| TWC Analysis Ltd | Professional & scientific | 2021 |
| TWC Cleaning Contractors Ltd | Administrative & support | 2005 |
| Twenty Five 7 Ltd | Professional & scientific | 2017 |
| Twin UP Medics Ltd | Health & social care | 2024 |
| Twin UP Sports Ltd | Wholesale & retail | 2024 |
| Two Lyns Ltd | Real estate | 2025 |
| Two Moors Practice Holdings Ltd | Financial services | 2026 |
| Two Trading Ltd | Wholesale & retail | 2016 |
| TXT Consultants Ltd | Professional & scientific | 2021 |
| TY Berllan Ltd | Hospitality | 2025 |
| Ubalance Limited | Wholesale & retail | 2016 |
| Ubique Property Services Ltd | Households | 2025 |
| Ubique Renewables Ltd | Professional & scientific | 2026 |
| Udall Renovations Limited | Construction | 2023 |
| UDC Limited | Health & social care | 2016 |
| Uffculme Court Management Company Limited | Households | 1984 |
| UK Aviation Sales Ltd | Administrative & support | 2010 |
| UK Care Hub Ltd | Administrative & support | 2024 |
| UK Drone Surveys Ltd | Professional & scientific | 2024 |
| UK Helisales Limited | Professional & scientific | 2001 |
| UK Hydrogen Ltd | Energy | 2020 |
| UK Nursing Ltd | Professional & scientific | 2007 |
| UK Surfacing Group Ltd | Administrative & support | 2013 |
| Ukadian Interiors Limited | Manufacturing | 1981 |
| Ukhsi Limited | Education | 2010 |
| Ultra Project Management Services Ltd | Information & communication | 2020 |
| Ultra Vires Ltd | Construction | 2025 |
| UM Autonomous Systems Limited | Other services | 2021 |
| Umut Catering Limited | Administrative & support | 2013 |
| Under One Roof Welfare Limited | Extraterritorial | 2016 |
| Underwood Homes Limited | Real estate | 2021 |
| Unicorn Saddlery Limited | Wholesale & retail | 2006 |
| Union Bathrooms Limited | Wholesale & retail | 2020 |
| Unique Pearl Boutique Ltd | Manufacturing | 2017 |
| United Car Company Ltd | Wholesale & retail | 2025 |
| United Reformed Church (South Western Synod) Incorporated(The) | Other services | 1977 |
| United Registrar of Systems (Holdings) Limited | Financial services | 2019 |
| United Registrar of Systems Limited | Other services | 1994 |
| United Registrar of Systems Products Limited | Other services | 2015 |
| Unitnext Residents Management Limited | Real estate | 1988 |
| Unity OH Ltd | Professional & scientific | 2023 |
| Universal Bistro 8 Limited | Hospitality | 2015 |
| Unlock Change Limited | Professional & scientific | 2016 |
| Unlupinar Ltd | Hospitality | 2023 |
| UP Construction and Refurbishment Limited | Real estate | 2016 |
| UP the Smarts Ltd | Extraterritorial | 2023 |
| UP to the Bell Limited | Information & communication | 2024 |
| Upham Construction Limited | Construction | 2024 |
| Uphill Wharf Cafe-Bar Limited | Hospitality | 2017 |
| Upper Pubs Limited | Hospitality | 2025 |
| Upwood Enterprises Limited | Real estate | 2021 |
| Urora Limited | Wholesale & retail | 2021 |
| Ursg Limited | Professional & scientific | 2004 |
| Usafi Healthcare Limited | Health & social care | 2015 |
| Used Subaru Parts Ltd | Manufacturing | 2018 |
| Uvokekes Limited | Real estate | 2023 |
| UX3 Limited | Professional & scientific | 2012 |
| Uxahead Limited | Information & communication | 2023 |
| Uxella Publicity Limited | Information & communication | 2005 |
| Uzvi Services Ltd | Information & communication | 2025 |
| V Amsterdam LLP | | 2018 |
| V Art Engineering Ltd | Construction | 2026 |
| V Hammond Investments Ltd | Financial services | 2026 |
| V K Laundry LLP | | 2012 |
| V L Popham Limited | Other services | 2002 |
| V L Roberts Limited | Financial services | 2023 |
| V-V Edge Ltd | Other services | 2024 |
| V.G., MRS M.M. & M.G. Greenway Limited | Agriculture & fishing | 2003 |
| V.I.M. Services Limited | Other services | 2019 |
| VA VET Services Limited | Professional & scientific | 2016 |
| Vagabond Events Limited | Wholesale & retail | 2026 |
| Valence Construction Limited | Construction | 2011 |
| Vallorcine Asset Management Limited | Real estate | 2021 |
| Van Arnhem Landscapes LLP | | 2010 |
| Van Bitz Limited | Professional & scientific | 1997 |
| Van Boven Advocaten LLP | | 2011 |
| Van DEN Boogaard & Smulders Accountancy LLP | | 2012 |
| Van DER Laan Medical LLP | | 2014 |
| Van DER ZON Management EN Beheer Limited | Professional & scientific | 2009 |
| Van Luijn Holding Ltd. | Professional & scientific | 2009 |
| Van Vloten Reichenbach Schuldink Advocaten LLP | | 2020 |
| Van Weelden Stamrechtbeheer Limited | Professional & scientific | 2010 |
| Vanguard Properties Limited | Real estate | 1972 |
| Vaniers Limited | Manufacturing | 2001 |
| Vanlife CC Ltd | Manufacturing | 2020 |
| Vantage Hill Partners Ltd | Professional & scientific | 1999 |
| Vape-It UK Limited | Wholesale & retail | 2014 |
| Varangian Security and Risk Ltd | Administrative & support | 2025 |
| Varsys Ltd | Professional & scientific | 2022 |
| VB Home and Tech Ltd | Wholesale & retail | 2025 |
| Vcare 786 Ltd | Administrative & support | 2016 |
| VE & JM Sellick Limited | Agriculture & fishing | 2004 |
| Vegan Shack UK Ltd | Hospitality | 2020 |
| Velerique Ltd | Wholesale & retail | 2026 |
| Vellacott Environmental Limited | Real estate | 2024 |
| Vellacott Holdings Limited | Real estate | 2024 |
| Vellacott Launderettes Limited | Other services | 2012 |
| Vellow Holdings Ltd | Real estate | 2021 |
| Veltone Ltd | Manufacturing | 2025 |
| Velvet Dental Centre Limited | Health & social care | 2006 |