| Digital ARM Limited | Administrative & support | 2013 |
| Digitaldaves Ltd | Information & communication | 2024 |
| Dignified Life Limited | Other services | 2025 |
| Distributed Intelligence Consultants International Limited | Extraterritorial | 1986 |
| Distributed Intelligence Limited | Extraterritorial | 2006 |
| Distributed Intelligence Systems International Limited | Extraterritorial | 2010 |
| Distributed Intelligence Systems Limited | Extraterritorial | 1988 |
| Diverse Spirits Ltd | Wholesale & retail | 2020 |
| DJK Plumbing and Heating Limited | Construction | 2022 |
| DJP Finishes Limited | Construction | 2011 |
| DMA Stairlifts Limited | Wholesale & retail | 1991 |
| Dolan Properties Limited | Real estate | 2026 |
| Doogle Limited | Information & communication | 2006 |
| Dooo Ltd | Information & communication | 2022 |
| Dormakaba UK Holding Limited | Manufacturing | 1966 |
| Dormakaba UK Limited | Construction | 1978 |
| Down Farm Ltd | Hospitality | 2021 |
| Drayton Holdings Limited | Other services | 2015 |
| Driftshore Cottages Limited | Real estate | 2019 |
| Drscott Dentistry Limited | Health & social care | 2019 |
| DS Training (SW) Ltd | Administrative & support | 2003 |
| Duck & Dive Limited | Professional & scientific | 1999 |
| Ducks Ditty Cafe/Bar Limited | Hospitality | 2025 |
| Dumnonii Ltd | Hospitality | 2024 |
| Duryard Properties Limited | Wholesale & retail | 2019 |
| Duvale Priory Limited | Hospitality | 2020 |
| E M Heywood Limited | Agriculture & fishing | 2025 |
| E Ryder Property Ltd | Real estate | 2020 |
| Earlsmann Lighting Limited | Manufacturing | 2010 |
| Earlsmann Limited | Wholesale & retail | 2006 |
| Earth Minutes Education CIC | Education | 2026 |
| East Devon Tractor Machinery and Engine Club Limited | Other services | 1997 |
| East Ford Farm Management Company Limited | Households | 2024 |
| Easy Living Care Limited | Health & social care | 2014 |
| Easydig South West Limited | Construction | 2007 |
| EBG Services Limited | Administrative & support | 2016 |
| Ecosphere Energy Ltd | Construction | 2022 |
| Ecovale SW Limited | Construction | 2011 |
| Eddie's Padel Ltd | Wholesale & retail | 2026 |
| Edward Dean Limited | Administrative & support | 2022 |
| Edwards Plumbing Services Ltd | Construction | 2015 |
| Edwards Portfolio Holdings Ltd | Information & communication | 2018 |
| Eeline UK Limited | Extraterritorial | 2001 |
| Eeltex Limited | Manufacturing | 2013 |
| Elby Communications Ltd | Manufacturing | 2024 |
| Elder Accounting Solutions Limited | Professional & scientific | 2026 |
| Element Fabrication Limited | Manufacturing | 2025 |
| Elephant Valeting & Detailing Ltd | Administrative & support | 2021 |
| Elgar Development Ltd | Real estate | 2025 |
| Elgar Group Ltd | Administrative & support | 2019 |
| Elgar Nutrition Ltd | Health & social care | 2020 |
| Ellamwalker Accountants Ltd | Professional & scientific | 2021 |
| Ellamwalker Consultants Ltd | Professional & scientific | 2021 |
| Ellamwalker Holdings Ltd | Professional & scientific | 2021 |
| Ellamwalker Limited | Professional & scientific | 2014 |
| Ellamwalker Renewables Ltd | Professional & scientific | 2022 |
| Ellaspire Limited | Professional & scientific | 2013 |
| Ellie’S Sports and Massage Therapy Ltd | Health & social care | 2025 |
| Elmar Puzzles Ltd | Wholesale & retail | 2017 |
| Elsie’S Energy Limited | Financial services | 2019 |
| EM Agriton Limited | Wholesale & retail | 2004 |
| EM Macfarlane Property Group Ltd | Real estate | 2026 |
| Ember Projects Ltd | Professional & scientific | 2024 |
| Emerging Intersections Investments UK Limited | Financial services | 2014 |
| Emma Louise Holistic Therapy Ltd | Health & social care | 2026 |
| Emmanuel Mews Residents Company Limited | Administrative & support | 2003 |
| Empathiq Consulting Ltd | Professional & scientific | 2021 |
| EMT Consulting Ltd | Professional & scientific | 2023 |
| Enemix Group Limited | Administrative & support | 2024 |
| Enemix Limited | Administrative & support | 2024 |
| Engineering Supplies OIL & GAS Limited | Mining & quarrying | 2018 |
| Enhance Interiors SW Ltd | Construction | 2024 |
| Enjoyacake Ltd | Hospitality | 2026 |
| EOP Holdings Ltd | Financial services | 2021 |
| EPJ Management Co Limited | Real estate | 2025 |
| Equestrian Games UK Ltd | Arts & recreation | 2021 |
| Equilibrium Energy Storage Limited | Professional & scientific | 2023 |
| Equilibrium Jewellery Ltd | Wholesale & retail | 2013 |
| Equipment Finance SW Ltd | Financial services | 2024 |
| Equishare Limited | Real estate | 2025 |
| Erthical Ltd | Information & communication | 2021 |
| ES07 Limited | Arts & recreation | 2026 |
| Essebeare Farming LLP | | 2015 |
| Essential VA Ltd | Professional & scientific | 2019 |
| Estrel Planning Ltd | Administrative & support | 2022 |
| Estrel Property Partners Ltd | Households | 2023 |
| Estuary View (Appledore) Management Company Ltd | Households | 2021 |
| Ethmar Court Management Company Limited | Households | 2016 |
| Euan Hankey Motor Sport Limited | Arts & recreation | 2005 |
| Euro Buys Ltd | Hospitality | 2025 |
| Evergreen Regulatory Limited | Administrative & support | 2025 |
| EVO Brands Ltd | Wholesale & retail | 2023 |
| EVO Hospitality Limited | Hospitality | 2023 |
| EVO Marketing Ltd | Wholesale & retail | 2025 |
| EVO Property Investments Limited | Real estate | 2012 |
| Ewsb Waverley Limited | Real estate | 2026 |
| EXE & WHY Ltd | Information & communication | 2025 |
| EXE 11 Ltd | Real estate | 2014 |
| EXE AXE Projects Limited | Construction | 2005 |
| EXE Construction Ltd | Construction | 2018 |