| Crown & Anchor PUB & Kitchen Limited | Hospitality | 2021 |
| Crown Meadow Court Management Company Limited | Real estate | 2007 |
| Crown of India Curries Limited | Hospitality | 2025 |
| Crucialcare Limited | Other services | 2018 |
| Cryo Blasting UK Ltd | Administrative & support | 2025 |
| CSW Ventures Limited | Financial services | 2025 |
| CT 365 Business Services Limited | Professional & scientific | 2014 |
| Cumberland House Surgery GPF Limited | Professional & scientific | 2013 |
| Cutmaven Ltd | Professional & scientific | 2017 |
| Cyan Labs Ltd | Information & communication | 2019 |
| Cyber Fusion Distribution Services Limited | Information & communication | 2021 |
| Cyber Kiln Ltd | Information & communication | 2019 |
| Cydro Limited | Professional & scientific | 2018 |
| Cynetrix Ltd | Information & communication | 2025 |
| D F C (North West) Limited | Wholesale & retail | 2020 |
| D P Automation Limited | Other services | 2012 |
| D&S on Site Services Ltd | Construction | 2024 |
| D-Wise Technologies UK Limited | Information & communication | 2010 |
| D9COACHING Ltd | Arts & recreation | 2024 |
| DAB Logistics Ltd | Transport & logistics | 2021 |
| DAD Munro Limited | Real estate | 1997 |
| Dairyfields Properties Limited | Real estate | 2025 |
| Dairylink UK Ltd | Hospitality | 2009 |
| Dais Technologies Ltd | Information & communication | 2023 |
| Dapade Limited | Real estate | 2024 |
| Data Conversations Ltd | Information & communication | 2026 |
| Data Science Talent Limited | Administrative & support | 2011 |
| Datel Design and Development Limited | Information & communication | 1993 |
| Datel Direct Limited | Wholesale & retail | 1994 |
| Datel Electronics Limited | Manufacturing | 1985 |
| Datel Holdings Limited | Professional & scientific | 1994 |
| Dave Lees LBC Ltd | Construction | 2025 |
| David a Parker Limited | Wholesale & retail | 2011 |
| David Ashton Hughes Ltd | Extraterritorial | 2024 |
| David James Kelly Limited | Professional & scientific | 2023 |
| Davies Transport (Staffs) Limited | Transport & logistics | 2020 |
| DC Land (Kidsgrove) LLP | | 2009 |
| DCF Estates Limited | Real estate | 2021 |
| DCI Trading Limited | Extraterritorial | 2017 |
| DE Dietrich Process Systems Limited | Professional & scientific | 1993 |
| Debonair Gardens Ltd | Other services | 2018 |
| Decolight Limited | Wholesale & retail | 2006 |
| Deli-Licious Limited | Hospitality | 2025 |
| Dermica Estetica Ltd | Wholesale & retail | 2026 |
| Derventio Social Work Services Limited | Health & social care | 2012 |
| Direct Recruitment (Midlands) Group Ltd | Financial services | 2022 |
| Direct Recruitment (Midlands) Holdings Limited | Administrative & support | 2013 |
| Direct Recruitment (Midlands) Limited | Administrative & support | 1999 |
| Dissident Creative Agency Limited | Professional & scientific | 2022 |
| Distillation Equipment Company Ltd | Manufacturing | 1998 |
| Distinguished Roasts Ltd | Manufacturing | 2023 |
| Djtl Consultants Ltd | Professional & scientific | 2019 |
| DMC Advisory Limited | Financial services | 2013 |
| DMM Support CIC | Health & social care | 2024 |
| Docksey Dawson Holdings Ltd | Financial services | 2024 |
| Docksey Dawson Properties Ltd | Real estate | 2026 |
| Dominic Fleming Ltd. | Administrative & support | 2016 |
| Doneable Limited | Information & communication | 2026 |
| Dosvid Logistics Ltd | Transport & logistics | 2026 |
| Double Dagger Fitness Ltd | Arts & recreation | 2014 |
| Dove Technology Limited | Manufacturing | 2008 |
| DPS Tableware Limited | Wholesale & retail | 2001 |
| DR Automotive Limited | Wholesale & retail | 2013 |
| DR Beth Haycock Educational Psychologist Limited | Education | 2025 |
| DR Contracting Ltd | Information & communication | 2011 |
| DR WAT Psychological Services Limited | Health & social care | 2025 |
| Dragon 2026 Limited | Hospitality | 2026 |
| Dreamair Ltd | Wholesale & retail | 2003 |
| Drsg&Sn Limited | Health & social care | 2023 |
| DST Profiler Limited | Information & communication | 2022 |
| Ducal (International) Limited | Wholesale & retail | 1988 |
| DUCAL-2018 Ltd. | Administrative & support | 2018 |
| Dukes Bailiffs Holdings Limited | Financial services | 2013 |
| Dukes Bailiffs Limited | Administrative & support | 2002 |
| Dunoon Ceramics Holdings Limited | Manufacturing | 2009 |
| DW Genetics Ltd | Agriculture & fishing | 2025 |
| DW Luxe Properties Ltd | Real estate | 2024 |
| Dynamic Orthopaedics Limited | Wholesale & retail | 2023 |
| E Plant Limited | Administrative & support | 2026 |
| E.Quality Training Limited | Education | 2004 |
| Earl & Associates Ltd | Professional & scientific | 2023 |
| EBP Stafford Ltd | Transport & logistics | 2025 |
| Edgehog Limited | Information & communication | 2013 |
| Edgespace Limited | Real estate | 2001 |
| Edgestone Limited | Real estate | 2024 |
| Efbkl Limited | Wholesale & retail | 2025 |
| Efficsant Solutions Limited | Information & communication | 2014 |
| Egret Care Ltd | Health & social care | 2024 |
| Egret Homes CIC | Health & social care | 2025 |
| Eisiam Limited | Real estate | 2018 |
| Elbaek Properties Limited | Construction | 2014 |
| Electrical Solution Ltd | Construction | 2007 |
| Elelte Limited | Wholesale & retail | 2022 |
| ELEV8 Aviation Limited | Professional & scientific | 2005 |
| Elicare Limited | Professional & scientific | 2012 |
| Elite Site Engineering Services Ltd | Professional & scientific | 2024 |
| Elmhurst House PRE School Limited | Health & social care | 2013 |
| Elmwell UK Ltd | Education | 2024 |
| ELS Holdings Limited | Financial services | 2023 |
| Embedded Science Limited | Information & communication | 2012 |