesale & retail | 2025 |
| Eevolution Battery Systems Ltd | Manufacturing | 2021 |
| Efesalnwick Limited | Hospitality | 2025 |
| Efe’S Turkish Grill House Ltd | Hospitality | 2025 |
| EHA Property Services Ltd | Real estate | 2023 |
| Eiffage Metal UK Limited | Construction | 2015 |
| Elavarasi Ltd | Wholesale & retail | 2022 |
| ELE Distribution Ltd | Wholesale & retail | 2022 |
| Electrical Solutions (North East) Limited | Wholesale & retail | 2015 |
| Elfriska Limited | Hospitality | 2019 |
| Elite High Court Enforcement Ltd | Administrative & support | 2014 |
| Elite UK Homes (Formby) Ltd | Construction | 2024 |
| Elite UK Homes Bryant House Ltd | Construction | 2024 |
| Elite UK Padel Ltd | Arts & recreation | 2026 |
| ELM Farm Cottage Limited | Construction | 2024 |
| Elva Bella Ltd | Wholesale & retail | 2026 |
| Embrace Law Ltd | Professional & scientific | 2021 |
| Emily Taylor Aesthetics Nurse Ltd | Other services | 2022 |
| Emily Ward Art Limited | Arts & recreation | 2022 |
| Emma Jordan Weddings Limited | Hospitality | 2023 |
| Emma Pizza & Grill Ltd | Hospitality | 2017 |
| Emmott and SON Removal and Storage Ltd | Transport & logistics | 2020 |
| Energies Moins Cheres Ltd | Administrative & support | 2015 |
| Enright Consultancy Limited | Education | 2013 |
| Enviable Group Limited | Information & communication | 2016 |
| EPC Holdings Ltd | Real estate | 2025 |
| Equal Partnerships Ltd | Health & social care | 2009 |
| Equals (Entitlement and Quality Education for Pupils With Learning Difficulties) | Education | 2007 |
| Equinox IP Limited | Construction | 2006 |
| ERT North Tech Ltd | Professional & scientific | 2026 |
| Eson Salon Supplies Limited | Wholesale & retail | 2014 |
| Essarrdee Ltd | Wholesale & retail | 2012 |
| Essential (Nordics) Limited | Professional & scientific | 2024 |
| Eurodirect Ltd | Financial services | 2022 |
| Eurotyres Recycling Limited | Water & waste | 2012 |
| Evak Limited | Manufacturing | 2000 |
| Everduty Flex Staffing Solutions Ltd | Administrative & support | 2024 |
| Evolve Home Improvements Ltd | Construction | 2023 |
| Exact Edge Limited | Manufacturing | 2025 |
| Expresso Property (Fulwood) Limited | Construction | 2021 |
| Expresso Property (Perth) Limited | Construction | 2015 |
| Exsafe International Ltd | Construction | 2015 |
| EYE Food Ltd | Hospitality | 2019 |
| Ezee Sips Ltd | Construction | 2019 |
| F & P Accountancy Services Limited | Professional & scientific | 2022 |
| F a NCL Ltd | Hospitality | 2019 |
| F.L.T. Solutions Ltd | Extraterritorial | 2019 |
| F.O.X Enineering Limited | Construction | 2016 |
| FA North East Ltd | Real estate | 2024 |