| Scientific Girlie Ltd | Health & social care | 2025 |
| Scott Beardsley Timber Sales Limited | Wholesale & retail | 2020 |
| Scott Machine Solutions Ltd | Manufacturing | 2021 |
| Sculpting Futures Education Ltd | Education | 2025 |
| SD Commercial Services Limited | Construction | 2022 |
| SDA Consulting Engineers Limited | Construction | 2010 |
| SDP 2011 Limited | Professional & scientific | 2011 |
| Sea Fish & Grill Ltd | Hospitality | 2025 |
| Sea Pearl Ltd | Hospitality | 2020 |
| Seceuro Systems Ltd. | Construction | 2007 |
| Secura Windows and Doors Limited | Construction | 2020 |
| Securitec Fire & Security Ltd | Administrative & support | 2020 |
| Selcon Ltd | Construction | 2020 |
| Seli Car Repair Ltd | Wholesale & retail | 2023 |
| Sell Distribution GB Ltd | Wholesale & retail | 2025 |
| Sentry Consulting Limited | Administrative & support | 2013 |
| Sesame Investments Limited | Real estate | 2019 |
| Sethi Properties Nottingham Ltd | Real estate | 2022 |
| SF Bespoke Joinery Ltd | Construction | 2025 |
| Shaju Limited | Wholesale & retail | 2018 |
| Shared Housing Group Ltd | Real estate | 2025 |
| Sharp Professional Catering Services Ltd | Hospitality | 2014 |
| SHARPAS4 Ltd | Wholesale & retail | 2020 |
| SHE Management Solutions Limited | Professional & scientific | 2016 |
| SHE Quality Solutions Ltd | Professional & scientific | 2018 |
| Sherwood Knowledge Limited | Education | 2016 |
| Shonsales Ltd | Other services | 2025 |
| Shopy Force Ltd | Information & communication | 2018 |
| Shot Blast Services UK Ltd | Professional & scientific | 2025 |
| Shotblast Spares Ltd | Wholesale & retail | 2013 |
| Sign Power Limited | Other services | 2012 |
| Silver Linings Education Ltd | Education | 2023 |
| Simon Hodgson GAS Services Ltd | Energy | 2022 |
| Simple Box UK Ltd | Transport & logistics | 2025 |
| Sina Spa Ltd | Other services | 2024 |
| SIR Lancelot Logistics Ltd | Transport & logistics | 2023 |
| SJB Elec Ltd | Construction | 2017 |
| Sjds Developments Limited | Real estate | 2024 |
| SJF Accountants Limited | Professional & scientific | 2009 |
| SJU Healthcare Limited | Health & social care | 2019 |
| SK Detailing Services Ltd | Construction | 2012 |
| Skcl Properties Limited | Real estate | 2023 |
| Skegby Properties Limited | Real estate | 2003 |
| Skegby Residences Company Limited | Administrative & support | 1997 |
| Skegness Statics Limited | Other services | 2023 |
| Skoped Limited | Administrative & support | 2026 |
| Skuific Limited | Transport & logistics | 2023 |
| Sky Plas Limited | Manufacturing | 2009 |
| Slaters Contracting and Consultancy Ltd | Administrative & support | 2024 |
| SLG Commercials Ltd | Wholesale & retail | 2021 |
| Smart Evolution 2025 Ltd | Wholesale & retail | 2025 |
| Smart Home Contracts Limited | Construction | 2024 |
| Smart Hometech Services Limited | Construction | 2024 |
| SMF Engineering Services Ltd | Professional & scientific | 2024 |
| Soggy Doggie Ltd | Other services | 2019 |
| SOL Looking Sunny Ltd | Wholesale & retail | 2025 |
| Solar Calibre Doors Ltd | Manufacturing | 2020 |
| Solar Fabrications Holdings Limited | Financial services | 2020 |
| Solar Norvik Ltd | Construction | 2020 |
| SON Portfolios Ltd | Real estate | 2019 |
| Sosorente Services Ltd | Administrative & support | 2025 |
| Spacey Property Investments Ltd | Administrative & support | 2024 |
| SPC Commercial Management Limited | Real estate | 2025 |
| Specialized Shot Peening Ltd | Construction | 2014 |
| SPG Safety Limited | Education | 2011 |
| Sphe Holdings Limited | Construction | 2014 |
| SPM Quality Care Limited | Health & social care | 2013 |
| Springfield Farm and Cottage Ltd | Agriculture & fishing | 2026 |
| SPS Property Group Limited | Real estate | 2019 |
| Sqrd Ltd | Other services | 2025 |
| SS Fencing and Forestry Limited | Construction | 2025 |
| Sssa Limited | Real estate | 2025 |
| Sstd & Co Limited | Wholesale & retail | 2026 |
| Standout Leadership Consultancy Ltd | Professional & scientific | 2026 |
| Staniland Properties Ltd | Construction | 2026 |
| Stanley Accommodations Ltd | Real estate | 2026 |
| Stan’S Stable Ltd | Agriculture & fishing | 2023 |
| Star Short Stays UK Ltd | Real estate | 2024 |
| Staticholding Ltd | Wholesale & retail | 2024 |
| Station Motors (Sutton) Ltd | Wholesale & retail | 2010 |
| Stay With Rich Limited | Hospitality | 2025 |
| Stbn Serviced Accommodation Ltd | Hospitality | 2023 |
| STE Martin Properties Ltd | Real estate | 2022 |
| Steel Groundworks Ltd | Construction | 2024 |
| Stellar Training Solutions Limited | Professional & scientific | 2012 |
| Stonepoppy Property Management Limited | Hospitality | 2007 |
| Stonewall Developments Ltd | Financial services | 2023 |
| Stoneyford SC Ltd | Health & social care | 2022 |
| Storenest Self Storage Limited | Transport & logistics | 2025 |
| Storm Security Solutions Ltd | Administrative & support | 2025 |
| Street Coffee M&K Ltd | Hospitality | 2018 |
| Strive Soccer Ltd | Education | 2026 |
| Studio a Branding & Web Ltd | Information & communication | 2020 |
| Stwa Enterprise Ltd | Financial services | 2017 |
| Subtronix Limited | Manufacturing | 2013 |
| Summercourt Accounting Ltd | Professional & scientific | 2023 |
| Sunny Accountants Limited | Professional & scientific | 2012 |
| Sunny Self Storage Limited | Transport & logistics | 2015 |
| Sunview Home Improvements Ltd | Construction | 2017 |
| Super Fit Tyres Ltd | Wholesale & retail | 2016 |