| Elwood Trading Ltd | Professional & scientific | 2022 |
| Elyte Healthcare Resourcing Ltd | Health & social care | 2024 |
| Emal Trading Ltd | Financial services | 2026 |
| Embaarkks Limited | Construction | 2015 |
| Embassy Court (Ruislip) Residents Association Limited | Households | 1981 |
| Embryo Music Limited | Information & communication | 2012 |
| Emchic Ltd | Hospitality | 2025 |
| Emerald Lion Photo Booths Limited | Professional & scientific | 2014 |
| Emerald Property Holdings Ltd | Real estate | 2020 |
| Emeraldpoint Limited | Health & social care | 1995 |
| Emery's Building Company Ltd | Construction | 2021 |
| EMF Guardian Ltd | Wholesale & retail | 2024 |
| EMG Beauty Ltd | Other services | 2025 |
| Emil-Josh Ltd | Financial services | 2017 |
| Eminent Solutions Limited | Information & communication | 2025 |
| Emira Properties Limited | Real estate | 2023 |
| Emlea Flooring & Home Improvements Ltd | Construction | 2023 |
| Emlea House Ltd | Health & social care | 2021 |
| Emlea Housing Group Ltd | Households | 2022 |
| Emlea Lodge Ltd | Health & social care | 2022 |
| Emlea Property Services Ltd | Households | 2021 |
| Emotibalance Ltd | Arts & recreation | 2024 |
| Empathicx Limited | Professional & scientific | 2025 |
| Empire Contractors Co. Limited | Construction | 2017 |
| Empire Group Ltd | Real estate | 2014 |
| Empire Sound Limited | Arts & recreation | 2018 |
| Empower Counselling Limited | Health & social care | 2020 |
| Empowermental Ltd | Health & social care | 2023 |
| Empress Court (Luton) Management Limited | Households | 2007 |
| Enableall Limited | Information & communication | 2021 |
| Enahgee Productions Ltd | Wholesale & retail | 2011 |
| Encho (UK) Limited | Construction | 2016 |
| Eneprox Ltd | Information & communication | 2024 |
| Energian UK Limited | Professional & scientific | 2012 |
| Energize Technologies Ltd | Manufacturing | 2025 |
| Energy Light Bulbs Ltd | Wholesale & retail | 2010 |
| Energybit Limited | Professional & scientific | 2018 |
| Energyflow Partners Limited | Wholesale & retail | 2020 |
| Enfield Eats Ltd | Wholesale & retail | 2024 |
| Enforcement Training and Services Ltd | Other services | 2024 |
| Engaging Eyes Ltd. | Wholesale & retail | 2007 |
| Engocha Express Ltd | Transport & logistics | 2025 |
| Enhance IT Services Limited | Other services | 2015 |
| Enigma London Ltd | Arts & recreation | 2022 |
| Enlightened Experiences Limited | Information & communication | 2007 |
| Enndrajoti Limited | Construction | 2014 |
| Ennis Consultancy Limited | Professional & scientific | 2018 |
| ENO Services Limited | Construction | 2012 |
| Enoch Christian Counselling Service Ltd | Health & social care | 2020 |
| Enoch Human Capital Ltd | Administrative & support | 2024 |
| ENT IMM Ltd | Professional & scientific | 2002 |
| Enter Mars Ltd | Information & communication | 2018 |
| Enterprise Technology Solutions Inc Limited | Wholesale & retail | 2013 |
| Envirohoard Limited | Extraterritorial | 2008 |
| Enwind Ltd | Health & social care | 2021 |
| EOP Electrical Services Ltd | Construction | 2025 |
| Eosthenix Ltd | Wholesale & retail | 2024 |
| EP VIP Group Ltd | Professional & scientific | 2022 |
| Epicuro Protective Materials Limited | Wholesale & retail | 2021 |
| Epoch-Making Toys Limited | Wholesale & retail | 2013 |
| EQL Solutions Limited | Education | 2013 |
| Equation Associates Limited | Administrative & support | 2004 |
| Equicare Services Ltd | Health & social care | 2013 |
| Equity Financial Ltd | Financial services | 2020 |
| Equity Managed Services Group Limited | Financial services | 2019 |
| Equity Networks Limited | Information & communication | 2010 |
| Equity Real Estate (Hindhead) Ltd | Real estate | 2016 |
| Equity Real Estate (LEO) Ltd | Administrative & support | 2016 |
| Equity Real Estate (Rushworth) Ltd | Administrative & support | 2016 |
| ER Worldwide Co., Ltd | Arts & recreation | 2020 |
| Erba Diagnostics UK Limited | Financial services | 2015 |
| ERF Media Ltd | Professional & scientific | 2025 |
| Ergon Engineering Ltd | Construction | 2022 |
| Ernest Jackson & Co. Limited | Manufacturing | 1916 |
| Eroy Ltd | Manufacturing | 2014 |
| Ersu Ltd | Hospitality | 2019 |
| Erudite Learning Limited | Education | 2022 |
| Esanu Construct Ltd | Construction | 2021 |
| Escrow JAN Goldenberg Limited | Professional & scientific | 2025 |
| Esher Auto Car Wash Ltd | Wholesale & retail | 2024 |
| Esher Road Properties Limited | Real estate | 2018 |
| Essential Store Ltd | Wholesale & retail | 2025 |
| Essiah Group Limited | Health & social care | 2025 |
| Estate Asset Management Ltd | Real estate | 2025 |
| Estate Rents Ltd | Real estate | 2026 |
| Estates Optimum Ltd | Real estate | 2023 |
| Esteem Motor Group Ltd | Wholesale & retail | 2022 |
| Esther Goldstern (UK) Ltd | Financial services | 2019 |
| Estmanco (Union Road) Limited | Households | 1980 |
| ET Enterprises Limited | Manufacturing | 2007 |
| Etalon Brickworks Ltd | Construction | 2021 |
| Etalon Group Ltd | Construction | 2022 |
| Etalon Holding Ltd | Financial services | 2019 |
| Etalon Logistics Ltd | Transport & logistics | 2019 |
| Etalon Plant & Scaffolding Ltd | Construction | 2023 |
| Etas Limited | Information & communication | 1997 |
| Etch&Fable Limited | Manufacturing | 2025 |
| Eternal Wedding Decor Ltd | Arts & recreation | 2023 |
| Ethan Berry Cricket Hub Ltd | Wholesale & retail | 2025 |
| Ethan Property Holdings Ltd | Real estate | 2022 |