| D.C Plumbing & Heating (Wilts) Ltd | Construction | 2024 |
| D.J. Bewley Funeral Directors Limited | Other services | 2001 |
| D2SN Limited | Manufacturing | 2015 |
| Dacing BEE Developments Limited | Manufacturing | 2025 |
| Daffodil House Limited | Real estate | 2022 |
| Dagilca Limited | Real estate | 2021 |
| Dajam Limited | Construction | 1992 |
| Dakg Limited | Construction | 2026 |
| DAM Lettings Ltd | Real estate | 2020 |
| Dancing BEE Developments Ltd | Professional & scientific | 2025 |
| Daniel Butler Electrical Limited | Construction | 2018 |
| Darko Developments Ltd | Construction | 2018 |
| Darnie Capital Ltd | Professional & scientific | 2024 |
| Datadriven Solutions Ltd | Information & communication | 2014 |
| Dave Naughton Electrical Services Limited | Construction | 2014 |
| David Arthur Consulting Limited | Professional & scientific | 2005 |
| David Bishop Ltd | Professional & scientific | 2014 |
| David Gibson Buildings Limited | Construction | 2013 |
| Davies Home Improvements South West Ltd | Construction | 2021 |
| DB Coffees Express Ltd | Hospitality | 2022 |
| DB MAX Events Ltd | Professional & scientific | 2016 |
| DB MAX Limited | Arts & recreation | 2012 |
| DCD Handyman Services Limited | Construction | 2026 |
| DDH Psychology Ltd | Education | 2024 |
| Dead Badger Clothing Co Ltd | Wholesale & retail | 2025 |
| Dead Good Content Limited | Professional & scientific | 2013 |
| Deanima Limited | Wholesale & retail | 2013 |
| Dees Design Ltd | Professional & scientific | 2020 |
| Dell Inspired Construction Limited | Construction | 2020 |
| Deluxe Hospitality Ltd | Hospitality | 2015 |
| Dementia@Home Ltd | Health & social care | 2021 |
| Dent Wise Removal Limited | Manufacturing | 2016 |
| Design Group International Ltd | Professional & scientific | 2000 |
| Design ME a Heat Pump Ltd | Construction | 2024 |
| Devereux & Huskie Glassworks Ltd | Manufacturing | 2013 |
| DG Car Sales Wiltshire Limited | Wholesale & retail | 2018 |
| DH3 Construction Ltd | Construction | 2020 |
| Diamond News Ltd | Wholesale & retail | 2021 |
| Didi Melville Press Ltd | Information & communication | 2024 |
| Difontaine Limited | Information & communication | 2013 |
| Diggers R US Ltd | Wholesale & retail | 2024 |
| Digital Design Wessex Ltd | Professional & scientific | 2023 |
| Dinger Developments Limited | Wholesale & retail | 2023 |
| Dirty Cats Motorcycles Ltd | Wholesale & retail | 2023 |
| Discovery Spinal Care Limited | Health & social care | 2020 |
| Distinctive Wristwear Ltd | Wholesale & retail | 2024 |
| DK Locksmiths and Double Glazing Repairs Ltd | Construction | 2022 |
| DL Management (Wilts) Ltd | Construction | 2017 |
| DMR (Wiltshire) Ltd | Real estate | 2021 |
| DN Automotive VMS Ltd | Manufacturing | 2008 |
| Dominique Goltinger Ltd | Hospitality | 2024 |
| Donald Road Management Company Limited | Households | 2007 |
| Dotline Limited | Professional & scientific | 1987 |
| Dough&Co Trowbridge Limited | Hospitality | 2021 |
| Drivescape Ltd | Construction | 2015 |
| DRM Holdings 2025 Ltd | Financial services | 2026 |
| DS Studio 555 Limited | Other services | 2022 |
| DSC Contractors Ltd | Manufacturing | 2020 |
| DTL Happy Homes Limited | Real estate | 2025 |
| DTL Retail Limited | Wholesale & retail | 2026 |
| Duck's Haulage Limited | | 1981 |
| Duffy Restoration Ltd | Real estate | 2025 |
| Duncans Retail Limited | Wholesale & retail | 2011 |
| DVS Property Management Ltd | Real estate | 2021 |
| Dynamic Innovations Limited | Wholesale & retail | 2018 |
| E & R Etherington Limited | Arts & recreation | 2011 |
| E House Connect Ltd | Real estate | 2013 |
| E J Shanley & SON Ltd | Extraterritorial | 2012 |
| Eagle Grounds Maintenance Limited | Administrative & support | 2015 |
| EAP Linguistics Limited | Professional & scientific | 2016 |
| Earlina Ltd | Wholesale & retail | 2024 |
| Early Years Schoolwear Limited | Wholesale & retail | 2012 |
| Easy Accounts and Tax Ltd | Professional & scientific | 2018 |
| Easy Home Group Ltd | Real estate | 2021 |
| EAT5STAR Limited | Hospitality | 2008 |
| Eaton Architecture Limited | Professional & scientific | 2025 |
| Editall Ltd | Professional & scientific | 2022 |
| Edward & Co Ltd | Real estate | 2013 |
| Edward Oatley and SON (Marsh Farm) Limited | Agriculture & fishing | 1959 |
| Edward Oatley and SON Limited | Agriculture & fishing | 1955 |
| Edwards Vending Ltd | Wholesale & retail | 2022 |
| Effat Limited | Transport & logistics | 2014 |
| Egebox Ltd | Wholesale & retail | 2025 |
| Egerton Sport Horses Ltd | Agriculture & fishing | 2024 |
| Egret Medteq Ltd | Professional & scientific | 2014 |
| Eight Hills Ltd | Wholesale & retail | 2014 |
| Ejfventures Ltd | Education | 2026 |
| EL Camino Espresso Ltd | Wholesale & retail | 2025 |
| EL Sali Services Ltd | Health & social care | 2025 |
| Eldred Design Limited | Information & communication | 2013 |
| Elite Auto Care Trowbridge Ltd | Wholesale & retail | 2026 |
| Elite Ladies Dance ELT Ltd | Arts & recreation | 2026 |
| Elite Ladies Dance LIV Ltd | Arts & recreation | 2025 |
| Elite Uniforms Ltd | Wholesale & retail | 2012 |
| Elizabeth Snell & Family Ltd | Other services | 2015 |
| Ellen - Elite Juniors Dance Ltd | Arts & recreation | 2024 |
| Ellen - Elite Ladies Dance Ltd | Arts & recreation | 2024 |
| Ellen F Holdings Ltd | Financial services | 2026 |
| Ellie's Spuds Ltd | Hospitality | 2025 |
| Elliot Rhodes International Ltd | Extraterritorial | 2019 |