| Emerald Beauty Palace Ltd | Wholesale & retail | 2024 |
| Emerald Damp Specialists Ltd | Construction | 2022 |
| Emerald Hill Asset MGT Ltd | Real estate | 2021 |
| Emerald Prestigious Properties Ltd | Real estate | 2021 |
| Emerald Resilience Ltd | Other services | 2024 |
| Emerald Surveying Ltd Ltd | Construction | 2025 |
| Emeraldam Ltd | Health & social care | 2022 |
| Emergency Assistance Repatriations Ltd | Transport & logistics | 2019 |
| Emergency Security Services (Swindon) Limited | Administrative & support | 1979 |
| Emerging World Leadership Development Limited | Administrative & support | 2004 |
| EMF Real Estate Limited | Hospitality | 2024 |
| Emform Coaching Ltd | Arts & recreation | 2025 |
| Emily EG Cook Ltd | Professional & scientific | 2021 |
| Emily Mustafa Consulting Ltd | Professional & scientific | 2022 |
| Emma Kersey Consulting T/A Proficient - LY Training Ltd | Professional & scientific | 2025 |
| Emma Peck Wealth Management Ltd | Financial services | 2018 |
| Emotorexpert Ltd | Professional & scientific | 2023 |
| EMP 2019 Ltd | Hospitality | 2019 |
| EMP Kitchen Ltd | Hospitality | 2016 |
| Emperor Property Development Limited | Real estate | 2023 |
| Empire Carpentry Limited | Manufacturing | 2013 |
| Empire Loft Conversions Ltd | Construction | 2025 |
| Empire Real Estate Construction Limited | Real estate | 2020 |
| Empire Technology Services Limited | Information & communication | 2023 |
| Employee Services Limited | Administrative & support | 1980 |
| Empo Group Limited | Hospitality | 2024 |
| Emporium Classic Design Ltd | Construction | 2021 |
| Emporium Court Management Company Limited | Real estate | 2020 |
| Empowering Holdings Limited | Financial services | 2024 |
| Empyrean Lettings Limited | Real estate | 2024 |
| Emre Barber Swindon Ltd | Other services | 2025 |
| Emre Cutz Ltd | Other services | 2025 |
| EMS Landscaping Limited | Administrative & support | 2003 |
| Emsai Ltd | Wholesale & retail | 2012 |
| Emsworth Specialist Practice Limited | Health & social care | 2010 |
| Emykelly Ltd | Health & social care | 2014 |
| Enaa Investments Ltd | Construction | 2022 |
| Enablerise Disability Consultants Limited | Other services | 2024 |
| Enchantedin Ltd | Wholesale & retail | 2025 |
| Encourage Consulting Limited | Professional & scientific | 2013 |
| Endeavour Cleaning Services Ltd | Administrative & support | 2013 |
| Enderon Limited | Professional & scientific | 2021 |
| Endless Deals Ltd | Wholesale & retail | 2026 |
| Endo World Limited | Health & social care | 2026 |
| Endsleigh Pension Trustee Limited | Extraterritorial | 2006 |
| Endure Healthy Lifestyle Limited | Wholesale & retail | 2016 |
| Enee Ltd | Information & communication | 2014 |
| Energex Electrical Ltd | Construction | 2021 |
| Energy Development Services Ltd | Education | 2009 |
| Energy Forefront Ltd | Professional & scientific | 2017 |
| ENF Solutions Limited | Professional & scientific | 2017 |
| Engcast Limited | Manufacturing | 2017 |
| English Heritage Limited | Administrative & support | 1984 |
| English Heritage Trading Limited | Administrative & support | 1994 |
| Enigma Electrical Limited | Wholesale & retail | 2002 |
| Enishi Limited | Professional & scientific | 2024 |
| Enjoy Development Limited | Information & communication | 2018 |
| Enjoy Play Limited | Other services | 2025 |
| Enlightening Escapes Ltd | Administrative & support | 2025 |
| Enright Accounting and Consultancy Services Limited | Professional & scientific | 2011 |
| Ensco 1281 Limited | Professional & scientific | 2018 |
| Enscription Limited | Professional & scientific | 2006 |
| Ensign Legal Services Limited | Professional & scientific | 2004 |
| Ensign Residential Property Ltd | Real estate | 2024 |
| Ent-Events Ltd | Arts & recreation | 2025 |
| Entelechy Consulting Limited | Professional & scientific | 2021 |
| Enter Stage Right LLP | | 2023 |
| Enterpride Music Ltd | Information & communication | 2024 |
| Enterprise Innovations Consulting Limited | Professional & scientific | 2013 |
| Enterprise Opinions Limited | Information & communication | 2007 |
| Entmedicolegalpractice Ltd | Health & social care | 2013 |
| Envictor Limited | Hospitality | 2019 |
| Enviro Pest Control Ltd | Professional & scientific | 2021 |
| Environmental Solutions (UK) Limited | Water & waste | 1999 |
| Envisage PMS Ltd | Construction | 2009 |
| Envy Tint & Wrap Limited | Wholesale & retail | 2020 |
| EP Swindon Solar Limited | Energy | 2017 |
| EPE Services Limited | Construction | 2019 |
| EPH Consultancy Limited | Professional & scientific | 2025 |
| Epic Production Services Limited | Other services | 2011 |
| Epic Property Investors Club Ltd | Real estate | 2018 |
| Epicare Health Ltd | Wholesale & retail | 2020 |
| Epix Limited | Other services | 1994 |
| Epoc Maintenance Ltd | Real estate | 2006 |
| Epoc Properties Ltd | Real estate | 2003 |
| Epoca Pharmaceuticals Ltd | Wholesale & retail | 2026 |
| EPP Coliving Ltd | Real estate | 2025 |
| EPP Property Investments Ltd | Real estate | 2025 |
| Epro Cleaning Services Ltd | Administrative & support | 2020 |
| EQ Interactive Limited | Professional & scientific | 2015 |
| EQL Stays Ltd | Hospitality | 2026 |
| Equi-Cessory Ltd | Wholesale & retail | 2024 |
| Equibreed UK Limited | Professional & scientific | 2010 |
| Equiceutica Ltd | Wholesale & retail | 2020 |
| Equigenetics Limited | Agriculture & fishing | 2018 |
| Equilogic Solutions Limited | Information & communication | 1997 |
| Equine Experts Limited | Administrative & support | 2026 |
| Equine Foot Clinic Limited | Professional & scientific | 2003 |
| Equine Performance Farriery Ltd | Other services | 2018 |
| Equinox Building Solutions (Swindon) Ltd | Construction | 2012 |