| North Road Car Sales (1982) Limited | Wholesale & retail | 1982 |
| North Road Garage (North East) Ltd | Wholesale & retail | 2017 |
| North Star (NS) Ltd | Hospitality | 2025 |
| North Tyneside Academy Foundation | Education | 2012 |
| Northbound Automations Ltd | Information & communication | 2026 |
| Northdec Facilities Ltd | Construction | 2020 |
| Northeast Building Upgrading Landscapes Advancement Limited | Construction | 2026 |
| Northeast Coaching Ltd | Education | 2025 |
| Northeastwelding Ltd | Professional & scientific | 2025 |
| Northern Air Ltd | Construction | 2021 |
| Northern Animal Assisted Therapies and Activities (Naata) CIC | Education | 2019 |
| Northern Bites Ltd | Hospitality | 2025 |
| Northern Community Power Community Interest Company | Professional & scientific | 2011 |
| Northern Electronic Services Ltd | Administrative & support | 2016 |
| Northern Heights Roofing Ltd | Construction | 2025 |
| Northern Property Services Ltd | Real estate | 2021 |
| Northpoint Associates Limited | Professional & scientific | 2005 |
| Northstar 3PL Limited | Administrative & support | 2025 |
| Northstar Living Care Limited | Health & social care | 2026 |
| Northsummit Property Partners Ltd | Real estate | 2026 |
| Northumberland Construction Ltd | Construction | 2025 |
| Northumberland FA Community Hub Limited | Arts & recreation | 2023 |
| Northumberland Football Association Limited | Arts & recreation | 1999 |
| Northumbria Caravan Services Ltd | Manufacturing | 2020 |
| Northumbria Flooring Limited | Wholesale & retail | 2015 |
| Northumbria Flooring Outlet Ltd | Wholesale & retail | 2019 |
| Northumbria Mobile Caravan Services Ltd | Manufacturing | 2020 |
| Northumbrian Hot TUB Holidays Ltd | Hospitality | 2017 |
| Norvex MTA Ltd | Wholesale & retail | 2026 |
| Nova Trading AB Ltd | Wholesale & retail | 2026 |
| NRG Fixers Ltd | Construction | 2024 |
| NSG Construction Ltd | Construction | 2024 |
| NTJ Brickwork Ltd | Construction | 2021 |
| NU Space Homes (Acomb) Limited | Construction | 2018 |
| Nudo Sushi Box (Manchester) Ltd | Hospitality | 2015 |
| Nudo Sushi Box Ltd | Hospitality | 2012 |
| Nuveil Limited | Professional & scientific | 2024 |
| NWO Industries Limited | Hospitality | 2021 |
| O'Gorman Trading Co Ltd | Wholesale & retail | 2024 |
| O.B.E Roofing Ltd | Construction | 2022 |
| Oakhouse Capital Ltd | Information & communication | 2015 |
| Oana Lespezanu Pharm Services Ltd | Health & social care | 2024 |
| Odeete Media Limited | Professional & scientific | 2024 |
| Offshore Dynamics Ltd | Energy | 2023 |
| Oglofus Ltd | Information & communication | 2023 |
| OH Brow Aesthetics Limited | Other services | 2024 |
| OJ Property Ltd | Real estate | 2025 |
| Okonkwo Ltd | Health & social care | 2023 |
| Oliver Construction N E Ltd | Construction | 2019 |
| Oliver Offshore Ltd | Other services | 2025 |
| OLK Enterprises Ltd | Wholesale & retail | 2022 |
| Omniio Labs Ltd | Information & communication | 2025 |
| ON Site Engineering Ltd | Professional & scientific | 2024 |
| ON the Kusp Limited | Professional & scientific | 2020 |
| One Care Solution Ltd | Health & social care | 2019 |
| One HDS (England) Limited | Professional & scientific | 2010 |
| One Landscapes Ltd | Professional & scientific | 2013 |
| One Step Care (Holdings) Limited | Financial services | 2022 |
| One Step Care Limited | Health & social care | 2016 |
| Onit Web Solutions Limited | Information & communication | 2008 |
| Only Homely Limited | Construction | 2025 |
| Oofacorn Limited | Professional & scientific | 2020 |
| Opal Branded Limited | Wholesale & retail | 2025 |
| Opal North East Limited | Education | 2019 |
| Oppenheimers Original Paint (1864) Limited | Manufacturing | 2018 |
| Opulence Heating & Bathrooms Limited | Construction | 2020 |
| Order Things Ltd | Information & communication | 2024 |
| Orion OS Ltd | Information & communication | 2025 |
| Ormston Property Services Ltd | Real estate | 2025 |
| Oscar Armstrong Limited | Wholesale & retail | 2025 |
| OTR Distribution (UK) Ltd | Wholesale & retail | 2013 |
| OUR Children's World Limited | Education | 2017 |
| Over the Edge Labour Ltd | Professional & scientific | 2016 |
| Overdale Engineering Ltd | Professional & scientific | 2023 |
| OWE Holdings Ltd | Households | 2025 |
| Oxbeak Ltd | Wholesale & retail | 2024 |
| P & S Rentals Ltd | Real estate | 2021 |
| P H Preservation Group Limited | Construction | 2020 |
| Page Powder Coatings Limited | Professional & scientific | 2004 |
| PAJ Leisure Ltd | Hospitality | 2022 |
| Pantomonium Limited | Education | 2021 |
| Paramount Care (Gateshead) Limited | Health & social care | 2012 |
| Paranormal Atlas Ltd | Wholesale & retail | 2026 |
| Park Road Deli Ltd | Wholesale & retail | 2024 |
| Parmo Punks Ltd | Hospitality | 2020 |
| Patterson Ryan Limited | Manufacturing | 2001 |
| Pattinson Holiday Lets Limited | Real estate | 2012 |
| Paul Balbirnie E & I Inspection Limited | Manufacturing | 2012 |
| Paul Nicholson (N.E) Ltd | Transport & logistics | 2016 |
| Paul Watson Fabrication Limited | Manufacturing | 2017 |
| Pavé Bars Ltd | Hospitality | 2025 |
| PBS (NE) Ltd | Construction | 2019 |
| PC Fone and Vape TEK Ltd | Wholesale & retail | 2025 |
| PC Gamer Whole Sales Ltd | Wholesale & retail | 2026 |
| PCA Leisure Ltd | Hospitality | 2026 |
| Peacock Leisure Ltd | Hospitality | 2025 |
| Pear Tree Design Limited | Professional & scientific | 2024 |
| Pearson Holdings (NE) Ltd | Financial services | 2021 |
| Pearson Travel Limited | Transport & logistics | 2020 |
| Pearson's Roofing & Property Maintenance Ltd | Construction | 2023 |