| Russet Gold Ltd | Wholesale & retail | 2025 |
| Ruth's SEN DEN Limited | Health & social care | 2025 |
| RW Calculytics Limited | Financial services | 2017 |
| RW Holdings (South West) Limited | Financial services | 2020 |
| RWG Roofing Ltd | Construction | 2019 |
| RXA Logistics Ltd | Transport & logistics | 2025 |
| Ryan White Ltd | Financial services | 2025 |
| Ryans Kegs Limited | Hospitality | 2026 |
| Ryesland Properties Limited | Real estate | 2021 |
| S & JP Developments Ltd | Real estate | 2025 |
| S & JP Investments Limited | Real estate | 2005 |
| S & L Ryall Logistics Ltd | Transport & logistics | 2019 |
| S & N Trade Taunton Ltd | Real estate | 2024 |
| S & R Sinclair Assets Ltd | Professional & scientific | 2021 |
| S & S Mears Limited | Professional & scientific | 1993 |
| S and E Bacon Limited | Agriculture & fishing | 2006 |
| S C Blew Automotive Services Limited | Wholesale & retail | 2018 |
| S C Forecourts Limited | Construction | 2014 |
| S C Lyons Haulage Limited | Transport & logistics | 2014 |
| S Cleal Scaffolding Ltd | Extraterritorial | 2025 |
| S J Edwards Builders Limited | Construction | 2003 |
| S L Haulage Contracting Ltd | Transport & logistics | 2026 |
| S Martin & Sons Building Ltd | Construction | 2016 |
| S N Precision Building Limited | Construction | 2015 |
| S Oaten Limited | Construction | 2003 |
| S P L (Crewkerne) LLP | | 2010 |
| S Parry Holdings Ltd | Financial services | 2022 |
| S Patel Medical Limited | Health & social care | 2020 |
| S Pope Services Limited | Professional & scientific | 2026 |
| S R B Just Fires Ltd | Construction | 2017 |
| S R Keedwell Holdings Limited | Financial services | 2020 |
| S Wellings Plant Hire Ltd | Manufacturing | 2025 |
| S&L Property Group Ltd | Real estate | 2020 |
| S-Wise Ltd | Wholesale & retail | 2023 |
| S. Jones-Richards Ltd | Professional & scientific | 2018 |
| S. Loveridge & Sons Ltd | Wholesale & retail | 2012 |
| S.C Agri Services Ltd | Professional & scientific | 2020 |
| S.G. Property Holdings and Investments Limited | Real estate | 2023 |
| S.J.T.F. Claessen Limited | Professional & scientific | 1995 |
| S.Oaten Properties Limited | Real estate | 2007 |
| S.R Drivers Ltd | Other services | 2020 |
| S.W. Fencing & Landscaping Ltd | Construction | 2017 |
| S.W. Properties (South West) Ltd | Real estate | 2023 |
| S.W. Testing Services Limited | Professional & scientific | 2003 |
| S.W.T. (Sales) Limited | Wholesale & retail | 1977 |
| SA & EJ Kirk and SON Limited | Agriculture & fishing | 2007 |
| SA Barber Taunton Ltd | Other services | 2026 |
| SA Diamond Smile Limited | Health & social care | 2024 |
| SA Electrics Limited | Construction | 2021 |
| Sabatb Limited | Wholesale & retail | 2019 |
| Sabden Brook Ltd | Financial services | 2025 |
| Sabre Edge Limited | Administrative & support | 1995 |
| Sabre Films Limited | Information & communication | 2011 |
| Sacamah Limited | Real estate | 2023 |
| Safarvalo Ltd | Information & communication | 2025 |
| Safe Ideas Ltd | Information & communication | 2013 |
| Safepetz Ltd | Wholesale & retail | 2025 |
| Sage Construct Ltd. | Construction | 2016 |
| SAH Consulting Limited | Wholesale & retail | 2025 |
| Saithane Limited | Real estate | 1978 |
| Salisbury Property Holdings Limited | Real estate | 2017 |
| Sallaha Ltd | Information & communication | 2024 |
| Sallyport Ltd | Real estate | 2006 |
| Salowder Ltd | Real estate | 2024 |
| Salty Film Productions Limited | Information & communication | 2016 |
| Salutis Solutions Limited | Professional & scientific | 2009 |
| SAM Barlow Ltd | Real estate | 2023 |
| Samanntha Limited | Wholesale & retail | 2026 |
| Samantha Louise Accountancy Limited | Professional & scientific | 2023 |
| Sambiggy Group Ltd | Health & social care | 2023 |
| Samjonzi Ltd | Health & social care | 2023 |
| Samra Housing Ltd | Real estate | 2023 |
| Samways Fish Merchants & International Transporters Limited | Wholesale & retail | 2002 |
| Samzaya Ltd | Financial services | 2019 |
| Sancom Services Ltd | Administrative & support | 2016 |
| Sand Street Property Ltd | Real estate | 2025 |
| Sandbridge Limited | Administrative & support | 2012 |
| Sanderson Vets Limited | Professional & scientific | 2021 |
| Sandhill Estate Management Company Limited | Households | 2015 |
| Sandhill Parkland Management Company Limited | Households | 2015 |
| Sandokan Property Holdings Ltd | Real estate | 2026 |
| Sandpits Heating Centre Ltd | Wholesale & retail | 2013 |
| Sandra Production Limited | Health & social care | 2024 |
| Sandstone Origin Limited | Real estate | 2024 |
| Sandwick Developments & Investments Ltd | Real estate | 1979 |
| Sandyhills Farm Limited | Agriculture & fishing | 2022 |
| Sanford Court 2009 Management Company Limited | Households | 2009 |
| Sante Wines Limited | Wholesale & retail | 2013 |
| Sapient Automotive Ltd | Real estate | 2005 |
| Sapientiam Limited | Arts & recreation | 2013 |
| Sapwood Construction Ltd | Construction | 2006 |
| SAR Heating Limited | Construction | 2021 |
| Sara L COX Ltd | Arts & recreation | 2024 |
| Sarah Celebrant Ltd | Other services | 2023 |
| Sarah Hodge Limited Liability Partnership | | 2010 |
| Sarah Moore Dental & Facial Limited | Health & social care | 2018 |
| Sarah Rundell Limited | Information & communication | 2021 |
| Sarah's Posse LLP | | 2009 |
| Saranda Medical Ltd | Health & social care | 2018 |
| Sarum Farm Vets Limited | Professional & scientific | 2024 |