| S G H Equipment Limited | Manufacturing | 2005 |
| S Holland Consultancy Limited | Professional & scientific | 2015 |
| S L Auctions Limited | Other services | 2023 |
| S Porter Associates Ltd | Wholesale & retail | 2013 |
| S S Dosanjh Limited | Real estate | 2017 |
| S.A.M. Engineering (Northwest) Limited | Manufacturing | 2008 |
| Saints of Tarporley Services Limited | Real estate | 2005 |
| Salesminds Ltd | Professional & scientific | 2024 |
| Salesworxs Limited | Professional & scientific | 2016 |
| Salon 32 Limited | Other services | 2025 |
| SAM Rudd Textiles Ltd | Wholesale & retail | 2025 |
| Sambek Limited | Financial services | 2018 |
| Sanare Spa Ltd | Other services | 2025 |
| Sandon Gate (Haydock) Residents Management Company Limited | Households | 2026 |
| Sandpiper Grange Whitby Management Company Limited | Households | 2026 |
| Sandstone Digital Partners Ltd | Information & communication | 2026 |
| Sandstone Limited | Education | 1992 |
| Sandstone Trust | Education | 2012 |
| Sandy Brow Management Company Limited | Households | 2022 |
| Santangeli Limited | Other services | 2012 |
| Sarnfaen Holiday Park LLP | | 2025 |
| Sarnfaen Limited | Hospitality | 2026 |
| Sassi Consultants Limited | Professional & scientific | 2015 |
| SAY IT Write Ltd | Information & communication | 2015 |
| Scala Holdco Ltd. | Administrative & support | 2018 |
| Scape Consulting Services Limited | Information & communication | 2006 |
| Scarlett Limited | Extraterritorial | 2008 |
| Scopecharter Ltd | Information & communication | 2026 |
| Scott Architecture Limited | Professional & scientific | 2012 |
| Seaham Garden Village Residents Management Company Limited | Households | 2024 |
| Seahorse Stud Ltd | Agriculture & fishing | 2022 |
| Sean Pattinson Limited | Manufacturing | 2025 |
| Sedulous Limited | Administrative & support | 2019 |
| Seelogic Limited | Administrative & support | 2004 |
| Selyor Limited | Professional & scientific | 2005 |
| Selyor Properties Ltd | Construction | 2014 |
| Sensoria Limited | Other services | 2014 |
| Sensoria North West Limited | Other services | 2022 |
| Sentinel Investment Capital Limited | Financial services | 2017 |
| Sentinel Investment Group Ltd | Financial services | 2020 |
| Sentinel Private Finance Limited | Financial services | 2020 |
| Sentry Developments Ltd | Professional & scientific | 2014 |
| Serenity by Stacey Leach Ltd | Other services | 2014 |
| Sero Group Limited | Information & communication | 2019 |
| SG Consult Tech Ltd | Administrative & support | 2016 |
| SG Law (UK) Ltd. | Professional & scientific | 2014 |
| SG Law LLP | | 2014 |
| Shaftmoor Estates Limited | Real estate | 1987 |
| Sharp Black Flat White Ltd | Hospitality | 2024 |
| Shays Farm Glamping Limited | Hospitality | 2020 |
| Sherdley Green Residents Management Company Limited | Households | 2023 |
| Shimmy Group Ltd | Information & communication | 2023 |
| Shining Bright Domestic Services Limited | Professional & scientific | 2019 |
| Shire Court Management (Cheshire) Limited | Real estate | 2013 |
| Shortfield Staff Facilities Ltd | Administrative & support | 2025 |
| Shredding UK Limited | Water & waste | 2006 |
| Sight for ALL Ltd | Real estate | 2015 |
| Signature Spaces by Adrian Hollinghurst Ltd | Construction | 2018 |
| Silverne Place Management Company Ltd | Households | 2023 |
| Simfx Ltd | Information & communication | 2020 |
| Sinead Dunne Art Ltd | Education | 2025 |
| Sisserou Restaurant Ltd | Hospitality | 2017 |
| SK2MW Ltd | Wholesale & retail | 2025 |
| Skinphinity Ltd | Health & social care | 2017 |
| Skmw Solutions Ltd | Information & communication | 2020 |
| Skyline Residents Management Company Limited | Households | 2026 |
| Slate Meadow (Bourne END) Management Company Ltd | Households | 2023 |
| SLH Vending Ltd | Wholesale & retail | 2023 |
| SLR FBA Ltd | Wholesale & retail | 2025 |
| SLR Signalling Services Limited | Professional & scientific | 2015 |
| SM Investment (UK) Limited | Administrative & support | 2012 |
| Smart Money Finance Limited | Financial services | 2015 |
| Smart Money Holdings Ltd | Financial services | 2017 |
| Smart Money Limited | Financial services | 2009 |
| Smarterheat Ltd | Construction | 2021 |
| Smith Associates and Holdings Ltd | Transport & logistics | 2020 |
| Smithy Court Clotton Management Company Limited | Households | 2004 |
| Smokermotive Ltd | Hospitality | 2021 |
| Snelsmoor Village Management Company Limited | Households | 2023 |
| Solaire Consulting Limited | Information & communication | 2017 |
| Somerford Gate (Congleton) Residents Management Company Limited | Households | 2021 |
| Soul Hair Ltd | Other services | 2007 |
| South Cheshire Healthcare Limited | Health & social care | 2019 |
| Southern Overseas Ltd | Administrative & support | 2012 |
| Southwaite Properties Ltd | Administrative & support | 2023 |
| Spagyric 3 Limited | Agriculture & fishing | 2014 |
| Sparkling Strawberry 2022 Ltd | Wholesale & retail | 2022 |
| Specialist Vehicle Services (SVS) Ltd | Wholesale & retail | 2019 |
| Spencer Belmont Managememt Ltd | Administrative & support | 2026 |
| Spencers Park Residents Management Company Limited | Households | 2024 |
| Sporting Stars Academy Limited | Education | 2026 |
| Springfield Signalling Limited | Construction | 2024 |
| Spurstow Hall Consultancy Limited | Professional & scientific | 2016 |
| SRC Property Rentals Limited | Real estate | 2025 |
| SRG Electrical Group Ltd | Construction | 2026 |
| ST Ippolyts (Hitchin) Management Company Limited | Households | 2025 |
| ST Johns View Residents Management Company Limited | Households | 2022 |
| ST Lukes RMC Limited | Households | 2024 |
| ST Mary View Management Company Limited | Households | 2024 |
| ST Wilfrid's Place (Litherland) Residents Management Company Limited | Households | 2022 |