| S J Training Consultancy Limited | Education | 2024 |
| S JAY Investments Ltd | Real estate | 2024 |
| S Johnson Wealth Management LLP | | 2014 |
| S M James Limited | Health & social care | 2025 |
| S Nutt Sewing Machines Ltd | Wholesale & retail | 2020 |
| S Plan Limited | Wholesale & retail | 2022 |
| S R Holdings Midlands Limited | Real estate | 2026 |
| S Razak Transport Ltd | Transport & logistics | 2016 |
| S S Road Haulage Ltd | Transport & logistics | 2019 |
| S Wellens & Sons Limited | Extraterritorial | 1951 |
| S&A Highbridge Holdings Ltd | Real estate | 2026 |
| S&B Real Estate Ltd. | Hospitality | 2017 |
| S&B Zone CUT Ltd | Other services | 2024 |
| S&E Property Investments Limited | Real estate | 2026 |
| S&P Investment Capital Ltd | Wholesale & retail | 2020 |
| S&W Trading Limited | Wholesale & retail | 2018 |
| S-T Property Investors Limited | Real estate | 2015 |
| S.A. & P.I Colston Properties LLP | | 2016 |
| S.A. Spence Limited | Professional & scientific | 1998 |
| S.A.Bates and Sons Limited | Extraterritorial | 1954 |
| S.I.E.C. Limited | | 1979 |
| S.J.M. Independent Funeral Directors Limited | Other services | 2022 |
| S.O. Ventures Limited | Professional & scientific | 2021 |
| S.O.L. Management Ltd | Real estate | 2006 |
| S.P.A. Healthcare Limited | Health & social care | 2007 |
| S.P.B. Electrical Services Ltd | Other services | 2005 |
| S.R. Renovations Ltd | Construction | 2023 |
| S.S.M Optics Ltd | Health & social care | 2016 |
| S@W Ltd | Health & social care | 2024 |
| SA Sutton Ltd | Hospitality | 2025 |
| SA the Specialist Ltd | Education | 2013 |
| Saakaar Orthopaedics Ltd | Administrative & support | 2019 |
| Saaz Estates Ltd | Real estate | 2023 |
| Sabh 13 Limited | Real estate | 2021 |
| Sabio Trading Ltd | Health & social care | 2026 |
| Sabri Goods Limited | Wholesale & retail | 2014 |
| SAC Legal Limited | Professional & scientific | 2026 |
| Sacred Heart Ltd | Administrative & support | 2019 |
| Saddleworth Limited | Professional & scientific | 1979 |
| Sadler House Properties Limited | Real estate | 2025 |
| Sadozai Medical Services Limited | Health & social care | 2023 |
| Safe GAS Detection Limited | Administrative & support | 2020 |
| Safe Space Properties Limited | Real estate | 2026 |
| Safetax Limited | Professional & scientific | 1996 |
| Saffron Group Holdings Ltd | Financial services | 2026 |
| Saffron Realty Ltd | Real estate | 2026 |
| Safi Medical Ltd | Extraterritorial | 2021 |
| Saftway Limited | Extraterritorial | 1974 |
| Saha Locums Limited | Health & social care | 2013 |
| Sahaara CIC | Education | 2026 |
| Sahota & Co Properties Ltd | Real estate | 2025 |
| Sahota Home Improvement Ltd | Manufacturing | 2022 |
| SAI Thulasi Limited | Wholesale & retail | 2023 |
| Saifur Ltd | Hospitality | 2024 |
| Sail Property Ventures Ltd | Real estate | 2026 |
| Saiyo Consulting Ltd | Administrative & support | 2023 |
| Salabe Limited | Construction | 2016 |
| Salary Insider Limited | Professional & scientific | 2025 |
| Salenew Limited | Extraterritorial | 1979 |
| Sales Closers Limited | Professional & scientific | 2020 |
| Salient Alliances Limited | Real estate | 2017 |
| Sally Wagstaff Aesthetics Ltd | Other services | 2013 |
| Salo Developments Limited | Construction | 2023 |
| Salo Holdings Limited | Financial services | 2025 |
| Salo Spaces Limited | Construction | 2025 |
| Salon Express Hair & Beauty Limited | Wholesale & retail | 2024 |
| Salsus Limited | Professional & scientific | 2012 |
| Saltbury Limited | Hospitality | 2023 |
| Salz Window Installations Ltd | Construction | 2025 |
| Sal’S News & Booze Limited | Wholesale & retail | 2019 |
| Sama.K Transport Limited | Transport & logistics | 2026 |
| Saman Consulting Ltd | Information & communication | 2024 |
| Samlor Consulting Ltd | Professional & scientific | 2016 |
| Samteviot Ltd | Real estate | 2018 |
| San&Aydan Household Solutions Limited | Other services | 2025 |
| Sana B&H Ltd | Other services | 2023 |
| Sana Dream Looks Ltd | Other services | 2023 |
| Sanaro Limited | Extraterritorial | 2022 |
| Sanatate Medical Services Limited | Health & social care | 2014 |
| Sand Safety Health and Environmental Limited | Professional & scientific | 2005 |
| Sandcliff Limited | Other services | 2024 |
| Sandcroft Property Limited | Real estate | 2023 |
| Sanders Goodale & Co.Limited | Extraterritorial | 1938 |
| Sanders Homes Limited | Real estate | 2022 |
| Sandhu Estates Limited | Real estate | 2014 |
| Sandhu Properties & Investments Ltd | Real estate | 2024 |
| Sandhu Solicitors Limited | Real estate | 2019 |
| Sandiacre Fish Bar Limited | Hospitality | 2024 |
| Sandy Croft Residents Company Limited | Households | 2004 |
| Saneil Samrai Ltd. | Professional & scientific | 2016 |
| Sanfil Limited | Information & communication | 2013 |
| Sanford Barnes Holdings Limited | Administrative & support | 2014 |
| Sanghera & Co Ltd | Wholesale & retail | 2001 |
| Sankeys Fish Bar Limited | Hospitality | 2010 |
| Santa Marina Properties Limited | Real estate | 2017 |
| Santa's Reindeer Limited | Arts & recreation | 2017 |
| Santino Consultancy Limited | Professional & scientific | 2012 |
| Saphire Windscreens B'Ham Ltd | Wholesale & retail | 2019 |
| Sapling Brown Limited | Real estate | 2017 |
| Sapphire Hair & Beauty Limited | Other services | 2014 |