| Ruloma (UK) Limited | Health & social care | 2010 |
| Runathon Limited | Extraterritorial | 2021 |
| S R Alam Limited | Financial services | 2020 |
| S.S.A Training Academy Ltd | Other services | 2025 |
| S1 Chauffeurs Ltd | Transport & logistics | 2023 |
| S6 Digital UK Ltd | Wholesale & retail | 2024 |
| S6 Gym Ltd | Arts & recreation | 2018 |
| S6 Physiques Ltd | Health & social care | 2020 |
| Safe Networks Ltd | Information & communication | 2018 |
| Safeway Shopfitters & Window Glazing Ltd | Construction | 2022 |
| Sagar Window Cleaning Ltd | Administrative & support | 2022 |
| Sahol Limited | Other services | 2017 |
| Sales Methodology Hub Limited | Wholesale & retail | 2025 |
| Salocin Trans Limited | Transport & logistics | 2017 |
| Sandy B Estates Ltd | Real estate | 2026 |
| SAO Transport Ltd | Transport & logistics | 2026 |
| Saqaim Ltd | Wholesale & retail | 2017 |
| Sasity Services Ltd | Manufacturing | 2021 |
| Sass & WAX Co Ltd | Wholesale & retail | 2024 |
| Scaff MAN Products Ltd | Manufacturing | 2024 |
| SCI Health & Safety Ltd. | Professional & scientific | 2017 |
| Sciron Limited | Administrative & support | 2018 |
| Scott B Sullivan Associates Ltd | Professional & scientific | 2015 |
| SD Collaboration Ltd | Public administration | 2025 |
| SD Groundworks 2023 Ltd | Construction | 2023 |
| SEBILICUFLO1983 Ltd | Transport & logistics | 2020 |
| Secretarial Law Services Ltd | Professional & scientific | 2025 |
| Securex Services Limited | Administrative & support | 2024 |
| Sedynam Ltd | Information & communication | 2022 |
| Selby Inc Ltd | Professional & scientific | 2019 |
| Seltanio Limited | Administrative & support | 2019 |
| Semipe Care Services Limited | Health & social care | 2011 |
| Sensible Scaffolding Ltd | Construction | 2022 |
| Serenlivingcare Ltd | Health & social care | 2026 |
| Seth's Supermarket Ltd | Wholesale & retail | 2014 |
| SFS Drylining Ltd | Construction | 2024 |
| Shah Muhammad Property Services Ltd | Real estate | 2021 |
| Shahidul Ltd | Wholesale & retail | 2024 |
| Shak Smith Aesthetics Ltd | Health & social care | 2022 |
| Shamsia Global Limited | Wholesale & retail | 2026 |
| Shane Pizzey Services Ltd | Manufacturing | 2025 |
| Shaw & Aaron Ltd | Health & social care | 2022 |
| Shefa Health and Wellbeing Ltd | Health & social care | 2025 |
| Shein Europe Ltd | Wholesale & retail | 2025 |
| Shelby GLN Ltd | Transport & logistics | 2024 |
| Shells Healthcare Limited | Public administration | 2022 |
| Shepherd's Way Enterprises Limited | Health & social care | 2004 |
| Shinksivaile Ltd | Professional & scientific | 2026 |
| Shoky London Limited | Transport & logistics | 2020 |
| Sholam Consulting Services Limited | Professional & scientific | 2012 |
| Sigma Double Glazing Limited | Construction | 2025 |
| Signature Contractors Ltd | Construction | 2015 |
| Silver Lining Ehcp and Send Consultancy CIC | Education | 2021 |
| Silvertek Limited | Other services | 2017 |
| Simicare Services Limited | Health & social care | 2015 |
| Simply Pristine Ltd | Administrative & support | 2023 |
| SIT Interiors Ltd | Construction | 2017 |
| Skiba ENG Limited | Construction | 2016 |
| Skiba Support Services Ltd | Wholesale & retail | 2015 |
| Sky Dreams Limited | Other services | 2025 |
| Skylineuk Ltd | Transport & logistics | 2020 |
| Skywitness.Space Ltd | Information & communication | 2025 |
| SL Motorcycle Training Limited | Education | 2022 |
| SLC Management Group Ltd | Administrative & support | 2025 |
| SLC Stan Limited | Wholesale & retail | 2024 |
| Smart Business Resilience Ltd | Professional & scientific | 2021 |
| Smart Call Plumbing and Heating Ltd | Construction | 2015 |
| Smart Flame Ltd | Real estate | 2017 |
| Smart Serv Ltd | Hospitality | 2016 |
| Smart Step Homes Ltd | Real estate | 2020 |
| Smart Wear Clothing Limited | Wholesale & retail | 2015 |
| Smartlake Ltd | Hospitality | 2020 |
| Smartview Care Solutions Ltd | Hospitality | 2019 |
| SME Tax Tech Business Development Ltd | Professional & scientific | 2013 |
| SMK (Tilbury) Ltd | Wholesale & retail | 2021 |
| SMR Logistics Limited | Transport & logistics | 2019 |
| SMR Wilkinson Ltd | Construction | 2018 |
| Soaring Tribe Limited | Health & social care | 2022 |
| Soft Curls Limited | Other services | 2017 |
| Sohrabi Motors Ltd | Wholesale & retail | 2013 |
| Sole Vista Podiatry Limited | Health & social care | 2025 |
| Solid Plumb Ltd | Construction | 2026 |
| Solid Plumb Ltd Ltd | Construction | 2026 |
| Sopej Ltd | Health & social care | 2025 |
| Sophie Couriers Limited | Transport & logistics | 2018 |
| Sourceli Ltd | Information & communication | 2025 |
| Southpark Glazing Limited | Construction | 2022 |
| Sovereign Records Limited | Arts & recreation | 2021 |
| Sovereign Songs Limited | Information & communication | 2021 |
| Sovico Limited | Health & social care | 2020 |
| Spac Interiors Ltd | Construction | 2018 |
| Space Jump Ltd | Health & social care | 2019 |
| Spark D' Electrical Ltd | Construction | 2020 |
| Sparkclean Ltd | Administrative & support | 2020 |
| Speed 233 Ltd | Transport & logistics | 2022 |
| SPORTING4SCHOOLS RN Ltd | Education | 2025 |
| SRH Cons Limited | Construction | 2026 |
| SSK Accident Repair Solutions Ltd | Wholesale & retail | 2020 |
| SSM Network Ltd | Other services | 2017 |
| ST Chads Convenience Limited | Wholesale & retail | 2019 |