| SET Square Joinery Limited | Manufacturing | 2008 |
| Sevan Consulting Limited | Information & communication | 2008 |
| Seven Cars Limited | Other services | 2023 |
| Seven Stars 888 Limited | Hospitality | 2025 |
| Sevenfields Health Care Limited | Real estate | 2001 |
| Sevenhampton Associates Limited | Professional & scientific | 2017 |
| Seventeen Properties Ltd | Real estate | 2017 |
| Severn Logistics Ltd | Transport & logistics | 2010 |
| Seviin Ltd | Professional & scientific | 2010 |
| Sewallis Limited | Agriculture & fishing | 2012 |
| SFC Energy UK Limited | Professional & scientific | 2023 |
| Sferle Florin-Samuel Ltd | Transport & logistics | 2019 |
| Sff-Swimstars LLP | | 2022 |
| Sfhq Ltd | Arts & recreation | 2024 |
| Sfmz Limited | Real estate | 2026 |
| SFRH10 LLP | | 2024 |
| SFX Management Ltd | Administrative & support | 2021 |
| Sgoronga Ltd | Health & social care | 2020 |
| Sgproperty (Swindon)Ltd Ltd | Construction | 2021 |
| SGS Leisure Ltd | Arts & recreation | 2017 |
| SGT Clean Ltd | Administrative & support | 2019 |
| SH Security Ltd | Administrative & support | 2026 |
| Shad Property Solutions Limited | Real estate | 2025 |
| Shades of Coffee Ltd | Wholesale & retail | 2020 |
| Shaffi & Sons Limited | Real estate | 2011 |
| Shah Properties Development Ltd | Real estate | 2025 |
| Shahan Properties Ltd | Real estate | 2024 |
| Shahjalal Grocery Limited | Wholesale & retail | 2015 |
| Shahmaran Limited | Manufacturing | 2024 |
| Shaldon View Limited | Real estate | 2017 |
| Shalom Kitchen Limited | Wholesale & retail | 2025 |
| Shalom Logistics UK Ltd | Transport & logistics | 2019 |
| Sham 2024 Ltd | Hospitality | 2024 |
| Shamali Housing Ltd | Real estate | 2021 |
| Shamali Ltd | Health & social care | 2019 |
| Shamasa UK Ltd | Wholesale & retail | 2025 |
| Shamiso Care Ltd | Health & social care | 2020 |
| Shamrock Properties (Swindon) Ltd | Real estate | 2024 |
| Shan Construction&Renovation Ltd | Construction | 2026 |
| Shane & Dave Handyman Services Limited | Administrative & support | 2025 |
| Shane Eagles and Sons Ltd | Hospitality | 2025 |
| Shane Hobbs Farrier Limited | Other services | 2011 |
| Shape Apparel Limited | Manufacturing | 2020 |
| Shape Strategy Limited | Professional & scientific | 2021 |
| Shapes Ltd | Wholesale & retail | 2024 |
| Shara Petroleum Ltd | Wholesale & retail | 2018 |
| Sharayu & Suresh Ltd | Other services | 2022 |
| Sharcott Alpacas Limited | Arts & recreation | 2024 |
| Sharkey Structural Carpentry and Construction Ltd | Construction | 2024 |
| Sharkeys Property Group Ltd | Construction | 2024 |
| Sharland Roofing Limited | Construction | 1990 |
| Sharon's Beauty for ALL Ltd | Other services | 2018 |
| Sharp Angling Solutions Limited | Wholesale & retail | 2021 |
| Sharp Business Solutions Ltd | Professional & scientific | 2026 |
| Sharp Red Limited | Information & communication | 2021 |
| Sharp Transformations Limited | Professional & scientific | 2017 |
| Shaun Beck Ltd | Construction | 2017 |
| Shave Consulting Limited | Professional & scientific | 2017 |
| Shaver Kudell Manufacturing Limited | Wholesale & retail | 1991 |
| Shaw Court (Lydiard) Management Company Limited | Households | 1987 |
| Shaw Electrical & Plumbing Ltd | Construction | 2000 |
| Shaw Road Swindon Management Company Limited | Households | 2016 |
| Shaw Village DP Limited | Health & social care | 2025 |
| Shawcity Limited | Manufacturing | 1976 |
| Shayne Consultancy Ltd | Professional & scientific | 2025 |
| Shearwater Healthcare Ltd | Health & social care | 2023 |
| Sheba W (UK) Property Holding and Management Limited | Real estate | 2022 |
| Shedded Fitness Limited | Arts & recreation | 2001 |
| Shee & Family Properties Ltd | Real estate | 2021 |
| Sheen Motors Ltd | Wholesale & retail | 2026 |
| Shell Travel Ltd | Administrative & support | 2025 |
| Shell's Sexy Scents Ltd | Wholesale & retail | 2025 |
| Shemanages Properties Ltd | Households | 2026 |
| Shepard Way a RTM Company Limited | Households | 2024 |
| Shepard Way B RTM Company Limited | Households | 2024 |
| Shepard Way C RTM Company Limited | Households | 2024 |
| Shepard Way D RTM Company Limited | Households | 2024 |
| Shepard Way E RTM Company Limited | Households | 2024 |
| Shepard Way F RTM Company Limited | Households | 2024 |
| Shepard Way Management Company Ltd | Households | 2025 |
| Shepherd Lennox Associates Ltd | Professional & scientific | 2014 |
| Sheppard Trading Ltd | Wholesale & retail | 2026 |
| Sheq Excellence Group Ltd | Professional & scientific | 2025 |
| Sheqron Ltd | Professional & scientific | 2025 |
| Sherbourne ST John Limited | Construction | 2023 |
| Shere Khan Swindon Ltd | Hospitality | 2023 |
| Shergill Delivery Services Ltd | Transport & logistics | 2026 |
| Sherpa Mews Estate Management Ltd | Households | 2024 |
| Sherwani UK Ltd | Health & social care | 2019 |
| Sherwood Healthcare (UK) Limited | Wholesale & retail | 2011 |
| Shetland Pony Outreach CIC | Health & social care | 2026 |
| SHG Investments Ltd | Other services | 2018 |
| Shhe Ltd | Wholesale & retail | 2024 |
| SHI Ltd | Wholesale & retail | 2020 |
| Shield Electrical Services Limited | Construction | 2003 |
| Shield Guard Services Ltd | Administrative & support | 2025 |
| Shields Development Services Limited | Professional & scientific | 2018 |
| Shillings Enterprises Limited | Professional & scientific | 2003 |
| Shimitech Limited | Information & communication | 2013 |
| Shine Empire Limited | Transport & logistics | 2025 |