| Sjh-Designs Ltd | Professional & scientific | 2023 |
| SJM Estates Ltd | Professional & scientific | 2007 |
| SJW Accounts LLP | | 2024 |
| SK Education Ltd | Education | 2014 |
| Skilcom Limited | Manufacturing | 1998 |
| Skydwell AMA Ltd | Real estate | 2023 |
| Skyncare Limited | Wholesale & retail | 2015 |
| Slanting Hill Ltd | Information & communication | 2010 |
| Slanting House Limited | Real estate | 2016 |
| SLH Nails Ltd | Other services | 2008 |
| Small Scale Commercial Beekeeping UK Limited | Other services | 2025 |
| Smart Blinds & Shutters Limited | Wholesale & retail | 2009 |
| Smarter Cleaning (GB) Limited | Administrative & support | 2008 |
| Smith and INK Limited | Other services | 2015 |
| Smith Engineering & Design Ltd | Professional & scientific | 2025 |
| Smyth Consultancy Services Limited | Professional & scientific | 2009 |
| Snetaj Limited | Information & communication | 2015 |
| Snowwing Airside Services Ltd | Agriculture & fishing | 2023 |
| Sokal Labs Ltd | Information & communication | 2026 |
| Solarfarmuk Ltd | Professional & scientific | 2025 |
| Solent Original Walks CIC | Administrative & support | 2025 |
| Solidus Consulting Ltd | Professional & scientific | 2019 |
| Solitera Ltd | Information & communication | 2018 |
| SOM Properties Ltd | Real estate | 2021 |
| Songhai Properties Limited | Real estate | 2023 |
| Sonic IT Limited | Information & communication | 2019 |
| Sophie Power Recruits Limited | Administrative & support | 2019 |
| SOUL222 Ltd | Wholesale & retail | 2023 |
| South Central Event Solutions Ltd | Arts & recreation | 2018 |
| South East Plastering & Construction Ltd | Construction | 2024 |
| Spaa Properties Ltd | Real estate | 2019 |
| Spaceroc Ltd | Information & communication | 2018 |
| Spain Safe Buy Ltd | Real estate | 2026 |
| Sparks Motor Company Limited | Manufacturing | 2022 |
| SPB Stoneworks Ltd | Other services | 2011 |
| SPD Groundworks & Construction Ltd | Construction | 2024 |
| Spire Strategies Ltd | Professional & scientific | 2024 |
| Splittic Technologies Ltd | Information & communication | 2025 |
| SPO Solutions Ltd | Construction | 2026 |
| Sporting Classic Motors Limited | Wholesale & retail | 2007 |
| Spot 16 Medical Ltd | Health & social care | 2024 |
| Spotteddogventures Ltd | Hospitality | 2026 |
| Srampro (Finance) Limited | Extraterritorial | 2007 |
| ST Skyline Properties Ltd | Real estate | 2023 |
| ST. Thomas Court (Management) Limited | Real estate | 1986 |
| ST. Thomas Court (Phase 1) Residents Company Limited | Households | 2000 |
| Stacatruc Holdings Limited | Wholesale & retail | 2019 |
| Stacatruc Limited | Wholesale & retail | 2009 |
| Stacatruc Materials Handling Ltd | Wholesale & retail | 2025 |
| Staffordshire Newspapers Ltd. | Information & communication | 1916 |
| Standish Consulting Ltd | Information & communication | 2006 |
| Stanley and Thomas Boatbuilders Limited | Manufacturing | 2018 |
| Stanton IT Solutions Limited | Information & communication | 2017 |
| Starlight Xpress Limited | Manufacturing | 1966 |
| Station Kebab & Breakfast Ltd | Hospitality | 2025 |
| Stay on Key Ltd | Health & social care | 2017 |
| Steel Strathpine Limited | Financial services | 2025 |
| Steelfoot Ltd | Wholesale & retail | 2015 |
| Stelzer Productions Limited | Other services | 2011 |
| Steven George Construction Ltd | Construction | 2024 |
| Stewart Walker Limited | Wholesale & retail | 2000 |
| Stingray Bidco Limited | Financial services | 2023 |
| Stingray Midco Limited | Financial services | 2023 |
| Stockland Ltd | Professional & scientific | 2024 |
| Stone Craft Driveways and Patios Ltd | Administrative & support | 2026 |
| Straightforward Financial and Property Consultants Limited | Financial services | 2014 |
| Strattons Farms LLP | | 2001 |
| Stride Living Ltd | Health & social care | 2026 |
| Stroud Innovations Limited | Manufacturing | 2013 |
| Stuart Michael Associates Limited | Professional & scientific | 1999 |
| Stuart Shepherd Law Ltd | Professional & scientific | 2018 |
| Studio Bijou Ltd | Arts & recreation | 2021 |
| Studio Innate Ltd | Professional & scientific | 2016 |
| Style of Beyond Ltd | Wholesale & retail | 2013 |
| Styling Products UK Ltd | Wholesale & retail | 2015 |
| Suay (International) Ltd | Manufacturing | 2018 |
| Subifi Limited | Administrative & support | 2024 |
| Subsource Consulting Limited | Construction | 2011 |
| Sudum Ltd | Transport & logistics | 2016 |
| SUE Perry Mindset Coaching Ltd | Health & social care | 2023 |
| Sue's Bookkeeping & Accountancy Ltd | Professional & scientific | 2022 |
| Suite Nine Productions Limited | Information & communication | 2016 |
| Suitstack Limited | Agriculture & fishing | 1981 |
| Sullistays Limited | Households | 2024 |
| Summit Building Group Ltd | Construction | 2022 |
| Summit Electrical (South) Ltd | Construction | 2025 |
| Sund & Cheema Ltd | Information & communication | 2012 |
| Sundays Studio Ltd | Wholesale & retail | 2023 |
| Sunley Wealth Management Ltd | Financial services | 2014 |
| Superbowl UK Aldershot Limited | Arts & recreation | 2023 |
| Superbowl UK Barnsley Limited | Arts & recreation | 2016 |
| Superbowl UK Basingstoke Limited | Arts & recreation | 2024 |
| Superbowl UK Grimsby Limited | Arts & recreation | 2026 |
| Superbowl UK Hull Limited | Arts & recreation | 2014 |
| Superbowl UK Ipswich Limited | Arts & recreation | 2016 |
| Superbowl UK Limited | Extraterritorial | 2015 |
| Superbowl UK Macclesfield Limited | Arts & recreation | 2014 |
| Superbowl UK Merthyr Limited | Arts & recreation | 2015 |
| Superbowl UK Norwich Limited | Arts & recreation | 2017 |
| Superbowl UK ST Helens Limited | Arts & recreation | 2016 |