| U&G Travel and Tours Limited | Administrative & support | 2025 |
| Uatopia Limited | Information & communication | 2013 |
| UK Energy Management Group Ltd | Professional & scientific | 2017 |
| UK Facilities Management Company Ltd | Administrative & support | 2014 |
| UK Gateway Education Hub CIC | Education | 2024 |
| UK Pandora Properties Limited | Real estate | 2025 |
| UK Plug ME Ltd | Professional & scientific | 2023 |
| UK Pool Shells Ltd | Construction | 2018 |
| UK Special Projects Interiors Ltd | Construction | 2025 |
| UK Special Projects Limited | Construction | 2021 |
| UK Swimming Pool Construction Limited | Professional & scientific | 2016 |
| UKI Solutions Limited | Information & communication | 2015 |
| Ukmc Canteen Limited | Hospitality | 2026 |
| Uksp Ventures Ltd | Financial services | 2024 |
| Ultimate Fire & Smoke Curtains Holdings Ltd Ltd | Manufacturing | 2023 |
| Ultimate Fire & Smoke Curtains Ltd | Manufacturing | 2018 |
| Ultimate Rugby 7S UK Ltd | Arts & recreation | 2025 |
| Ultimate Utility Brokers Ltd | Administrative & support | 2010 |
| Undapp Technologies Ltd | Information & communication | 2023 |
| Uniblend Consult Ltd | Professional & scientific | 2010 |
| Unioncare Consult Ltd | Administrative & support | 2022 |
| Unique Aura Limited | Extraterritorial | 2023 |
| Unique Barber Chiswick Limited | Other services | 2025 |
| Unique Driveways and Patios Ltd | Administrative & support | 2022 |
| Unique Performance Coaching Ltd | Arts & recreation | 2022 |
| Unique Properties NE Ltd | Real estate | 2023 |
| Unique Tour and Travel Ltd | Administrative & support | 2018 |
| Unique Tyne&Wear Barber Limited | Other services | 2024 |
| Unique's Emporium Ltd | Hospitality | 2025 |
| Uniquecleaningx Ltd | Administrative & support | 2024 |
| Unite Telecoms Ltd | Information & communication | 2018 |
| United Design & Build Limited | Construction | 2016 |
| Unity in Community Sunderland Community Interest Company | Other services | 2005 |
| Universal Bedding and Upholstery (1998) Limited | Water & waste | 1998 |
| University of Sunderland Enterprises Limited | Administrative & support | 1990 |
| University of Sunderland London Campus Limited | Education | 2012 |
| University of Sunderland Students' Union | Wholesale & retail | 2011 |
| Unleash Ltd. | Professional & scientific | 2005 |
| Unleashed Discovery Ltd | Professional & scientific | 2025 |
| Unlocked Potential Training Ltd | Education | 2026 |
| UNO Pizzeria Limited | Hospitality | 2017 |
| UOS Employee Services Limited | Administrative & support | 2024 |
| Uplift - Investing in YOU Community Interest Company | Education | 2015 |
| Uplift Associates Ltd | Education | 2011 |
| Uplift Business Support Ltd | Administrative & support | 2025 |
| Uplift Group Ltd | Education | 2021 |
| Upstitch & Mend CIC | Education | 2025 |
| Urban Decorating Services Ltd | Construction | 2018 |
| Urban Ease Properties Ltd | Real estate | 2025 |
| Urban Geography Ltd | Professional & scientific | 2022 |
| Urban Sales Ltd | Wholesale & retail | 2024 |
| Urbangro Market Ltd | Wholesale & retail | 2025 |
| Urbanscope Media Limited | Professional & scientific | 2025 |
| Uschem Ltd | Wholesale & retail | 2022 |
| Used Truck Spares Limited | Wholesale & retail | 2018 |
| Usher Events Ltd | Arts & recreation | 2024 |
| Usmanahmed Ltd | Wholesale & retail | 2025 |
| Uthoria Project Ltd | Wholesale & retail | 2022 |
| Utilink Consulting Limited | Energy | 2021 |
| Utilink Holdings Limited | Financial services | 2025 |
| Utilitylife Consulting Limited | Professional & scientific | 2020 |
| V & Z Enterprises Ltd | Professional & scientific | 2022 |
| V Ciliberti Ltd | Real estate | 2023 |
| Vacant Nests Group Limited | Real estate | 2026 |
| Vacant Nests Interiors Limited | Construction | 2024 |
| Vacant Nests Limited | Real estate | 2020 |
| Vacant Nests Property Management Limited | Real estate | 2025 |
| Valentine Rope Access Ltd | Construction | 2023 |
| Vallely House Ltd | Wholesale & retail | 2025 |
| Valyrian Properties Ltd | Real estate | 2020 |
| Vams Enterprise Ltd | Wholesale & retail | 2024 |
| Van Hessen UK Casings Ltd | Manufacturing | 1979 |
| Van Hessen UK Operations Ltd | Wholesale & retail | 2018 |
| Van Solutions (NE) Ltd | Wholesale & retail | 2025 |
| Vanee Convenience Store Ltd | Wholesale & retail | 2026 |
| Vangmayi Ltd | Wholesale & retail | 2018 |
| Vanguards Healthcare Ltd | Public administration | 2023 |
| Vanishing Point Data Logic Ltd | Information & communication | 2018 |
| Vantage Community Housing CIC | Construction | 2026 |
| Vantara Risk Management Ltd | Professional & scientific | 2026 |
| Vape & Candy Shop(Ne) Ltd | Wholesale & retail | 2026 |
| Vape City (NE) Ltd | Wholesale & retail | 2025 |
| Vape Lagoon (NE) Limited | Wholesale & retail | 2026 |
| Vape Lagoon North East Ltd | Wholesale & retail | 2025 |
| Vaping Secrets Ltd | Wholesale & retail | 2017 |
| VAR Daily Ltd | Wholesale & retail | 2025 |
| Varba 1 Ltd | Professional & scientific | 2025 |
| Vardhin Limited | Wholesale & retail | 2026 |
| Vardy Consulting Ltd | Professional & scientific | 2005 |
| Varley Properties Limited | Real estate | 2020 |
| Vartex Limited | Information & communication | 2017 |
| Varyk Ltd | Other services | 2023 |
| Vasey Ltd | Real estate | 2022 |
| Vaux Brewery (Holdings) Ltd | Financial services | 2019 |
| Vaux Brewery (Sunderland) Ltd | Manufacturing | 2012 |
| Vaux Management Company Limited | Real estate | 2017 |
| Vazoo Ltd | Wholesale & retail | 2025 |
| VD Holdings Ltd | Financial services | 2023 |
| Vector Capital Investments Limited | Real estate | 2021 |
| Veda Group Ltd | Professional & scientific | 2020 |