| Sewal Construction Limited | Construction | 2012 |
| SFR Eggs Ltd | Wholesale & retail | 2021 |
| SH & SON Contracts Ltd | Administrative & support | 2025 |
| SH Fuels Limited | Wholesale & retail | 2020 |
| Shakespeare's NW Limited | Wholesale & retail | 2020 |
| Sheerin's Foodmarket Ltd | Wholesale & retail | 2010 |
| Silkroad Synergy Ltd | Wholesale & retail | 2024 |
| Silverhill Foods Holdings Limited | Financial services | 2016 |
| Silverhill Foods Limited | Hospitality | 2012 |
| Silverhill Two Limited | Financial services | 2016 |
| Simms Machinery (NI) Ltd | Wholesale & retail | 2023 |
| Sion Mills Community Complex | Education | 1997 |
| Sion Mills Sport and Leisure Company Ltd | Real estate | 2020 |
| Sj&P Fuels Ltd | Wholesale & retail | 2023 |
| SJK Construction Ltd | Construction | 2007 |
| Slievemore View Management Company Limited | Construction | 2006 |
| SM Pigs Limited | Agriculture & fishing | 2011 |
| SM Property Ireland Ltd | Real estate | 2023 |
| Smcg Ltd | Professional & scientific | 2018 |
| SME Loans Ltd | Financial services | 2020 |
| Smgw Retail Ltd | Wholesale & retail | 2018 |
| Smyth & Young Engineering Ltd | Manufacturing | 2008 |
| SN Truck and Plant Hire Limited | Transport & logistics | 2015 |
| SN Truck and Plant Limited | Manufacturing | 2013 |
| Solid Systems Engineering Ltd | Manufacturing | 2024 |
| Solis Ventus Limited | Manufacturing | 2022 |
| Solitair Unisex Hair Studio Ltd | Other services | 2012 |
| Sollus Cultural Promotions C.I.C. | Arts & recreation | 2013 |
| Sonafox Ltd. | Wholesale & retail | 2021 |
| SPA4 GmbH Ltd | Construction | 2021 |
| Sparkling Equine Ltd | Agriculture & fishing | 2017 |
| Sperrin View Electrical Limited | Energy | 2014 |
| Spire Medical Sleep Diagnostics Limited | Wholesale & retail | 2024 |
| Springhill Park Community Development Association | Other services | 1998 |
| SSB Partners Ltd | Real estate | 2023 |
| ST Mary's Pre-School Cloughcor | Education | 2015 |
| Starlight Bar Limited | Hospitality | 2003 |
| Steady Comps Ltd | Wholesale & retail | 2014 |
| Steadycomps Outlet Ltd | Wholesale & retail | 2020 |
| Stevenson Contracts Limited | Construction | 2016 |
| Stewart Hospitality Ltd | Hospitality | 2025 |
| Stonypath Developments Ltd | Real estate | 1994 |
| Strabane & District Caring Services | Health & social care | 1994 |
| Strabane Attic Ladders Ltd | Construction | 2020 |
| Strabane BID Company Ltd | Other services | 2017 |
| Strabane Cabs Ltd | Transport & logistics | 2011 |
| Strabane Car and Van Ltd | Wholesale & retail | 2016 |
| Strabane Community Project | Health & social care | 1993 |
| Strabane Community Unemployed Group | Education | 1997 |
| Strabane Developments Limited | Construction | 2013 |
| Strabane Garden Depot Ltd | Wholesale & retail | 2020 |
| Strabane Health Improvement Project CIC | Other services | 2012 |
| Strabane Mills Limited | Manufacturing | 1986 |
| Strabane Mortgage Centre Ltd | Financial services | 2015 |
| Strabane Nails Limited | Other services | 2024 |
| Strabane Pest Control Ltd | Administrative & support | 2025 |
| Strabane Property Centre Ltd. | Real estate | 2016 |
| Strabane Services Ltd | Construction | 2018 |
| Strabane Specsavers Limited | Wholesale & retail | 2017 |
| Strabane Wholesales Ltd | Wholesale & retail | 2006 |
| Strabanimal Media Limited | Wholesale & retail | 2019 |
| Straddle Trading Limited | Professional & scientific | 2013 |
| Straken Developments Limited | Households | 2015 |
| Stratex Limited | Construction | 2009 |
| Street Cars Strabane Limited | Transport & logistics | 2018 |
| Stroanbrack Farm Ltd | Agriculture & fishing | 2013 |
| Studio 1 Craft Centre CIC | Wholesale & retail | 2023 |
| Sun Taxis Limited | Transport & logistics | 2015 |
| Sunlit Limited | Wholesale & retail | 2025 |
| Sure WHY NOT? Ltd | Information & communication | 2022 |
| Swiftpay Ltd | Professional & scientific | 2017 |
| Sygol Ltd | Health & social care | 2019 |
| T C Builders NW Limited | Construction | 2014 |
| T R Glass and Glazing Limited | Manufacturing | 1994 |
| T&L Property Ltd | Real estate | 2022 |
| T.Mcsorley Transport Ltd | Transport & logistics | 2025 |
| Taggart Contracts Ltd | Construction | 2014 |
| Tamworth Rentals Limited | Households | 2021 |
| Taxation Consultants Limited | Professional & scientific | 2019 |
| Team Bruisky Limited | Hospitality | 2016 |
| Tech a Chance on IT Training Solutions Ltd | Education | 2022 |
| Tekke Ltd | Hospitality | 2026 |
| Termac Contracts Northwest Limited | Construction | 2013 |
| TH Motors Ltd | Wholesale & retail | 2018 |
| THE Ballers Club Ltd | Wholesale & retail | 2025 |
| THE Bear Run 74 Ltd | Arts & recreation | 2025 |
| THE Bridge Guns and Tackle Limited | Wholesale & retail | 2012 |
| THE Central Bar NW Limited | Hospitality | 2016 |
| THE Cherry Tree Strabane Ltd | Hospitality | 2021 |
| THE Drummond Centre Project Limited | Arts & recreation | 2004 |
| THE Eco Basket Ltd | Hospitality | 2023 |
| THE Food Terrace Limited | Hospitality | 2026 |
| THE Frame Shop Strabane Ltd | Manufacturing | 2025 |
| THE Furniture Liquidator Limited | Wholesale & retail | 2012 |
| THE Furniture Recycling Company Limited | Manufacturing | 2018 |
| THE Hatch Strabane Ltd | Hospitality | 2021 |
| THE Hub Tech Centre Strabane Ltd | Wholesale & retail | 2026 |
| THE Ignite Project CIC | Arts & recreation | 2021 |
| THE Koram Centre, Counselling, Psychotherapy and Psycho Social Support Ltd. | Health & social care | 2006 |
| THE Melmount Chippy Ltd | Hospitality | 2011 |