| S C a L T R O Investment Co. Limited | Extraterritorial | 2023 |
| S C Diamond Property Services Ltd | Construction | 2023 |
| S C Media Solutions Ltd | Information & communication | 2017 |
| S C Q Ltd | Construction | 2004 |
| S J Daniell Ltd | Construction | 2008 |
| S J MEW Developments Limited | Construction | 2023 |
| S J Pittman Limited | Health & social care | 2000 |
| S J Waste Ltd | Other services | 2020 |
| S K D (UK) Ltd | Wholesale & retail | 2012 |
| S Lewarne Limited | Wholesale & retail | 2012 |
| S M Galande Ltd | Wholesale & retail | 2025 |
| S Moger Ductwork Services Ltd | Construction | 2015 |
| S Neville Properties Ltd | Real estate | 2021 |
| S P Athletic Limited | Arts & recreation | 2017 |
| S Rhodes Consulting Ltd | Information & communication | 2018 |
| S T Heating Ltd | Construction | 2021 |
| S W Forecast Limited | Professional & scientific | 1997 |
| S&B Maintenance Ltd | Construction | 2021 |
| S&K Builders Limited | Construction | 2020 |
| S&S Assets Management Limited | Real estate | 2022 |
| S&S Carpentry Joinery Ltd | Construction | 2012 |
| S&S Transport Ltd | Transport & logistics | 2025 |
| S-Ameer Properties Ltd | Real estate | 2016 |
| S-Cube Software Solutions Ltd | Information & communication | 2012 |
| S. Neville and Company Ltd | Professional & scientific | 2015 |
| S.G. Barai Limited | Other services | 2002 |
| S.L.N.B. Limited | Arts & recreation | 1985 |
| S.M.Pineger 2 Ltd | Hospitality | 2018 |
| S.V.S. Designs Limited | Manufacturing | 2008 |
| S.Warrender & Co. | Wholesale & retail | 1962 |
| S11 Advisory Ltd | Information & communication | 2020 |
| S4 PVT Ltd | Professional & scientific | 2023 |
| SA Business Ltd | Financial services | 2018 |
| SA Super Store Ltd | Wholesale & retail | 2025 |
| SA Theatre International Ltd | Arts & recreation | 2024 |
| Sa.Pa Authentic Italian Food Ltd | Other services | 2015 |
| Saachi Properties Limited | Real estate | 2016 |
| Saadat Consulting Limited | Professional & scientific | 2013 |
| Sabaci Ltd | Real estate | 2020 |
| Sabby G Ltd | Information & communication | 2023 |
| Sacglobal Ltd | Professional & scientific | 2023 |
| Sadadi Construction Ltd | Professional & scientific | 2019 |
| Sadra & Mahsa Financial Services Limited | Financial services | 2019 |
| Sadra & Mahsa Property Limited | Real estate | 2017 |
| Safeclick Digital Solutions Limited | Information & communication | 2011 |
| Safee Trader Ltd | Administrative & support | 2022 |
| Safelodge Rental Limited | Real estate | 2023 |
| Saferide Transport Ltd | Wholesale & retail | 2026 |
| Safeworld Limited | Administrative & support | 2021 |
| Saffa Solutions Ltd | Information & communication | 2018 |
| Safi Driving School Limited | Education | 2020 |
| Safran Developments Hampshire Ltd | Construction | 2018 |
| Sage Holistic Ltd | Health & social care | 2025 |
| Sage Media Limited | Information & communication | 2005 |
| Saha Devops Ltd | Information & communication | 2025 |
| Sahnazu Ltd | Wholesale & retail | 2026 |
| Sahoo Consulting Ltd | Information & communication | 2011 |
| SAI Anugraha Limited | Information & communication | 2010 |
| SAI Consultants Ltd | Professional & scientific | 2024 |
| SAI Creations Limited | Education | 2011 |
| SAI HOE & SON Company Limited | Households | 2024 |
| SAI Saansar UK Ltd | Information & communication | 2018 |
| SAI Software Solutions Limited | Information & communication | 2018 |
| SAI Tutors Limited | Education | 2019 |
| Saidul Islam Limited | Health & social care | 2015 |
| Saijanthran Consultancy Limited | Information & communication | 2018 |
| Saint James Auto Services Ltd | Wholesale & retail | 2001 |
| Saish Merch Ltd | Wholesale & retail | 2025 |
| Saishiv Services Ltd | Professional & scientific | 2024 |
| Sajo (UK) Ltd | Professional & scientific | 2011 |
| Salamath Gems Ltd | Wholesale & retail | 2009 |
| Salao DE Cabeleleira Ltd | Administrative & support | 2025 |
| Sale Electrical Services Ltd. | Extraterritorial | 2000 |
| Sale Group Holdings Limited | Financial services | 2021 |
| Sale Group Limited | Extraterritorial | 2007 |
| Sale Group Properties Limited | Financial services | 2021 |
| Sale Maintenance Ltd | Administrative & support | 2007 |
| Sale Nugen Limited | Construction | 2009 |
| Sale Service and Maintenance Ltd. | Construction | 2000 |
| Saleemexpress Limited | Wholesale & retail | 2017 |
| Saleh&Luxe Limited | Wholesale & retail | 2025 |
| Sales Hacker Ltd | Professional & scientific | 2022 |
| Sally Sweet and Sour Ltd | Hospitality | 2025 |
| Salon Gold Limited | Professional & scientific | 2025 |
| Salon Saver Limited | Professional & scientific | 2025 |
| Saltdean Ltd | Wholesale & retail | 2011 |
| Salus Trading LLP | | 2011 |
| SAM Design & Build Ltd | Construction | 2017 |
| SAM Engineering Services Limited | Professional & scientific | 2017 |
| SAM Solicitors Ltd | Professional & scientific | 2021 |
| Samantha Ltd | Health & social care | 2016 |
| Samara Engineering Works Limited | Wholesale & retail | 2025 |
| Samasama Limited | Real estate | 2018 |
| Samatadan Ltd | Real estate | 2022 |
| Sami Retail Limited | Wholesale & retail | 2017 |
| Samir Security Ltd | Administrative & support | 2022 |
| Sammies Studio Limited | Other services | 2019 |
| Sampoornam Software Ltd | Information & communication | 2019 |
| Sams United Cars Ltd | Wholesale & retail | 2017 |
| Samuel Advisors (UK) Ltd | Information & communication | 2021 |