| Seralena Holdings Limited | Administrative & support | 2017 |
| Serenia Software Limited | Professional & scientific | 2002 |
| SET POD Lighting Limited | Administrative & support | 2021 |
| Sett of Keys Ltd | Wholesale & retail | 2020 |
| Seven 0 Two Ltd | Administrative & support | 2021 |
| Seven 0 Two Property Group Ltd | Construction | 2026 |
| Seven Loves Limited | Information & communication | 2024 |
| Seventh AGE Films Ltd | Administrative & support | 2024 |
| Seventh AGE Pictures Limited | Arts & recreation | 2017 |
| Sewme Limited | Administrative & support | 2025 |
| Seymour Beale Limited | Professional & scientific | 2018 |
| Seymour Court Management (1994) Limited | Real estate | 1993 |
| Seyri Cafe Ltd | Hospitality | 2024 |
| Seyri Turkish Restaurant Ltd | Hospitality | 2025 |
| SF Elevate Limited | Manufacturing | 2024 |
| SF Express (Europe) Co. Ltd | Transport & logistics | 2016 |
| SF Intra-City Delivery (UK) Limited | Transport & logistics | 2022 |
| SFR Auto Ltd | Wholesale & retail | 2018 |
| SGG Foods Ltd | Hospitality | 2018 |
| Sgsg Limited | Administrative & support | 2015 |
| SHA Group Ltd | Hospitality | 2019 |
| Shack Entertainment Limited | Arts & recreation | 2023 |
| Shaergy Limited | Professional & scientific | 2022 |
| Shaftesbury Enterprises Limited | Professional & scientific | 2003 |
| Shan Community Ltd | Information & communication | 2025 |
| Shanawaz Express Ltd | Hospitality | 2016 |
| Shangri LA Real Estate Ltd | Real estate | 2020 |
| Share My Home Limited | Hospitality | 2017 |
| Share Pilates Limited | Arts & recreation | 2015 |
| Sharetons Ltd | Other services | 2018 |
| Sharp Traders PVT Limited | Wholesale & retail | 2022 |
| Sharpe Refinery Service (Hydro Carbons) Limited | Real estate | 1978 |
| Shastra Limited | Information & communication | 2019 |
| Shaw Productions Ltd | Arts & recreation | 2022 |
| Shawstone Associates Ltd | Professional & scientific | 2012 |
| Shayla Developers Limited | Construction | 2017 |
| Shearwater Property Ltd | Real estate | 2024 |
| Sheen Craft Build Limited | Construction | 2025 |
| Sheen Craft Joinery Limited | Manufacturing | 2022 |
| Sheesh Ascot Ltd | Construction | 2019 |
| Shehaj Company Limited | Construction | 2025 |
| Shek Architects Ltd | Professional & scientific | 2020 |
| Shelby's Steak & Burger House Limited | Hospitality | 2025 |
| Shepperton Covers Ltd | Manufacturing | 2022 |
| Shepperton Design Studios Marketing Limited | Arts & recreation | 2012 |
| Sher Hair Studio Ltd | Extraterritorial | 2024 |
| Sheraton Design & Build London Limited | Other services | 2020 |
| Sheraton Interiors Limited | Other services | 2016 |
| Sherwood Electrical Ltd | Other services | 2015 |
| Shifty Media Ltd | Professional & scientific | 2022 |
| Shijo Ltd | Real estate | 2025 |
| Shika Tsuru Pictures Ltd. | Information & communication | 2019 |
| Shimmeya Limited | Real estate | 2022 |
| Shine Offline Limited | Other services | 2016 |
| Shire Mews (Numbers 1-8) Residents Management Company Limited | Households | 2021 |
| Shiuli Restaurants Limited | Hospitality | 2021 |
| Shivale Limited | Real estate | 2025 |
| Shootaz Ltd | Wholesale & retail | 2025 |
| Short Game Golf Academy Limited | Education | 2023 |
| Shot London Group Ltd | Hospitality | 2022 |
| Shot London Ltd | Hospitality | 2022 |
| Showmen Times Limited | Information & communication | 2020 |
| Showpony Music Ltd | Information & communication | 2009 |
| Shurgard Roofing Ltd | Construction | 2025 |
| Shutter Showcase Ltd | Professional & scientific | 2024 |
| Shyla Consulting Limited | Real estate | 2015 |
| Sibyl Arts Limited | Information & communication | 2020 |
| Sift Cakes Limited | Hospitality | 2015 |
| Signtrack Studios Limited | Professional & scientific | 2026 |
| Sikunder Ltd | Health & social care | 2025 |
| Silver Leaf Holdings Limited | Construction | 2020 |
| Silverba Limited | Information & communication | 2026 |
| Silverbridge-Lugo Trading Limited | Financial services | 2019 |
| Silverhug Ltd | Wholesale & retail | 2022 |
| Silverplay Limited | Arts & recreation | 2012 |
| Silverwood Consulting Limited | Professional & scientific | 2014 |
| Simbe Consulting Ltd | Professional & scientific | 2024 |
| Simon Brown Architects Limited | Professional & scientific | 2020 |
| Simon Fresh Foods Ltd Ltd | Hospitality | 2026 |
| Simon Lipman Photographer Limited | Arts & recreation | 2014 |
| Simpal.Ai Ltd | Information & communication | 2023 |
| Simple Services and Needs Limited | Construction | 2026 |
| Simply Done Services Ltd | Construction | 2023 |
| Simply Soulful Ltd | Health & social care | 2020 |
| Simply the Best Professional Services Ltd | Administrative & support | 2017 |
| Simplí Basic Limited | Wholesale & retail | 2020 |
| Simsul Ltd | Health & social care | 2016 |
| Sinclair Spencer Ltd | Information & communication | 2014 |
| Singing Hands Limited | Education | 2012 |
| Singing Hands Merchandise Limited | Education | 2010 |
| Sirisha`S Health & Beauty Ltd | Wholesale & retail | 2008 |
| Sit-Up Channels Limited | Wholesale & retail | 2020 |
| Situate Global Limited | Administrative & support | 2021 |
| Siva Yogan & Co Limited | Administrative & support | 2017 |
| Sixes Entertainment Franchise Limited | Professional & scientific | 2026 |
| Sixes Entertainment Limited | Hospitality | 2026 |
| Sixteen Sixty Theatre Ltd | Education | 2020 |
| SJ Technical Limited | Professional & scientific | 2024 |
| SJB Property Holdings Limited | Real estate | 2021 |
| SJB Property Limited | Real estate | 2016 |