| Schumann Property Limited | Real estate | 2013 |
| Sculpted Aesthetics Ltd | Other services | 2024 |
| Sea Spice 227 Ltd | Hospitality | 2024 |
| Sector Property Ltd | Real estate | 2021 |
| Sedulity Energy Ltd | Administrative & support | 2020 |
| SEI Electrical Limited | Manufacturing | 2021 |
| Senrab Letting Services Limited | Real estate | 2013 |
| Sense Digital Ltd | Professional & scientific | 2019 |
| Sentry Health Ltd | Wholesale & retail | 2018 |
| SHABBY2CHIC Trading Limited | Wholesale & retail | 2013 |
| Sharky Rentals Ltd. | Real estate | 2023 |
| Sharples Canine Club Ltd | Other services | 2025 |
| Shaw Trade Global Ltd | Wholesale & retail | 2021 |
| Shaw's Plumbing and Heating NW Limited | Construction | 2023 |
| Shed Beer (Bars) Limited | Hospitality | 2022 |
| Shires Modern Living Limited | Real estate | 2022 |
| Shop Utilities Ltd | Extraterritorial | 2021 |
| Shore Point Limited | Households | 1973 |
| Shvitz Limited | Health & social care | 2024 |
| SID Hill Transport Ltd | Transport & logistics | 2020 |
| Sienna 31 Limited | Hospitality | 2025 |
| Simpkins Lambert Ltd | Wholesale & retail | 2025 |
| Sinful Giveaways Ltd | Wholesale & retail | 2022 |
| SIP Installations Ltd | Construction | 2024 |
| SIX Eves Limited | Real estate | 2006 |
| Skin TAG Solutions Ltd | Health & social care | 2025 |
| SKL 16888 Ltd | Hospitality | 2026 |
| Skyline Engineering Services Limited | Construction | 2024 |
| SMA Property Management Ltd | Real estate | 2024 |
| Smart Switch Utilities Limited | Administrative & support | 2025 |
| Smart Tech Security Ltd | Administrative & support | 2017 |
| SMB Waste & Removals Limited | Transport & logistics | 2025 |
| Snibson & Steele Ltd | Hospitality | 2024 |
| Solaire Shadings Limited | Manufacturing | 2021 |
| Solely Electrical Ltd | Construction | 2012 |
| Soloneer Ltd | Information & communication | 2012 |
| Soma Therapies International Ltd | Other services | 2010 |
| Soma Therapies Ltd | Other services | 2003 |
| Sonexsys Ltd | Professional & scientific | 2026 |
| Sorrel Enterprises Limited | Wholesale & retail | 2014 |
| Sorrel Investments Ltd | Real estate | 2020 |
| Souter Properties Limited | Real estate | 2017 |
| South Lytham RD Management Ltd | Real estate | 2026 |
| Spoonii Ltd | Manufacturing | 2025 |
| Spraycoatnw Ltd | Construction | 2025 |
| Sprinkles Express Limited | Hospitality | 2019 |
| SR Properties NW Limited | Households | 2018 |
| Srprigging Ltd | Information & communication | 2024 |
| SS Synergy Private Limited | Other services | 2013 |
| Staffieri Estates Ltd | Real estate | 2017 |
| Stage Ready Training Ltd | Arts & recreation | 2026 |
| Stamos Enterprise Investments Ltd | Professional & scientific | 2022 |
| Standard Machine Co.Limited | Real estate | 1938 |
| Stargirl Services Limited | Wholesale & retail | 2004 |
| Stay Lancaster Ltd | Real estate | 2021 |
| Staycation by Unique Ltd | Hospitality | 2026 |
| Steadfast Exhaust Distributors Limited | Real estate | 1979 |
| Stembridge IT Ltd | Information & communication | 2021 |
| Stephen Cumming Ltd | Transport & logistics | 2023 |
| Sterling Property Capital Limited | Construction | 2017 |
| Steve Farmer Joiner & Builders Ltd | Construction | 2020 |
| Stobsy Ltd | Professional & scientific | 2021 |
| Stonecraft of Lancashire Ltd | Professional & scientific | 2014 |
| Stratton Property Management Limited | Real estate | 2014 |
| Streamline Business Support Ltd | Professional & scientific | 2017 |
| Stripseal Flooring Limited | Other services | 2000 |
| Strong Homes Limited | Real estate | 2018 |
| Studio 3531 Ltd | Professional & scientific | 2023 |
| Style Amusements Limited | Hospitality | 2013 |
| Style Barbers (NW) Ltd | Other services | 2025 |
| Style Carpets Limited | Wholesale & retail | 1993 |
| Style Properties (NW) Limited | Real estate | 2024 |
| Success for Business Ltd | Professional & scientific | 2011 |
| Success in Property Ltd | Extraterritorial | 2022 |
| Sudi BB Ltd | Wholesale & retail | 2021 |
| Sudi ND Ltd | Wholesale & retail | 2024 |
| Sudi Taphouse Ltd | Wholesale & retail | 2025 |
| Sudi VR Ltd | Wholesale & retail | 2023 |
| Sunshine Analysis Solutions Ltd | Professional & scientific | 2019 |
| Sunshine for the Soul Ltd | Other services | 2020 |
| Supreme Horse Transport Ltd | Transport & logistics | 2022 |
| Surecon Limited | Construction | 2017 |
| Surpass With Sarah Limited | Health & social care | 2019 |
| SW Insulation Ltd | Construction | 2018 |
| SWA Project Consulting Limited | Information & communication | 2024 |
| Swift Holdings London Limited | Health & social care | 2010 |
| Switch 4 Business Ltd | Energy | 2025 |
| Sympatic Global Limited | Financial services | 2017 |
| T and T Leisure Limited | Other services | 2017 |
| T&M Utilities Ltd | Construction | 2015 |
| T. Coxon (Landscapes & Maintenance) Limited | Administrative & support | 2011 |
| Taelisee Pizza Ltd | Hospitality | 2025 |
| Tails of Hurstead Ltd | Other services | 2025 |
| Tamara Samuels Property Ltd | Real estate | 2024 |
| Tami Trading Ltd | Wholesale & retail | 2018 |
| TAN Northwest Limited | Other services | 2026 |
| Tarnway Services (NW) Limited | Construction | 2021 |
| Taxi Trucks Limited | Transport & logistics | 1989 |
| TD Clarke Limited | Hospitality | 2022 |
| Teale Assets Limited | Financial services | 2020 |