| D.R. Holdings (North West) Limited | Financial services | 2021 |
| D.R. Property (North West) Limited | Real estate | 2021 |
| DA Electrical Northwest Ltd | Professional & scientific | 2012 |
| Dairy Exchange Limited | Wholesale & retail | 2010 |
| Dairy Express Ltd | Wholesale & retail | 2025 |
| Dale Court Heswall Limited | Households | 1983 |
| Daley Dwellings Ltd | Real estate | 2024 |
| Dalglish Limited | Hospitality | 2018 |
| Dallingers Funeral Directors Limited | Other services | 2025 |
| Dalton Manor Limited | Manufacturing | 2025 |
| Dandelion Promotions Limited | Professional & scientific | 2026 |
| Danefield Properties Limited | Real estate | 2001 |
| Dangi Ltd | Wholesale & retail | 2018 |
| Danzfit Ltd | Arts & recreation | 2021 |
| Darinip BIZ Ltd | Wholesale & retail | 2024 |
| Dave Foster Construction Limited | Construction | 2022 |
| Davenports Properties Ltd | Real estate | 2023 |
| David Magee & Company Limited | Administrative & support | 1989 |
| David Magee Photography Limited | Professional & scientific | 2017 |
| David Wallas Ltd | Construction | 2024 |
| Davolt Ecci Ltd | Construction | 2025 |
| DC Maintenance & Developments Ltd | Other services | 2025 |
| Dcgltd Ltd | Construction | 2025 |
| DCL Electrical Northwest Limited | Professional & scientific | 2023 |
| Dclpubco Limited | Hospitality | 2025 |
| DDH Investments Ltd | Professional & scientific | 2018 |
| DDI Education Limited | Professional & scientific | 2015 |
| DE Jonge Digital Ltd | Professional & scientific | 2024 |
| Deadwood Arborists Tree Care Specialists Ltd | Agriculture & fishing | 2021 |
| Dean Nicholas Consulting Limited | Information & communication | 2023 |
| Deborah Health Spa Ltd | Real estate | 2026 |
| Decent Digs Ltd | Hospitality | 2024 |
| Deco Developments Limited | Real estate | 2025 |
| Deerchair Ltd | Wholesale & retail | 2024 |
| Deeside Gymnastics Club Limited | Arts & recreation | 2016 |
| Definition Football Limited | Education | 2020 |
| Defyne Beauty Ltd | Other services | 2024 |
| Deheat Ltd | Professional & scientific | 2022 |
| Demand Property Ltd | Real estate | 2022 |
| Demax Convenience Ltd | Wholesale & retail | 2024 |
| Den-Tech Solutions Ltd | Other services | 2021 |
| Denis Tiger Property Limited | Real estate | 2024 |
| Dereks Building Services Limited | Construction | 2011 |
| Design & Drawing Projects 482 Limited | Professional & scientific | 2019 |
| Design Analytics Ltd | Information & communication | 2013 |
| Designated Associates Limited | Information & communication | 1994 |
| Designated Design Limited | Professional & scientific | 2008 |
| Desire Property Management Ltd Ltd | Households | 2024 |
| Devalera Productions Limited | Information & communication | 2025 |
| Dexter Real Estate Limited | Real estate | 2016 |
| DG Services NW Ltd | Construction | 2022 |
| DHW Property Holdings Ltd | Real estate | 2026 |
| Diadochus Limited | Financial services | 2024 |
| Digital Performance Technology Ltd | Professional & scientific | 2021 |
| Digitally Transform Dental IT Consultancy Ltd | Information & communication | 2018 |
| Digitally Transform ME Limited | Information & communication | 2018 |
| Dilman Limited | Hospitality | 2024 |
| Dimension Design and Building Services Limited | Wholesale & retail | 2007 |
| Disability Transportation Services Limited | Transport & logistics | 2023 |
| District House CH45 Limited | Hospitality | 2023 |
| Diva Design Facilities Limited | Other services | 2011 |
| Diverse Digital Group CIC | Information & communication | 2026 |
| DJ LEE Butler Limited | Arts & recreation | 2019 |
| Django Import Ltd | Wholesale & retail | 2019 |
| Django Retail Ltd | Wholesale & retail | 2020 |
| DJC Homes Ltd | Real estate | 2019 |
| DJM Windows & Doors Limited | Construction | 2022 |
| DJP Technical Solutions Ltd | Information & communication | 2010 |
| DK Carpentry & Joinery Ltd | Construction | 2016 |
| Dkmssolutions Ltd | Manufacturing | 2025 |
| DLP Consultants Limited | Professional & scientific | 2007 |
| Dmurphy Holdings Ltd | Financial services | 2020 |
| DNA 3 Retail Ltd | Wholesale & retail | 2020 |
| DNH Commercial Solutions Ltd | Professional & scientific | 2020 |
| Dnjss Holdings Ltd | Financial services | 2021 |
| Docexcel Limited | Administrative & support | 2019 |
| Dock Road Tyres Limited | Wholesale & retail | 2025 |
| Dodgshons Bakery Limited | Wholesale & retail | 2009 |
| Dooleys (Dockside) Ltd | Hospitality | 2018 |
| Door Check Fire Door Inspections Ltd | Public administration | 2022 |
| Dorvid Limited | Professional & scientific | 2023 |
| Dosa Factory Limited | Hospitality | 2024 |
| Dough Media Ltd | Information & communication | 2025 |
| DP Finance Solutions Ltd | Financial services | 2019 |
| DPM Contractors NW Ltd | Construction | 2026 |
| Dqdt Training and Consulting Limited | Professional & scientific | 2023 |
| DR Alan Corrin Limited | Health & social care | 2008 |
| DR. Amanda Bowen Ltd | Health & social care | 2026 |
| Draintube Limited | Water & waste | 2016 |
| Drawlim Services Ltd | Construction | 2025 |
| Dream Body HFN Limited | Health & social care | 2019 |
| Drexmere Holdings Ltd | Financial services | 2025 |
| DRP Mobility Limited | Transport & logistics | 2025 |
| DS & KC @ the Woodhouse Ltd | Hospitality | 2024 |
| DS & KC Properties Ltd | Real estate | 2026 |
| DS Construction NW Ltd | Construction | 2016 |
| DS Electrical Services NW Ltd | Construction | 2019 |
| DS Surgical Ltd | Health & social care | 2021 |
| DTG Commerce Ltd | Wholesale & retail | 2024 |
| DTR Services Limited | Construction | 2020 |