| Studio Moshi Moshi Limited | Administrative & support | 2006 |
| Studio on the Square Ltd | Real estate | 2006 |
| Studio Tech Consulting Limited | Professional & scientific | 2021 |
| Studio Verina Ltd | Manufacturing | 2025 |
| Studysync Ltd | Education | 2023 |
| STX Studio Limited | Wholesale & retail | 2021 |
| Style Still Limited | Other services | 2023 |
| Sublata Ltd | Financial services | 2026 |
| Subscribe Limited | Financial services | 2015 |
| Substratum Controls Ltd | Information & communication | 2026 |
| Subzero Software Limited | Information & communication | 2008 |
| Sudisu Ltd | Hospitality | 2016 |
| Suleman Shipping Ltd | Wholesale & retail | 2024 |
| Sullivan Building & Maintenance Ltd | Construction | 2014 |
| Sullivan Crafted Ltd | Manufacturing | 2026 |
| Sultani GAS Limited | Wholesale & retail | 2016 |
| Summer Couture Ltd | Wholesale & retail | 2015 |
| Summers Partnership Limited Liability Partnership | | 2008 |
| Summit Consulting & Assistance Ltd | Financial services | 2025 |
| Summit Gardens Limited | Administrative & support | 2014 |
| Summit Management Solutions Limited | Information & communication | 2005 |
| Sumnut Farms Limited | Agriculture & fishing | 1961 |
| Sumtech Electrical Ltd | Construction | 2020 |
| Sunflower Business Change Consultants Limited | Administrative & support | 2016 |
| Sunnylucky Limited | Real estate | 1980 |
| Sunrise Press Limited | Information & communication | 2021 |
| Sunshine Solar Installations Ltd | Construction | 2025 |
| Supersparx Ltd | Construction | 2025 |
| Superyacht Compare Limited | Wholesale & retail | 2025 |
| Supreme Glazing Solutions Limited | Construction | 2018 |
| Surf Investments Ltd | Real estate | 2006 |
| Surge Electrical Services Limited | Construction | 2003 |
| Surrenden Court Management Limited | Households | 2014 |
| Surrey Hills Joinery Ltd | Manufacturing | 2021 |
| Surtrade LLP | | 2024 |
| Susam Tonbridge Ltd | Hospitality | 2024 |
| Sushi Samurai Ltd | Hospitality | 2025 |
| Sussex Firewood Ltd | Wholesale & retail | 2026 |
| Sussex Vascular Surgeons Limited | Health & social care | 2024 |
| Sustainability Specialists Ltd | Professional & scientific | 2024 |
| Sustainable Impact Ventures Ltd | Professional & scientific | 2020 |
| Sutton Court Farms Limited | Professional & scientific | 2014 |
| Suzi Doyle Limited | Health & social care | 2015 |
| SVM PMO Consultancy Services Limited | Professional & scientific | 2025 |
| SVS TEK Ltd | Information & communication | 2014 |
| SW18 Properties Limited | Real estate | 2017 |
| Swallows Oast Getaways Limited | Hospitality | 2014 |
| Swamy Medical Services Ltd | Health & social care | 2026 |
| Swan Family Enterprise Limited | Professional & scientific | 2022 |
| Swan Financial Services Limited | Professional & scientific | 2015 |
| Swanmead Sports Association | Arts & recreation | 2011 |
| Swanspurs Properties Limited | Real estate | 2020 |
| Swarm by Nature Limited | Information & communication | 2019 |
| Swatch Interior Design UK Limited | Administrative & support | 2020 |
| Swaylands Estate Management Limited | Households | 2004 |
| Sweet Caroline Lodge Limited | Real estate | 2025 |
| Sweet-About-Me Ltd | Hospitality | 2016 |
| Sweetpea's Bakehouse Ltd | Hospitality | 2021 |
| Swift 100 Limited | Real estate | 2016 |
| Swift Alarms Ltd | Administrative & support | 2018 |
| Swift Axis Limited | Wholesale & retail | 2026 |
| Swift Valley Partnership LLP | | 2007 |
| Swift-Fix Roofing Ltd | Construction | 2026 |
| Swiftmed International Ltd | Transport & logistics | 2018 |
| Swim With ME Kent Ltd | Education | 2026 |
| Swimseal UK Limited | Manufacturing | 2012 |
| Swinda Medical Ltd | Health & social care | 2016 |
| Switch Property Ltd | Real estate | 2018 |
| SWS Solutions (UK) Ltd | Wholesale & retail | 2012 |
| Sylva Woodland Management Ltd | Agriculture & fishing | 2013 |
| Symonds Salvage Limited | Wholesale & retail | 2002 |
| Synapse Advisory Ltd | Professional & scientific | 2021 |
| Syneider Clothing Limited | Extraterritorial | 2010 |
| Syneider Foods Limited | Wholesale & retail | 2026 |
| Syneider MEN Clothing Limited | Wholesale & retail | 2014 |
| Synergy (GB) Limited | Administrative & support | 2002 |
| Synergy in Kent Limited | Health & social care | 2023 |
| Synon Medical Limited | Professional & scientific | 2011 |
| T & M Developments (UK) Limited | Other services | 2013 |
| T C TEO Plastic Surgery Ltd | Health & social care | 2019 |
| T R Media Limited | Information & communication | 2009 |
| T REX Global Ltd | Information & communication | 2025 |
| T Walters Racing Ltd | Agriculture & fishing | 2014 |
| T&T Consulting Group Ltd | Professional & scientific | 2026 |
| T-You.Com Limited | Administrative & support | 2007 |
| T.& H.King Limited | Agriculture & fishing | 1903 |
| T.D.& Partners Ltd | Transport & logistics | 2021 |
| T.F. & R.D. Stephens Limited | Wholesale & retail | 1974 |
| T.O.O.T Services Ltd | Professional & scientific | 2023 |
| T2D Holdings Limited | Real estate | 2020 |
| TA Homes (Land) Limited | Real estate | 2018 |
| Tabb Signs Limited | Manufacturing | 2026 |
| Tabger Captial Ltd | Real estate | 2017 |
| Tabor Court Limited | Real estate | 2002 |
| TAG Media Limited | Professional & scientific | 2006 |
| TAG Safe Limited | Construction | 2017 |
| TAG Surveying Limited | Professional & scientific | 2021 |
| TAH Properties Holdings Limited | Real estate | 2026 |
| TAH Properties Limited | Real estate | 2020 |
| TAJ Marden Ltd | Hospitality | 2022 |