| Dashazh Production Limited | Other services | 2022 |
| Data Consultancy Services Limited | Information & communication | 2017 |
| Data Goals Limited | Information & communication | 2023 |
| David Alexander Knowles Limited | Wholesale & retail | 2015 |
| David Cairns Ltd | Information & communication | 2014 |
| David Mustow Limited | Arts & recreation | 2004 |
| Davidfulchergolf Ltd | Arts & recreation | 2012 |
| Davidson Roberts Developments Limited | Other services | 2023 |
| Davidson Roberts Enterprises Limited | Education | 2022 |
| DBS Logistics Ltd | Transport & logistics | 2020 |
| DC Freestyle Limited | Arts & recreation | 2015 |
| DCL Catering Limited | Hospitality | 2021 |
| DD Bookkeeping Limited | Professional & scientific | 2026 |
| DE LA Isla Limited | Manufacturing | 2024 |
| Dead Ball Media Ltd | Information & communication | 2025 |
| Dean Hall Estate Limited | Financial services | 2025 |
| Debbie Murphy Ltd | Information & communication | 2017 |
| Decadec Limited | Real estate | 2014 |
| Decesare Beauty Limited | Other services | 2003 |
| Deckies Limited | Wholesale & retail | 2021 |
| Deez Clothing Limited | Wholesale & retail | 2023 |
| Delicious Place Ltd | Hospitality | 2020 |
| Deliver Aviation Ltd | Professional & scientific | 2023 |
| Delta Creative Ltd | Professional & scientific | 2019 |
| Delta Display (Leicester) Limited | Construction | 2001 |
| Demeter Advisers Limited | Professional & scientific | 2024 |
| Derry Civils Ltd | Construction | 2021 |
| Desborough Computing Limited | Professional & scientific | 1998 |
| Design & Build Projects Ltd. | Professional & scientific | 2000 |
| Deskcentre Technology Limited | Information & communication | 1997 |
| DG Preece Associates Limited | Real estate | 2002 |
| DGC Consulting Limited | Construction | 2024 |
| DH Mortgages and Protection Ltd | Financial services | 2025 |
| DH Property Management Company Ltd | Households | 2014 |
| Diamond Hard Surfaces Limited | Manufacturing | 2004 |
| Diet Connect Limited | Wholesale & retail | 1995 |
| Digi-Healthcare Limited | Professional & scientific | 2025 |
| Digital Fusion LAB Ltd | Information & communication | 2025 |
| Digital Origin Holdings Ltd | Information & communication | 2017 |
| Digital Origin Solutions Ltd | Information & communication | 2000 |
| Digital Print Management Limited | Manufacturing | 2001 |
| DIH 2011 Limited | Hospitality | 2011 |
| Dimension 3 Design Ltd | Professional & scientific | 2010 |
| Dinc Limited | Administrative & support | 2004 |
| Dinger Ltd | Administrative & support | 2013 |
| Dingo and JOE Ltd | Wholesale & retail | 2025 |
| Direct Transfer Hub Limited | Manufacturing | 2024 |
| Directhub Ltd | Manufacturing | 2021 |
| Disabled Adventurer CIC | Information & communication | 2019 |
| Disporum Limited | Professional & scientific | 2009 |
| Diva Capital Ltd | Financial services | 2025 |
| Diva Gift Ltd | Wholesale & retail | 2019 |
| Diva Group Ltd | Wholesale & retail | 2020 |
| Diva Package Ltd | Wholesale & retail | 2019 |
| Diva Properties Ltd | Wholesale & retail | 2024 |
| Diva Store Ltd | Wholesale & retail | 2021 |
| Diversityscope Limited | Construction | 2004 |
| DJ Hutchings & Sons Limited | Construction | 2017 |
| DJ Marquees Limited | Hospitality | 2007 |
| DJM Precision Engineering Ltd | Professional & scientific | 2008 |
| Dolce Lilla Ltd | Wholesale & retail | 2025 |
| Dominic Gammond Consulting Ltd | Information & communication | 2022 |
| Donald Cook's Limited | Wholesale & retail | 1915 |
| Donerium Limited | Hospitality | 2026 |
| Doppler Media Ltd | Information & communication | 2021 |
| Dorum Associates Limited | Professional & scientific | 2004 |
| Down to Earth (Farthingstone) Limited | Administrative & support | 2005 |
| DPO Lifts Limited | Construction | 2021 |
| DPW Financial Services Limited | Financial services | 2017 |
| DR Gagan Swami Limited | Health & social care | 2024 |
| DR Nkechi Jane Anosike Ltd | Health & social care | 2025 |
| Drone Detection Solutions Limited | Administrative & support | 2017 |
| Druesta Silverworks Ltd | Manufacturing | 2020 |
| DS Management Ltd | Professional & scientific | 2023 |
| DSG Lettings Limited | Real estate | 2020 |
| DSJ & RM Limited | Professional & scientific | 2024 |
| Ducathen Limited | Professional & scientific | 2019 |
| Ducati U.K. Limited | Wholesale & retail | 1999 |
| Duck Construction Limited | Construction | 2026 |
| Dumarey Flybrid Limited | Manufacturing | 2018 |
| Dunlin Holdings Limited | Financial services | 2023 |
| Dunlin Properties Limited | Construction | 2002 |
| DW & AW Leisure Ltd | Hospitality | 2019 |
| Dynamic Commercial Finance Ltd | Administrative & support | 2021 |
| E 3 Engineering Services Ltd | Construction | 2009 |
| E Corbett Consulting Ltd | Information & communication | 2019 |
| E Lloyd Construction Limited | Construction | 2026 |
| E M Property Solutions Limited | Real estate | 2017 |
| E Porter Properties Ltd | Real estate | 2025 |
| E-Pro GAS Services Limited | Construction | 2024 |
| E. M. Plant Hire & Groundworks Ltd | Administrative & support | 2005 |
| E3 Mhlg Holdings Ltd | Real estate | 2020 |
| Each&All Ltd | Professional & scientific | 2012 |
| Eaglesphere Limited | Financial services | 2022 |
| Eastcote Consulting LLP | | 2013 |
| Eastcote Technology Limited | Professional & scientific | 2010 |
| Eastgate Wealth Management Limited | Financial services | 2009 |
| Eastwood Finance Ltd | Financial services | 2022 |
| Eazertech Ltd | Manufacturing | 2024 |
| Eccentric Engineering Ltd | Manufacturing | 2019 |