| Rbnb | Hospitality | 1994 |
| Re-Emergence Records New Ltd | Wholesale & retail | 2024 |
| Rebecca Holden Consultancy Services Limited | Professional & scientific | 2020 |
| Rebel Roses Limited | Wholesale & retail | 2019 |
| Reef Recycling Ltd | Water & waste | 2014 |
| Reid Constance Ltd | Health & social care | 2019 |
| Reign Leaders Limited | Professional & scientific | 2013 |
| RG Corporate Solutions Limited | Real estate | 2020 |
| Rgaunt Interiors Ltd | Construction | 2024 |
| RH Flooring Solutions (Yorkshire) Limited | Construction | 2024 |
| Richa Energy Consultants Ltd | Professional & scientific | 2017 |
| Richard Rooke Limited | Transport & logistics | 1969 |
| Riley-Smith Hall Trading Limited | Hospitality | 2022 |
| Riverside View (Tadcaster) Management Company Limited | Households | 2026 |
| Riyan Tech Ltd | Information & communication | 2025 |
| RJ International Ltd | Professional & scientific | 2015 |
| RJC Plant Services Limited | Water & waste | 2014 |
| RNC Heritage Limited | Real estate | 2022 |
| Roast Coffee Shop (Tadcaster) Ltd | Hospitality | 2025 |
| Roebuck Productions Limited | Information & communication | 2006 |
| Root Catering and Events Limited | Hospitality | 2024 |
| Root Coaching Limited | Arts & recreation | 2024 |
| ROOT3 Associates Ltd | Professional & scientific | 2007 |
| RS Cottages (Egremont) Ltd | Real estate | 2022 |
| RS Cottages (Seahouses) Ltd | Hospitality | 2022 |
| RS Motor Holdings Limited | Wholesale & retail | 2020 |
| RSC Property Solutions Ltd | Real estate | 2023 |
| RSJ Services Ltd | Professional & scientific | 2005 |
| Rudgate Hall Projects Limited | Real estate | 1998 |
| Rzonca Homes Ltd | Construction | 2019 |
| S & W Estate Planning Limited | Financial services | 2019 |
| S Watson & SON Limited | Construction | 2014 |
| S&Aj Sales Ltd | Water & waste | 2020 |
| S1 Car & Van Ltd | Wholesale & retail | 2017 |
| Safebuild Group Limited | Information & communication | 2026 |
| Safetywise Limited | Professional & scientific | 1998 |
| Saltaire Facilities Management Limited | Real estate | 2004 |
| Salutone Ltd | Transport & logistics | 2021 |
| Sanandre Ltd | Real estate | 2023 |
| Sassypantsthelabel Limited | Wholesale & retail | 2022 |
| SBR BSL ATW Services Ltd | Professional & scientific | 2024 |
| Scallywags Barbershop Ltd | Other services | 2024 |
| Scarthingwell Old Hall Barns Management Committee Limited | Real estate | 2022 |
| Scarthingwell Park Property Management Limited | Households | 2009 |
| Scott Walsh Property Specialists Limited | Professional & scientific | 2025 |
| SE7EN Video Productions Limited | Information & communication | 2014 |
| Sea Chips Ltd | Manufacturing | 2013 |
| Secret Forest Limited | Hospitality | 2012 |
| Sella Products Limited | Wholesale & retail | 2021 |
| Service Sports (Wetherby) EOT Ltd | Financial services | 2024 |
| Serviced Dispense Equipment (Holdings) Limited | Professional & scientific | 2003 |
| Serviced Dispense Equipment Limited | Manufacturing | 2003 |
| Sharon Huffen Accountants Limited | Professional & scientific | 2012 |
| Shawmile Ltd | Professional & scientific | 2002 |
| Sherpas AI Limited | Education | 2026 |
| Shmoo Ltd | Hospitality | 2020 |
| Shortech Consulting Limited | Information & communication | 2021 |
| Showtime Accessories Ltd | Wholesale & retail | 2017 |
| Sibling Residential Limited | Real estate | 2014 |
| Sibling Workspace (Newcastle) Limited | Real estate | 2025 |
| Sibling Workspace Limited | Real estate | 2013 |
| Signagraphics UK Limited | Construction | 2012 |
| Simply Evolve Ltd | Information & communication | 2015 |
| Skelf Frames Limited | Wholesale & retail | 2010 |
| Sketchley Site Clearance Limited | Administrative & support | 2023 |
| SKP Plumbing & Heating Limited | Construction | 2019 |
| Soapstone Associates Limited | Construction | 2009 |
| Soapstone Consulting Limited | Professional & scientific | 2011 |
| Soft Furnishings Direct Limited | Manufacturing | 2019 |
| Solaris Transport Ltd | Wholesale & retail | 2018 |
| Sonali (Tadcaster) Limited | Hospitality | 2017 |
| Sonnetix Limited | Information & communication | 2015 |
| Soteria Security Services Ltd | Administrative & support | 2020 |
| Soul Limited | Professional & scientific | 2023 |
| South Milford Associates Limited | Wholesale & retail | 2008 |
| Sovereign Legal Services Ltd | Administrative & support | 2010 |
| Spanners and Spray Limited | Wholesale & retail | 2015 |
| Specialised Flooring Systems Limited | Construction | 2019 |
| Spectrum Tile Agency Limited | Wholesale & retail | 2021 |
| Spidey Courier Ltd | Transport & logistics | 2019 |
| Sport Yorkshire Limited | Arts & recreation | 2017 |
| Stack Pathway Limited | Information & communication | 2016 |
| Stakemaster Ltd | Arts & recreation | 2025 |
| Stares Holdings Limited | Wholesale & retail | 2025 |
| Startup Sherpas Education Limited | Education | 2021 |
| Steeton Farm | Agriculture & fishing | 1983 |
| Stewart Lawton Limited | Wholesale & retail | 1992 |
| Strathon Holdings Limited | Financial services | 2014 |
| Strawfield Properties Limited | Real estate | 2013 |
| Strecks Limited | Wholesale & retail | 2016 |
| Strettons MOT Station Ltd | Wholesale & retail | 2016 |
| Stuttondale Properties Limited | Hospitality | 2002 |
| Style Movement Ltd | Other services | 2026 |
| Sugaryork Limited | Hospitality | 2025 |
| Superdigital Direct Ltd | Professional & scientific | 2022 |
| Surgeforward Limited | Professional & scientific | 1997 |
| Sustaina GEN Limited | Wholesale & retail | 2024 |
| Swift Accident Management Ltd | Administrative & support | 2025 |
| T W Gaythorpe Ltd | Agriculture & fishing | 2023 |
| T.P. Tate Limited | Arts & recreation | 1978 |