| Project X Ltd | Information & communication | 2014 |
| Property Repair Systems Limited | Wholesale & retail | 2007 |
| Protocol Management (UK) Limited | Hospitality | 1999 |
| PSB Garages Limited | Administrative & support | 1997 |
| PTO Transitions Ltd | Education | 2014 |
| Puccini's Limited | Real estate | 2009 |
| Pukka Sheds Ltd | Other services | 2019 |
| Pumpleback Limited | Professional & scientific | 2024 |
| PVC Pipe World Ltd | Manufacturing | 2005 |
| Q a South-West Limited | Administrative & support | 2010 |
| Qodus Ltd | Wholesale & retail | 2021 |
| Quarrystone Holdings Ltd | Financial services | 2026 |
| Quaymoto Limited | Wholesale & retail | 2003 |
| Quintet Construction Management Ltd | Construction | 2020 |
| R K Drew and Sons Limited | Construction | 2003 |
| R.A.S. Accounting Ltd | Professional & scientific | 2019 |
| R.D. Edwards Limited | Construction | 2003 |
| RAC Construction SW Limited | Construction | 2021 |
| Rachel Palmer Multimedia Ltd | Professional & scientific | 2023 |
| Rainbow Whale Ltd | Wholesale & retail | 2020 |
| Rare and Antique Books Limited | Wholesale & retail | 2021 |
| RCW Fishing Limited | Administrative & support | 2016 |
| Red Rock Commercial Holdings Limited | Real estate | 2020 |
| Red Rock Commercial Lettings Limited | Real estate | 2020 |
| Red Rock Landscaping Limited | Administrative & support | 2022 |
| Red Rock Plant and Groundworks Ltd | Construction | 2020 |
| Red Tiles Management Co. Limited | Households | 2001 |
| Redcliffs Holidays Ltd | Hospitality | 2019 |
| Reeve Surveying Limited | Professional & scientific | 2018 |
| Renew Party Limited | Administrative & support | 2017 |
| Resilient Parenting CIC | Health & social care | 2024 |
| Richmond House Management Company (Shaldon) Limited | Real estate | 2002 |
| Right Lines Solutions Limited | Information & communication | 2014 |
| Right Staff Recruitment (South West) Limited | Administrative & support | 2020 |
| Right Way Scaffolding (Devon) Limited | Construction | 2025 |
| Risk and Regulation Consulting Limited | Financial services | 2008 |
| Risk View Solutions Ltd | Information & communication | 2024 |
| River Teign Rowing Club Limited | Arts & recreation | 1999 |
| Rivercoombe Building Company Limited | Construction | 1993 |
| RK ELC Ltd | Construction | 2024 |
| RO Devon Plumbing Limited | Construction | 2008 |
| Roach Planning and Environment Limited | Administrative & support | 2017 |
| Roam Home Ltd | Wholesale & retail | 2025 |
| Robin Catering Equipment Limited | Wholesale & retail | 1974 |
| Rockaway Beach Ltd | Professional & scientific | 2020 |
| Rocklands Enterprise Ltd | Professional & scientific | 2023 |
| Rosalie Holdings Ltd | Financial services | 2023 |
| Rudall Limited | Real estate | 2018 |
| S & J Carpentry Southwest Ltd | Construction | 2017 |
| S & J G Property Ltd | Real estate | 2025 |
| S & K Plastering and Rendering Specialists Limited | Construction | 2024 |
| S Kelly Social Work Limited | Health & social care | 2010 |
| S.A Property Investments (SW) Ltd | Construction | 2016 |
| Saas Marketing Services Ltd | Professional & scientific | 2025 |
| Safeguarding for Excellence Limited | Professional & scientific | 2011 |
| Saltwater Marine Ltd | Construction | 2023 |
| Salty Dog Kiosks Limited | Hospitality | 2017 |
| Sana Curry Limited | Hospitality | 2025 |
| Sandfield Travel Ltd | Administrative & support | 2014 |
| Sapla Limited | Hospitality | 2017 |
| Sarcen Consulting Limited | Information & communication | 2017 |
| Sarcen Group Limited | Information & communication | 2017 |
| SB83-SOLUTIONS Ltd | Construction | 2020 |
| Scrumptious Events & Transport Management Consultancy Ltd | Professional & scientific | 2023 |
| SDM Plumbing & Heating Ltd | Construction | 2014 |
| Sea Breeze Holdings Limited | Real estate | 2018 |
| Sea Change Marketing Limited | Administrative & support | 2012 |
| Seabreeze (Teignmouth) Management Limited | Real estate | 2020 |
| Seafood Australia Ltd | Wholesale & retail | 2020 |
| Seapoint House (Teignmouth) Management Company Limited | Households | 2003 |
| Seasports Southwest Limited | Arts & recreation | 2007 |
| Sennen Court Management Company Limited | Households | 2017 |
| Seventh Tree Investment Limited | Real estate | 2017 |
| Shaldon Associates Limited | Hospitality | 2004 |
| Shaldon Coffee Company Limited | Hospitality | 2025 |
| Shaldon Holidays Ltd | Hospitality | 2019 |
| Shaldon Medico-Legal Limited | Health & social care | 2018 |
| Shaldon Quay Company Limited | Construction | 2008 |
| Shaldon Services Community Interest Company | Wholesale & retail | 2022 |
| Shaldon Water Carnival | Other services | 2012 |
| Shaldon Wildlife Trust Limited | Arts & recreation | 1985 |
| Shape UP Sounds Ltd | Information & communication | 2025 |
| Sherlock Homes South West Limited | Construction | 2024 |
| Shore Link Ltd | Administrative & support | 2024 |
| Short Fuse Creative Ltd | Information & communication | 2012 |
| Showdale Limited | Construction | 2004 |
| Simon Turl & Sons Moorings Ltd | Other services | 2024 |
| Simply Church, Teignmouth | Other services | 2009 |
| Simply Ones and Zeros Limited | Information & communication | 2019 |
| Site Staffing Solutions Limited | Administrative & support | 2024 |
| SJH Properties Limited | Real estate | 1997 |
| SJM South West Limited | Construction | 2014 |
| Sky Tech Images Limited | Construction | 2023 |
| Skyline Competitions Limited | Arts & recreation | 2024 |
| Skypro Productions Limited | Information & communication | 2008 |
| SLA Tax Limited | Professional & scientific | 2008 |
| Smart Communications Limited | Manufacturing | 1988 |
| Smarter Financial Advice Limited | Professional & scientific | 2020 |
| Smarter Operations Limited | Professional & scientific | 2016 |
| Smirthwaite Properties Limited | Real estate | 1996 |