| Sedat Kâzim Ltd | Construction | 2025 |
| SEE WOO Long Limited | Hospitality | 2015 |
| Seeedsuk Limited | Education | 2021 |
| Seeone BEL Ltd | Wholesale & retail | 2021 |
| Seethamraju Property Ltd | Real estate | 2023 |
| Sehajpal PVT. Ltd. | Professional & scientific | 2015 |
| Select Removals Limited | Transport & logistics | 2025 |
| Selected Group Ltd | Administrative & support | 2019 |
| Selenite Consultants Limited | Professional & scientific | 2021 |
| Sell My House Fast Ltd | Real estate | 2024 |
| Sellocity Ltd | Wholesale & retail | 2025 |
| Selsella Ltd | Wholesale & retail | 2018 |
| Selvarani Assets Limited | Real estate | 2023 |
| Semkovi Ltd | Construction | 2014 |
| Semwal Consulting Limited | Wholesale & retail | 2020 |
| SEN Medical (London) Ltd | Health & social care | 2024 |
| SEN Medical Aesthetics Limited | Health & social care | 2023 |
| Send Soul Ltd | Information & communication | 2018 |
| Senfresh Ltd | Wholesale & retail | 2023 |
| Senior Roofing Ltd | Construction | 2025 |
| Senoa Limited | Real estate | 2021 |
| Sensu Investments Limited | Health & social care | 2016 |
| Sensu London Limited | Health & social care | 2014 |
| Sentience Investments Ltd | Real estate | 2023 |
| SEP Wholesale Limited | Wholesale & retail | 2019 |
| Seran Infotech Ltd | Information & communication | 2012 |
| Seraphim (UK) Limited | Administrative & support | 2008 |
| Serendip British Investment Ltd | Real estate | 2020 |
| Serendipity Dental Ltd | Health & social care | 2026 |
| Serendpidity Limited | Health & social care | 2011 |
| Serjo to Ltd | Transport & logistics | 2024 |
| Serntech Ltd | Administrative & support | 2025 |
| Service Charge Assurance Limited | Professional & scientific | 2008 |
| Service Crew Ltd | Other services | 2000 |
| Serwan Barbers (Surrey) Ltd | Other services | 2017 |
| SET for the NET Limited | Wholesale & retail | 2000 |
| Seth Infotech Limited | Information & communication | 2011 |
| Seven Yield Renewables Limited | Administrative & support | 2020 |
| Seymour Management Company (Sutton) Limited | Households | 1987 |
| SF Finance Limited | Financial services | 2018 |
| SFM Film Limited | Information & communication | 2006 |
| SFX Mouldings Ltd | Construction | 2015 |
| SG Decorating Ltd | Construction | 2016 |
| SGM Security Group Ltd | Administrative & support | 2024 |
| Sgspta Limited | Education | 2007 |
| SH Technology Ltd | Information & communication | 2022 |
| SHA UK Trading Limited | Hospitality | 2019 |
| Shadbolt & Sons Limited | Wholesale & retail | 2016 |
| Shadelegal Limited | Professional & scientific | 2021 |
| Shades Systems Ltd | Administrative & support | 2016 |
| Shadow Perform Ltd | Wholesale & retail | 2019 |
| Shahid Abbas Limited | Wholesale & retail | 2024 |
| Shail Homes Ltd | Real estate | 2025 |
| Shajara IT Consultants Limited | Information & communication | 2023 |
| Shakthi K Limited | Real estate | 2025 |
| Shakti Unnati Limited | Health & social care | 2018 |
| Shalom Surrey Limited | Wholesale & retail | 2017 |
| Shamana Investments Limited | Real estate | 2021 |
| Shapeup Interiors Limited | Construction | 2025 |
| Shapla Sutton Ltd | Real estate | 2018 |
| Sharad Tech Ltd. | Information & communication | 2014 |
| Sharad Tech Properties Limited | Real estate | 2022 |
| Share a Smile Gifts Ltd | Wholesale & retail | 2024 |
| Share Biotechnologies Limited | Professional & scientific | 2025 |
| Shareka Aesthetics Ltd | Health & social care | 2018 |
| Sharuz Ltd | Hospitality | 2020 |
| Shaz Accountancy Limited | Professional & scientific | 2014 |
| Sheba Real Estate Limited | Real estate | 2023 |
| Sheehy Developments Limited | Construction | 2021 |
| Shenoy Psychology Services Ltd | Professional & scientific | 2014 |
| Sherazi Solutions Ltd | Information & communication | 2026 |
| Sherwood Park Road Management Company Limited | Households | 2000 |
| Shield Group Limited | Financial services | 2005 |
| Shield Resin Technologies Ltd | Administrative & support | 2023 |
| Shinobisoft Limited | Information & communication | 2014 |
| Shivaarj Ltd | Wholesale & retail | 2022 |
| Shivaarjasset Commercial Limited | Real estate | 2026 |
| Shivam Engineers Limited | Manufacturing | 2008 |
| Shivam Surrey Ltd | Real estate | 2018 |
| Shivan Pharma Limited | Professional & scientific | 2021 |
| Shivay Infotech Ltd | Information & communication | 2019 |
| Shjl Ltd | Wholesale & retail | 2016 |
| Shmeza Ltd | Wholesale & retail | 2022 |
| SHN Holdings Ltd | Real estate | 2024 |
| Shopquo Limited | Wholesale & retail | 2024 |
| Short Lease Rescue Limited | Real estate | 2025 |
| Shortest Path Software Ltd | Information & communication | 2025 |
| Showarch Developments Limited | Real estate | 1987 |
| Showskills Ltd | Arts & recreation | 2023 |
| Shree Ganesh Counsaltancy Ltd | Real estate | 2025 |
| Shreeji MJ Limited | Other services | 2024 |
| Shreya Consulting Ltd | Information & communication | 2016 |
| Shreya Property Investment Company Limited | Real estate | 2022 |
| Shri Saiganesha Limited | Health & social care | 2022 |
| Shringarpure Properties Ltd | Real estate | 2019 |
| Shuttlefish Creative Limited | Information & communication | 2013 |
| Sidcup Oriental Ltd | Hospitality | 2019 |
| Sidda House Limited | Real estate | 1964 |
| Sider Bakalov Ltd | Construction | 2022 |
| Sidjo Global Ltd | Wholesale & retail | 2025 |