| Zedsoft Limited | Information & communication | 2019 |
| Zeejay Ltd | Wholesale & retail | 2025 |
| Zeld Learning Solutions Ltd | Professional & scientific | 2021 |
| ZEN Beauty & Clinical Limited | Other services | 2018 |
| Zengi Limited | Wholesale & retail | 2015 |
| Zengiva Ltd | Wholesale & retail | 2024 |
| Zenn Sleep Ltd | Manufacturing | 2026 |
| Zenomax Ltd | Wholesale & retail | 2018 |
| Zephyr Surgery Holdings Ltd | Financial services | 2025 |
| Zephyr Surgery Investments Ltd | Financial services | 2025 |
| Zest & Punch Limited | Professional & scientific | 2020 |
| Zetland Investment Properties (ZIP) Ltd | Real estate | 2025 |
| ZH Pharma Ltd | Wholesale & retail | 2023 |
| Zhoufuzeng Limited | Wholesale & retail | 2025 |
| ZIA Logistics Limited | Transport & logistics | 2018 |
| ZIA Sweets Limited | Wholesale & retail | 2021 |
| ZIB 1CARS Ltd | Administrative & support | 2023 |
| Ziche Hair and Beauty Salon Limited | Other services | 2024 |
| Ziche Limited | Health & social care | 2023 |
| Zion & Jael Property Services Ltd | Real estate | 2024 |
| Zion Chapel Management Company Limited | Households | 2004 |
| Zippertech Limited | Manufacturing | 1999 |
| Ziroz Limited | Health & social care | 2026 |
| ZLC Property Limited | Real estate | 2019 |
| ZOE Bakes Ltd | Manufacturing | 2026 |
| Zoe's Home Animal Rescue CIC | Other services | 2023 |
| Zone Homes Limited | Construction | 2003 |
| Zootalore! Consulting Ltd | Administrative & support | 2023 |
| ZOW Ltd | Manufacturing | 2025 |
| Zschaler Ltd | Extraterritorial | 2014 |
| Zubenubi Maritime Ltd | Professional & scientific | 2024 |
| Zulu's Healthcare Ltd | Health & social care | 2014 |
| Zuxta Ltd | Hospitality | 2024 |
| Zuzannagasiewicz Ltd | Real estate | 2025 |
| Zwolan Construction Ltd | Construction | 2016 |
| Zyblock Ltd | Information & communication | 2025 |
| Zyle Transport Limited | Transport & logistics | 2025 |
| Zzizii Properties Ltd | Real estate | 2026 |
| Élixir Privé Ltd | Other services | 2025 |