| Central Logistics Midlands Ltd | Transport & logistics | 2018 |
| Central Specialist Joinery Ltd | Manufacturing | 1972 |
| Central Transport Services (CTS) Ltd | Transport & logistics | 2021 |
| Central Travel (Woodville) Limited | Transport & logistics | 1979 |
| Centrum Self Storage Limited | Transport & logistics | 2005 |
| Ceramart UK Limited | Manufacturing | 2016 |
| Cerberus Midlands Limited | Education | 2024 |
| Cero Wheels Cycle Division Limited | Wholesale & retail | 2019 |
| CFW Electrical Ltd | Professional & scientific | 2023 |
| CG Aesthetics Lounge Limited | Other services | 2024 |
| CG Fish Bar Limited | Hospitality | 2021 |
| CG Gardens Limited | Administrative & support | 2025 |
| Chadwick Property Solutions Ltd | Real estate | 2025 |
| Chamberlain Place (Uttoxeter) Management Company Limited | Households | 2009 |
| Chamwish Builders Ltd | Construction | 2022 |
| Chapel Gate (Aldercar) Management Company Limited | Households | 2018 |
| Chapmans Nurseries Limited | Wholesale & retail | 2007 |
| Chapter Four Design Ltd | Other services | 2020 |
| Chargill (Holdings) Ltd | Extraterritorial | 2011 |
| Chargill CHL (Holdings) Limited | Financial services | 2018 |
| Chargill Ltd | Financial services | 2010 |
| Chargill Properties (Holding) Limited | Financial services | 2018 |
| Charkola Ltd | Hospitality | 2024 |
| Charles Webb Homes Limited | Hospitality | 2013 |
| Charlie and BOO Ltd | Wholesale & retail | 2019 |
| Chasewater Kart Racing Club | Arts & recreation | 1997 |
| Chatsworth Cabinets Limited | Wholesale & retail | 2016 |
| Chatsworth Gardens (Erdington) Management Company Limited | Households | 2003 |
| CHC OT Network Ltd | Health & social care | 2020 |
| Cheadle Royal Management Company Limited | Other services | 1995 |
| Cheaney Media Limited | Information & communication | 2023 |
| Cheeky Monkeys (Derbyshire) Ltd | Professional & scientific | 2019 |
| Cheersdecor Limited | Wholesale & retail | 2024 |
| Chellahospitality Limited | Hospitality | 2026 |
| Cherilyn Leeson Ltd | Wholesale & retail | 2023 |
| Cherry Orange Ltd | Information & communication | 2008 |
| Chestnut Bungalows Management Company Ltd | Households | 2021 |
| Chestnut Grange Residents Management Company Limited | Households | 2017 |
| Chestnut Valley Rebels Limited | Health & social care | 2002 |
| Chestnut Woodlands Forest School Limited | Education | 2016 |
| Chilled Hub Limited | Hospitality | 2020 |
| Chris Alsop Guitar Ltd | Manufacturing | 2020 |
| Chris Campbell Wealth Management Limited | Professional & scientific | 2021 |
| Christopher Luke Property Management Ltd | Real estate | 2022 |
| Chromic Solutions Limited | Construction | 2024 |
| Chuann Limited | Wholesale & retail | 2025 |
| Church Fields (Alfrick) Management Company Limited | Households | 2018 |
| Church Gresley (Old Hall) Bar Services Limited | Arts & recreation | 1996 |
| Church View (Belper) Management Company Limited | Households | 2005 |
| Church View (ST Ippolyts) Management Company Limited | Households | 2026 |
| Church View Breedon Management Company Limited | Households | 2017 |
| Churchills Atherstone Limited | Wholesale & retail | 2024 |
| Churchills Traditional Sweet Shop Ltd | Other services | 2022 |
| CI Advisers Limited | Financial services | 2022 |
| Cibvs Mondvs Ltd | Hospitality | 2024 |
| CID Express Ltd | Transport & logistics | 2021 |
| Cinar Properties Holding Ltd | Real estate | 2025 |
| Cinar Property Ltd | Real estate | 2022 |
| Citizens Advice MID Mercia | Information & communication | 2004 |
| Civil Engineering Monitoring Ltd | Professional & scientific | 2005 |
| CJ & JJ Lettings Ltd | Real estate | 2025 |
| Claire Reeves Coaching Ltd. | Health & social care | 2019 |
| Clarence Developments Limited | Real estate | 2009 |
| Claritech Holdings Limited | Information & communication | 2011 |
| Claritech Limited | Information & communication | 1995 |
| Clarke Aviation Services Limited | Transport & logistics | 2023 |
| CLB Surveys Ltd | Professional & scientific | 2015 |
| Clean Air Vehicles Limited | Wholesale & retail | 2012 |
| Clean Team 2018 Ltd | Administrative & support | 2018 |
| Clearway.Coach Ltd | Professional & scientific | 2024 |
| Cleat Hill Energy Limited | Energy | 2014 |
| Cleat Hill Feedstock Limited | Agriculture & fishing | 2015 |
| Clemkenzo Ltd | Professional & scientific | 2026 |
| Clgp Ltd | Hospitality | 2025 |
| Clickstep Ltd | Wholesale & retail | 2025 |
| Client Flow Collective Ltd | Administrative & support | 2026 |
| Clinic 20 Ltd | Other services | 2023 |
| CMJ Miller Ltd | Administrative & support | 2022 |
| CMM Business Solutions Limited | Professional & scientific | 2015 |
| CNS Care Ltd | Health & social care | 2024 |
| Coach House (Barton) Management Limited | Households | 2020 |
| Coachhouse Properties 2019 Ltd | Real estate | 2019 |
| Coalville Commercial Services Limited | Real estate | 1996 |
| Cobb Composites Ltd | Manufacturing | 2021 |
| Coelus Labs Ltd | Information & communication | 2026 |
| Collective Revolution C.I.C. | Hospitality | 2021 |
| Colliers Properties Limited | Real estate | 1959 |
| Colne House Property Limited | Real estate | 2013 |
| Colombier Vins Fins Limited | Wholesale & retail | 1974 |
| Comfort-Tech Ltd | Wholesale & retail | 2004 |
| Commercial Domestic Solar Ltd | Construction | 2025 |
| Commercial Remarketing Services Limited | Wholesale & retail | 2003 |
| Commercial Vehicle Products Limited | Wholesale & retail | 2012 |
| Common Sense Safety Limited | Administrative & support | 2026 |
| Community Transport (Swadlincote) | Transport & logistics | 1994 |
| Complete Enabling Services Ltd | Construction | 2024 |
| Complete Pet Care (UK) Limited | Professional & scientific | 2013 |
| Computer Administration and Development Services Limited | Information & communication | 1999 |
| Computer Development and Epos Services Limited | Information & communication | 2009 |
| Computers and Vapes Ltd | Other services | 2017 |