| Saas Capital Group Ltd | Hospitality | 2024 |
| Saasdotnet Limited | Information & communication | 2013 |
| SAB Heating and Plumbing Ltd | Construction | 2019 |
| Sabard Ltd | Information & communication | 2026 |
| Sabi Alonze Ltd | Real estate | 2025 |
| Sabira Bibi Jutt Ltd | Wholesale & retail | 2025 |
| Sabretooth Law Limited | Professional & scientific | 2004 |
| Sabrin Haulage Limited | Transport & logistics | 2018 |
| Sabrina & Anusha Ltd | Real estate | 2025 |
| Sabs Medical Ltd | Health & social care | 2023 |
| Sacala Construction Ltd | Construction | 2024 |
| Sackville Secretaries Limited | Professional & scientific | 2007 |
| Sacra Hypnotherapy Ltd | Health & social care | 2022 |
| SACRED4U Ltd | Transport & logistics | 2016 |
| Sadhana Infotech Limited | Information & communication | 2011 |
| Safaa Property Group Ltd | Real estate | 2025 |
| Safe & Secure Projects Limited | Professional & scientific | 2013 |
| Safe City Driving School Ltd | Education | 2025 |
| Safe Haven Global UK Limited | Public administration | 2024 |
| Safe Scents Ltd | Wholesale & retail | 2025 |
| Safe Start Safety & Training Services Ltd | Professional & scientific | 2014 |
| Safepilots Limited | Professional & scientific | 2020 |
| Safernoc Limited | Extraterritorial | 2020 |
| Safety and Consulting Limited | Administrative & support | 2024 |
| Safety Solution 365 Limited | Professional & scientific | 2025 |
| Safety, Technology & Legislation Limited | Other services | 1997 |
| Safewell Limited | Public administration | 2006 |
| Saffron Private Limited | Manufacturing | 2018 |
| Saffron-Sprite Art by Sarah Ltd | Arts & recreation | 2020 |
| Safi Fast Food Swindon Ltd | Hospitality | 2024 |
| Safitek Limited | Wholesale & retail | 2023 |
| Safu's Ltd | Hospitality | 2019 |
| Sagacity Education Ltd | Education | 2017 |
| Sagacity Technologies Limited | Information & communication | 2024 |
| Sahasra Fusion Technologies Limited | Information & communication | 2016 |
| Sahreen Property Ltd | Real estate | 2025 |
| SAI Kripa Transport Ltd | Transport & logistics | 2018 |
| SAI Krupaa Pharma Ltd | Professional & scientific | 2019 |
| Saiaryan Medical Limited | Health & social care | 2014 |
| Saimoab Consulting Ltd | Professional & scientific | 2022 |
| Saint Anthony Fish Supplies Ltd | Wholesale & retail | 2025 |
| Saint Anthony Security Ltd | Administrative & support | 2021 |
| Saint Ives Barber Ltd | Other services | 2025 |
| Saispurthi Ltd | Real estate | 2026 |
| Saiveda Limited | Information & communication | 2023 |
| Saiven Technology Solutions Ltd | Information & communication | 2014 |
| Sakthi Nkvs Company Ltd | Real estate | 2026 |
| Salaar ALI Limited | Wholesale & retail | 2024 |
| Salam's Restaurant Ltd | Hospitality | 2021 |
| Saleh Fast Food Ltd | Hospitality | 2025 |
| Sales Architecture Limited | Professional & scientific | 2012 |
| Salient Ideas Ltd | Professional & scientific | 2012 |
| Sally Hindley Associates Ltd | Wholesale & retail | 2002 |
| Salon 52 Limited | Other services | 2014 |
| SALON@8 Ltd | Other services | 2022 |
| Salpizza Ltd | Hospitality | 2025 |
| Salt and Light Counselling Services Ltd | Professional & scientific | 2014 |
| Saltash RTM Company Ltd | Households | 2023 |
| Salter Carpentry and Construction Limited | Manufacturing | 2016 |
| Salus Capital Partners Limited | Financial services | 2025 |
| SAM & Alen IT Solutions Limited | Information & communication | 2019 |
| SAM Automation Ltd | Manufacturing | 2018 |
| SAM IT Consultancy Services Ltd | Information & communication | 2018 |
| SAM Saeed Co Limited | Administrative & support | 2019 |
| Sama Kays Limited | Health & social care | 2019 |
| Samaajan Care Limited | Health & social care | 2017 |
| Samantha Jayne Limited | Professional & scientific | 2017 |
| Samaya Jade Ltd | Health & social care | 2025 |
| Sambourne House Antiques Limited | Wholesale & retail | 1999 |
| Sameground Limited | Information & communication | 2026 |
| Samian Consultancy Ltd | Administrative & support | 2006 |
| Samira Services Ltd | Health & social care | 2016 |
| Sammy's Kebab Calne Limited | Hospitality | 2024 |
| Sammys Takeaway Y&T Ltd | Hospitality | 2023 |
| Sampson Construction & Civils Ltd | Construction | 2025 |
| Sampson Lyon Legal Services Ltd | Administrative & support | 2015 |
| Samsco Limited | Health & social care | 2009 |
| Samsushi Ltd | Hospitality | 2025 |
| Samuel & Sons Properties Unlimited Ltd | Real estate | 2022 |
| Samurai Systems Ltd | Information & communication | 2012 |
| SAN Cepriano(Developments)Limited | Financial services | 1972 |
| Sanbal Express Ltd | Transport & logistics | 2021 |
| Sancellotti Ltd | Information & communication | 2021 |
| Sancho Logistics Ltd | Transport & logistics | 2024 |
| Sanctuary Security Solutions Ltd | Administrative & support | 2025 |
| Sand-Oak Property Group Ltd | Real estate | 2026 |
| Sanders Web Works Limited | Information & communication | 2018 |
| Sanderson-Doyle Consultancy Ltd | Construction | 2024 |
| Sandford Nextera Energy Ltd | Professional & scientific | 2026 |
| Sandgate 1970 Limited | Extraterritorial | 2014 |
| Sandgate RTM Company Ltd | Households | 2018 |
| Sandhu Associate UK Ltd | Transport & logistics | 2025 |
| Sandhu Consulting Limited | Professional & scientific | 2001 |
| Sandpark Garden Maintenance Ltd | Administrative & support | 2014 |
| Sandpool Detailing & Auto Services Ltd | Wholesale & retail | 2024 |
| Sandra Logistics Ltd | Transport & logistics | 2026 |
| Sandra Rogers Limited | Health & social care | 2013 |
| Sandra TIA Limited | Hospitality | 2021 |
| Sandymount Construction Ltd | Construction | 2011 |
| Sandymount Group Limited | Financial services | 2019 |