| SAN Care Limited | Health & social care | 2013 |
| SAN Tech Systems Limited | Information & communication | 2011 |
| Sanctum Living Ltd | Wholesale & retail | 2024 |
| Sand Capital Advisory Limited | Construction | 2016 |
| Sandsago Limited | Hospitality | 2008 |
| Sarah Christie Limited | Other services | 2005 |
| Sarah Shepherd Limited | Other services | 2012 |
| Sarahcam Limited | Professional & scientific | 2007 |
| Sarko Enterprises UK Ltd | Wholesale & retail | 2026 |
| Sarwah Limited | Real estate | 2024 |
| SAS Software Services Limited | Information & communication | 2015 |
| Sasn Ltd | Wholesale & retail | 2023 |
| Sassy Box Ltd | Health & social care | 2018 |
| Satsa Ltd | Wholesale & retail | 2022 |
| Satyasingh Limited | Health & social care | 2017 |
| Savage Innovations Limited | Professional & scientific | 2018 |
| Savings Hub Ltd | Administrative & support | 2016 |
| Saxon House Freehold Limited | Households | 2016 |
| Saymr Limited | Construction | 2020 |
| SB Active March Ltd | Other services | 2023 |
| SB Casas Ltd | Real estate | 2019 |
| SBT Investments Limited | Wholesale & retail | 2018 |
| SC International Consultancy Ltd | Administrative & support | 2021 |
| Scan Electronics Ltd | Administrative & support | 2013 |
| Scan Property Ltd | Real estate | 2020 |
| Scara Mechanical Ltd | Construction | 2024 |
| Scientific AI Limited | Information & communication | 2018 |
| Scihero Limited | Professional & scientific | 2023 |
| SCM Solutions (UK) Ltd | Other services | 2013 |
| Scotscape Green Limited | Other services | 2018 |
| Scotscape Landscaping Limited | Other services | 2000 |
| Scotscape Smartscape Limited | Agriculture & fishing | 2018 |
| Scott Leaver Heating Services Ltd | Construction | 2014 |
| SCR FC Limited | Arts & recreation | 2026 |
| Scylla Select Ltd | Information & communication | 2017 |
| Sdmcomputers Ltd | Transport & logistics | 2014 |
| SDO Holdings Limited | Professional & scientific | 2018 |
| SDP Property Limited | Real estate | 2021 |
| SDR Carpentry & Construction Ltd | Extraterritorial | 2025 |
| Sdventure Holdings Limited | Financial services | 2024 |
| SE1 Psychotherapy Ltd | Health & social care | 2018 |
| Seagle Ltd | Financial services | 2018 |
| Search Marketing Company Limited | Professional & scientific | 1999 |
| Sebastian Komar Building Services Ltd | Construction | 2018 |
| Sebson Homes Ltd | Real estate | 2022 |
| Seci Property Investments Ltd | Real estate | 2020 |
| Secretarial Services KDG Ltd | Administrative & support | 2017 |
| Security Options (UK) Ltd | Administrative & support | 2012 |
| SED Ltd | Professional & scientific | 2022 |
| Seductive Beauty UK Ltd | Administrative & support | 2024 |
| Seegreen Enterprises Ltd | Information & communication | 2018 |
| Seeing Solutions Management Services Ltd | Professional & scientific | 2013 |
| Selebration Limited | Hospitality | 2025 |
| Selsdon Smithy Limited | Professional & scientific | 2014 |
| Semita Regulatory Limited | Professional & scientific | 2026 |
| Semo's Consultancy Services Limited | Professional & scientific | 2022 |
| SEN & SEN Limited | Hospitality | 2023 |
| Senpal Education Limited | Education | 2017 |
| Sense Communications & PR Limited | Professional & scientific | 2012 |
| Sensible Living Limited | Real estate | 2023 |
| Serendipity EUR Ltd | Professional & scientific | 2014 |
| Serendipity Series Ltd | Hospitality | 2022 |
| Service Solutions (UK) Limited | Professional & scientific | 2003 |
| SET Production Limited | Construction | 2021 |
| Sevenhillsdigital Ltd | Information & communication | 2018 |
| Sevenoaks Subs Ltd | Hospitality | 2025 |
| Seventh Seal Youth Programme (Ssyp) CIC | Education | 2023 |
| Seylon Foods Limited | Wholesale & retail | 2023 |
| Sfhc Ltd | Health & social care | 2026 |
| Sfra Ltd | Wholesale & retail | 2021 |
| SHA Trading Limited | Extraterritorial | 2013 |
| Shadowfleet Limited | Professional & scientific | 2023 |
| Shami Enterprises Ltd | Transport & logistics | 2025 |
| Sharps Scaffolding Services Ltd | Construction | 2023 |
| Shaun Whiting Limited | Information & communication | 2015 |
| Shaw Information Services Ltd | Professional & scientific | 2012 |
| Shazam Tax Ltd | Professional & scientific | 2014 |
| SHB Roofing Ltd | Construction | 2021 |
| Sheila Fraser Whyte Limited | Education | 2024 |
| Shelbourne Homes Limited | Construction | 2015 |
| Sher Moon Limited | Arts & recreation | 2024 |
| Sheridan Electrical Ltd | Construction | 2023 |
| Sheryl Online Ltd | Wholesale & retail | 2025 |
| Sheth&Shah Ltd | Real estate | 2021 |
| Shilpi's Kitchen Limited | Hospitality | 2024 |
| Shirdenzo Ltd | Health & social care | 2026 |
| Shital Travels Ltd | Administrative & support | 2023 |
| Shiyam Homes (12A Fairdene Road) Ltd | Construction | 2025 |
| Shiyam Homes Ltd | Real estate | 2021 |
| Shiyam Limited | Construction | 2020 |
| Shko Barbers Ltd | Other services | 2022 |
| Shootcutplay Ltd | Information & communication | 2022 |
| Shoppers Choice Limited | Wholesale & retail | 2021 |
| Shore Communications Ltd | Information & communication | 2002 |
| Shrihari and Company (UK) Limited | Professional & scientific | 2019 |
| Shriram and Company Limited | Education | 2011 |
| Shuffled Ltd | Wholesale & retail | 2026 |
| Shwana Electrical Services Ltd | Manufacturing | 2022 |
| SHY Billy Productions Ltd | Arts & recreation | 2025 |
| SI Belle by Ghazala Ltd | Wholesale & retail | 2023 |