| RB Joinery NE Limited | Construction | 2018 |
| RB Kitchen NE Limited | Construction | 2018 |
| RBB Services NE Ltd | Construction | 2025 |
| Ready Fresh Ltd | Hospitality | 2019 |
| Realestate Campus Ltd | Education | 2023 |
| Red Earth Holdings Limited | Health & social care | 2018 |
| Red Moon (NE) Ltd | Hospitality | 2019 |
| Redrod Rental Ltd | Real estate | 2025 |
| Refresh Renovations NE Ltd | Construction | 2023 |
| Refynd Global Limited | Wholesale & retail | 2025 |
| Regents FM Solutions Limited | Professional & scientific | 2009 |
| Reid Framing Limited | Wholesale & retail | 2003 |
| Renroc Enterprises Limited | Information & communication | 2017 |
| Renroc Industries Ltd | Information & communication | 2024 |
| Renshaw Property Limited | Real estate | 2026 |
| Review Hives Ltd | Professional & scientific | 2025 |
| Rezizt Products Limited | Manufacturing | 2022 |
| RGH Housing Limited | Real estate | 2022 |
| RGH Real Estate Limited | Real estate | 2014 |
| RHS Rapid Heating Solutions Ltd | Construction | 2020 |
| Ricco's Pizza Ltd | Hospitality | 2025 |
| Richardson Holdings NE Ltd | Financial services | 2026 |
| Richy's Developments Limited | Real estate | 2006 |
| Rigging & Haulage Solution's Ltd | Mining & quarrying | 2022 |
| Rigging World Ltd | Arts & recreation | 2022 |
| Right Choice 4 Beds Limited | Wholesale & retail | 2010 |
| Right Choice Cleaning Services Ltd | Administrative & support | 2018 |
| Right Here Consulting Ltd | Professional & scientific | 2025 |
| Rio's Piri Piri Newcastle Ltd | Hospitality | 2025 |
| Rio's Piri Piri Wallsend Ltd | Hospitality | 2025 |
| River Birch Newman Limited | Administrative & support | 2023 |
| Riviera Resources Limited | Real estate | 2021 |
| RL Motors (NE) Ltd | Wholesale & retail | 2026 |
| RM Events NE Ltd | Hospitality | 2025 |
| RM Foods Grainger Ltd | Hospitality | 2025 |
| RM Foods North East Ltd | Hospitality | 2023 |
| RM Sales Consultants Ltd | Wholesale & retail | 2025 |
| RNC Engineering Ltd | Construction | 2025 |
| RNC Property Services Ltd | Real estate | 2021 |
| Roamer Robotics Ltd | Education | 2022 |
| ROB Gibson JET Washing Services Ltd | Administrative & support | 2021 |
| ROB Gibson Window Cleaning Service Ltd | Administrative & support | 2013 |
| Robertson & Sons L & V Limited | Manufacturing | 2016 |
| Robinson Automotive Ltd | Professional & scientific | 2026 |
| Robyn Hood Holdings Limited | Financial services | 2026 |
| Robyn Hood Housing Consultancy Limited | Professional & scientific | 2026 |
| ROC Engineering Ltd | Professional & scientific | 2012 |
| Rock N Rolls NE Ltd | Hospitality | 2025 |
| Rockbit Facilities Limited | Manufacturing | 2020 |
| Rockbit RIG Sales Limited | Professional & scientific | 2017 |
| Rockbit Services Limited | Manufacturing | 2018 |
| Rockbit UK Limited | Manufacturing | 2003 |
| Rocktech Group Ltd | Mining & quarrying | 2024 |
| Rogue One Custom Campers North East Ltd | Wholesale & retail | 2017 |
| Rolls Enterprises Limited | Hospitality | 2000 |
| Ronnswood Investments Limited | Real estate | 2022 |
| Rope Access Piping Solutions Limited | Construction | 2017 |
| Ropeaccesstradeservices Ltd | Manufacturing | 2024 |
| Roro Design Limited | Professional & scientific | 2002 |
| Rose & REN Ltd | Hospitality | 2026 |
| Rowan Legal Costs Ltd | Professional & scientific | 2011 |
| Royal Clean NE Ltd | Administrative & support | 2020 |
| Royaltee Hairs and Accessories Ltd | Wholesale & retail | 2025 |
| RPG Worldwide Services Limited | Construction | 2014 |
| RPW Lifting Limited | Construction | 2019 |
| RRM Project Services Ltd | Professional & scientific | 2024 |
| Ruchitas Wallsend Limited | Hospitality | 2026 |
| Runhead Forge Limited | Other services | 1985 |
| Ryans Collections Limited | Other services | 2014 |
| Ryukyu Ltd | Wholesale & retail | 2021 |
| S and G Housing Management Ltd | Real estate | 2025 |
| S Brown Traffic Management Limited | Construction | 2017 |
| S Burnip Ltd | Other services | 2025 |
| S G Home Improvements Ltd | Construction | 2021 |
| S R Bain Enterprise Ltd | Construction | 2015 |
| S W Caravan Services Ltd | Manufacturing | 2025 |
| S&L Commerce Ltd | Wholesale & retail | 2020 |
| S.L Farming Services Limited | Agriculture & fishing | 2012 |
| Safesteps Care and Support Ltd | Administrative & support | 2026 |
| Sage Wellness Collective Ltd | Other services | 2026 |
| Sajadi Properties Ltd | Real estate | 2023 |
| Salem Tl&A Group of Companies Ltd | Wholesale & retail | 2025 |
| Samantha's Legacy CIC | Hospitality | 2021 |
| Sanctuary Law Ltd | Professional & scientific | 2018 |
| Sanctum Games and Collectables Ltd | Wholesale & retail | 2024 |
| Saraswati Sky Psychological Services and Holistic Therapies Ltd | Health & social care | 2021 |
| SB81 Pipe and Weld Ltd | Construction | 2019 |
| Scarpa (UK) Limited | Extraterritorial | 1994 |
| Scent Trade Limited | Wholesale & retail | 2022 |
| Scoop Beauty Ltd | Wholesale & retail | 2020 |
| Scorpious (Bramley) Ltd | Construction | 2024 |
| Scorpious (Eckington) Ltd | Construction | 2023 |
| Scorpious (Glapwell) Ltd | Construction | 2023 |
| Scorpious (Renishaw) Ltd | Construction | 2023 |
| Scorpious (South Normanton) Ltd | Construction | 2025 |
| Scorpious (Woodhouse) Ltd | Construction | 2024 |
| Scorpious 1 Ltd | Real estate | 2023 |
| Scorpious Eckington School Ltd | Construction | 2024 |
| Scott Robertson IT Limited | Information & communication | 2015 |
| Scott Waters Limited | Construction | 2019 |