| Shakira Sammy Property Limited | Households | 2021 |
| Sham North Ltd | Hospitality | 2025 |
| Shams Thebo Ltd | Wholesale & retail | 2025 |
| Shandiz Mediterranean Limited | Hospitality | 2022 |
| Shapes Ryhope Ltd | Other services | 2020 |
| Sharan Site Services Limited | Construction | 2025 |
| Sharp Focus Cctv Limited | Professional & scientific | 2017 |
| Sharpin Morgan Jayne Ltd | Wholesale & retail | 2026 |
| Sharprr Limited | Professional & scientific | 2025 |
| Shaun Flanagan Ltd | Construction | 2021 |
| Shawrma Express Ltd | Hospitality | 2025 |
| Shawrma House Ltd | Hospitality | 2024 |
| Shaws Motors Ltd | Wholesale & retail | 2023 |
| Sheaker Limited | Wholesale & retail | 2025 |
| Sheepfolds Leisure Limited | Hospitality | 2023 |
| Sheikh Traders 149 Ltd | Wholesale & retail | 2026 |
| Shell & NIK Ltd | Hospitality | 2023 |
| Shemrun Ltd | Extraterritorial | 2019 |
| Shenton Engineering Limited | Construction | 2001 |
| Shepherd Properties North East Ltd | Real estate | 2023 |
| Shergold Homes Limited | Construction | 2025 |
| Shieldmanner Limited | Real estate | 1993 |
| Shinally Services Limited | Health & social care | 2024 |
| SHINOB1 Limited | Hospitality | 2025 |
| Shipwrights Hotel Ltd | Hospitality | 2012 |
| Shirine Ltd | Health & social care | 2022 |
| Shiva Building Services Ltd. | Construction | 2018 |
| Shiva Travel Gasht Ltd | Administrative & support | 2018 |
| Shooting Services Limited | Wholesale & retail | 2010 |
| Shopfitter Ltd | Construction | 2018 |
| Short Daisies LLP | | 2019 |
| Shorts Turf Machinery Ltd | Other services | 2018 |
| SHS Consulting Ltd | Professional & scientific | 2025 |
| Shuffleguds Limited | Wholesale & retail | 2024 |
| Shutter Island Ltd | Professional & scientific | 2026 |
| Shutter Services Ltd | Manufacturing | 2021 |
| Shwan Shawarma Ltd | Hospitality | 2026 |
| Siabid D&P Ltd | Manufacturing | 2024 |
| Siblings Nursery (Beacon) Limited | Health & social care | 2018 |
| Siby Estates Ltd | Real estate | 2025 |
| Sid's Spice Ltd | Hospitality | 2025 |
| Side Cottage Ltd | Real estate | 2024 |
| Sidecar Experience Limited | Administrative & support | 2022 |
| Sidepark Group Ltd | Administrative & support | 2023 |
| Sidewinders LLC UK Limited | Construction | 2017 |
| Sidhesart Ltd | Extraterritorial | 2022 |
| Siege Custom Prints Ltd | Manufacturing | 2026 |
| Siglion Developments LLP | | 2014 |
| Siglion Holdings Limited | Financial services | 2019 |
| Siglion Investments LLP | | 2014 |
| Siglion LLP | | 2014 |
| Siglion Nominee Limited | Real estate | 2014 |
| Signa Care (SHL) Ltd | Administrative & support | 2023 |
| Signa Care Group Ltd | Administrative & support | 2018 |
| Signa Care Liverpool Ltd | Administrative & support | 2023 |
| Signa Care Ltd | Administrative & support | 2022 |
| Signorina Homes Ltd | Real estate | 2023 |
| Signorina Properties Ltd | Real estate | 2022 |
| Sileek Ltd. | Wholesale & retail | 2025 |
| Silivri Pizza Ltd | Hospitality | 2025 |
| Silksoft Limited | Professional & scientific | 1995 |
| Silksworth Pizza Ltd | Hospitality | 2017 |
| Silly Spider Ltd | Administrative & support | 2017 |
| Silva LEX Ltd | Professional & scientific | 2024 |
| Silver Edge Associates Ltd | Administrative & support | 2023 |
| Silverton Carnforth Ltd | Real estate | 2022 |
| Simar Dhillon Limited | Hospitality | 2026 |
| Simars Convenience Ltd | Wholesale & retail | 2021 |
| Simon & SON Ltd | Other services | 2009 |
| Simon Maratty Logistics Ltd | Transport & logistics | 2025 |
| Simon West Interiors Limited | Manufacturing | 1978 |
| Simonstone Lettings Limited | Real estate | 2016 |
| Simpli Financial Solutions Ltd | Financial services | 2015 |
| Simpson Property North East Limited | Real estate | 2022 |
| Simpson Safety Services Limited | Administrative & support | 2016 |
| Sinem Barbers Ltd | Other services | 2022 |
| Sinev Ltd | Financial services | 2022 |
| Singh Brothers PVT Ltd | Wholesale & retail | 2025 |
| Singh Medical Services (NE) Limited | Health & social care | 2010 |
| Singhs Teams Ltd | Wholesale & retail | 2022 |
| Single Source Aviation Global Limited | Transport & logistics | 2022 |
| Single Source Group Limited | Professional & scientific | 2015 |
| Siri's Hub Limited | Hospitality | 2026 |
| Siris Environmental Limited | Professional & scientific | 1998 |
| Siris Flow Inspections Ltd | Professional & scientific | 2001 |
| Sirius Marketing and Consultancy Ltd | Extraterritorial | 2015 |
| SIT 'N' B' Fit Limited | Arts & recreation | 2014 |
| Sitaram Investments Ltd | Real estate | 2021 |
| SIX Futures Ltd | Real estate | 2014 |
| SJ Mechanical Design Limited | Administrative & support | 2011 |
| SJ Paturu Logistics Ltd | Transport & logistics | 2025 |
| SJC Property Investments NE Ltd | Construction | 2023 |
| SJC Utility Services Ltd | Construction | 2019 |
| SJI Traders Ltd | Wholesale & retail | 2023 |
| Sjmartin Engineering Limited | Professional & scientific | 2020 |
| SJP Management Services Ltd | | 2010 |
| SJP Wind Limited | Manufacturing | 2024 |
| SK Building Maintenance Limited | Construction | 2023 |
| SK Events DJ Ltd | Arts & recreation | 2024 |
| Skewers of Delight Ltd | Hospitality | 2025 |