| EMO Trans Limited | Transport & logistics | 2002 |
| Empire Services (SW) Ltd | Construction | 2022 |
| Employment Solutions SW Ltd | Administrative & support | 2024 |
| Empson CS Limited | Administrative & support | 2016 |
| EMS Renovations Ltd | Construction | 2014 |
| END Zone Limited | Arts & recreation | 2025 |
| Endymion House (Teignmouth) Management Company Limited | Households | 2020 |
| Energy Compagny Limited | Construction | 2020 |
| Energy Zone (UK) Ltd | Professional & scientific | 2011 |
| Engin Cutz Ltd | Other services | 2025 |
| English Riviera BID Company Limited | Administrative & support | 2016 |
| English Riviera Estate Ltd | Financial services | 2024 |
| Enlighten Inns Limited | Hospitality | 2008 |
| Enlightenhr Limited | Administrative & support | 2004 |
| Ennerdale (Torquay) Flat Management Ltd | Hospitality | 2013 |
| Enoch Properties (Devon) Limited | Real estate | 1977 |
| Enotee Ltd | Wholesale & retail | 2022 |
| Enterprise South West Ltd | Hospitality | 2017 |
| Environment Protection Agency Ltd | Administrative & support | 2022 |
| Eoxys Limited | Administrative & support | 2008 |
| EPH Torquay Ltd | Hospitality | 2025 |
| Epic Homecare Limited | Health & social care | 2021 |
| Epiphany Building Solutions Limited | Construction | 2025 |
| Epos Systems Limited | Wholesale & retail | 2000 |
| Equinox Gaming Ltd | Administrative & support | 2025 |
| Eric Jones Limited | Real estate | 2017 |
| Eridez Limited | Wholesale & retail | 2020 |
| ERL Support Services Limited | Extraterritorial | 2018 |
| Escape Artists Limited | Arts & recreation | 2002 |
| Essam Construction Ltd | Construction | 2026 |
| Essential 6 Ltd | Education | 2007 |
| Essential Chiro Limited | Health & social care | 2013 |
| Essential GAS & Plumbing Limited | Construction | 2012 |
| ESSENTIAL2U Limited | Administrative & support | 2007 |
| ET Caetera Limited | Information & communication | 2014 |
| Etioga Limited | Health & social care | 2011 |
| Etiopathe Limited | Other services | 2015 |
| Evador Site Services Limited | Manufacturing | 2014 |
| Eveil & Conscience Limited | Other services | 2018 |
| Event Medical Solutions [SW] CIC | Health & social care | 2014 |
| Eventail Limited | Professional & scientific | 2026 |
| Everett Marine Limited | Professional & scientific | 2017 |
| Everglades Hotel Ltd | Hospitality | 2018 |
| Evergrace Healthcare Ltd | Health & social care | 2025 |
| Everyone Succeeds Ltd | Information & communication | 2025 |
| Everything Womanly Ltd | Information & communication | 2021 |
| Eviction Support Group Limited | Professional & scientific | 2023 |
| EWS Consultants Ltd | Professional & scientific | 2025 |
| Excalibur Management Services Limited | Real estate | 1992 |
| Excell Health Ltd | Administrative & support | 2024 |
| Excell Healthcare Ltd | Administrative & support | 2022 |
| Excellent Care Staffing Service Ltd | Administrative & support | 2025 |
| Excelsior Solutions Consultancy Ltd | Professional & scientific | 2020 |
| Excolo Consulting Ltd | Real estate | 2019 |
| Exeter Concrete Pumping (SW) Ltd | Construction | 2018 |
| Exeter Concrete Pumping Limited | Extraterritorial | 2012 |
| Exmouth Quay Management Company Limited | Households | 1996 |
| Expo Branding Direct Ltd | Professional & scientific | 2025 |
| Exportstocklots Limited | Wholesale & retail | 2026 |
| Express Fire Limited | Other services | 2020 |
| Expurtle Ltd | Information & communication | 2022 |
| F.I.J. Building Services Ltd | Construction | 2011 |
| F.O.J. Properties Limited | Real estate | 2024 |
| Fables Bookshop Limited | Wholesale & retail | 2006 |
| Facial Secrets Limited | Health & social care | 2010 |
| Facility Services South West Ltd | Administrative & support | 2022 |
| FAD Real Estate Limited | Real estate | 2026 |
| Fade Zone TQ Ltd | Other services | 2023 |
| Faggi Publicite Limited | Professional & scientific | 2003 |
| Fairdale Management Company (Teignmouth) Limited | Households | 2006 |
| Fairlawns Management Company (Paignton) Limited | Households | 2003 |
| Fairleigh Residents Management Company Limited | Households | 2021 |
| Fairlight (1994) Limited | Professional & scientific | 1994 |
| Fairwaters Management Limited | Households | 2020 |
| Fallapit Barns Limited | Households | 2002 |
| Falmouth Business Park Limited | Administrative & support | 2015 |
| FAR Reach Ltd | Hospitality | 2020 |
| Farnborough House (Torquay) Management Company Limited | Households | 2003 |
| Farrell Contractors Ltd | Construction | 2005 |
| Farrell Solutions Limited | Transport & logistics | 2018 |
| Farthing Lane Limited | Extraterritorial | 2021 |
| FASTTECH4U Ltd | Manufacturing | 2020 |
| Favis of Salcombe Limited | Agriculture & fishing | 2014 |
| Faze Internet Limited | Information & communication | 2003 |
| FC Payroll Solutions Limited | Professional & scientific | 1998 |
| Feeling Young Ltd | Education | 2019 |
| Felco Developments Limited | Construction | 2002 |
| Fenster Fabrications Limited | Manufacturing | 2013 |
| Fenston Stamps Limited | Wholesale & retail | 2026 |
| Fenworth (U.K.) Limited | Hospitality | 1976 |
| Fernlea (Torquay) Limited | Real estate | 1995 |
| Ferrymans Reach Limited | Real estate | 1997 |
| FIA Ahmad Ltd | Wholesale & retail | 2025 |
| Fidelity Absolute Ltd | Extraterritorial | 2026 |
| Fieldfare Country Foods Limited | Agriculture & fishing | 2005 |
| Fifty Point Four Limited | Wholesale & retail | 2020 |
| Fijbs Holdings Limited | Financial services | 2025 |
| Filament Works CIC | Education | 2020 |
| Filby Flat Ltd | Real estate | 2025 |
| Filmwrightproductions Ltd | Information & communication | 2024 |