| Denzoo Limited | Wholesale & retail | 2021 |
| DEP Products Ltd | Construction | 2013 |
| Deploy Ecommerce Limited | Information & communication | 2010 |
| Derama Limited | Health & social care | 2025 |
| Derby ATE Services Limited | Information & communication | 2003 |
| Derby House Developments Ltd | Real estate | 2023 |
| Derby House Homes Ltd | Real estate | 2025 |
| Dere Pinar Limited | Hospitality | 2023 |
| Derek Fower Transport Limited | Transport & logistics | 2022 |
| Dermal Luxe Ltd | Health & social care | 2024 |
| Dermal Technology Laboratory Ltd | Professional & scientific | 2007 |
| Dermamoss Limited | Wholesale & retail | 1974 |
| Dermique Aesthetics Ltd | Other services | 2026 |
| Dermody Investments Limited | Real estate | 2019 |
| Desem Engineering Limited | | 1978 |
| Desi Brew Ltd | Hospitality | 2025 |
| Desi Dera Longton Limited | Hospitality | 2020 |
| Desi Dhaba Stoke Limited | Hospitality | 2026 |
| Desi Kitchen Curry House Ltd | Hospitality | 2025 |
| Desi Moments Limited | Hospitality | 2023 |
| Desi Smash Burger Ltd | Hospitality | 2025 |
| Desi Spice Catering Ltd | Hospitality | 2018 |
| Desi'Z Cafe Ltd | Hospitality | 2025 |
| Design a Wall Ltd | Wholesale & retail | 2024 |
| Design Bundles Limited | Wholesale & retail | 2016 |
| Design Engineering Limited | Manufacturing | 2016 |
| Design GUY Limited | Wholesale & retail | 2023 |
| Design Stock Holdings Limited | Financial services | 2018 |
| DESIGN21 Architecture Limited | Professional & scientific | 2017 |
| Designer Menswear Trading Ltd | Wholesale & retail | 2019 |
| Designer Sport & Leisure Limited | Wholesale & retail | 2001 |
| Desire Bar Ltd | Wholesale & retail | 2023 |
| Desire Properties Ltd | Real estate | 2019 |
| DESOL8 Automation Ltd | Information & communication | 2025 |
| Dessert Lounge Limited | Manufacturing | 2025 |
| Dessert Street Stoke Ltd | Hospitality | 2023 |
| Destination Fitness Holdings Limited | Arts & recreation | 2021 |
| Destination Strength & Fitness Limited | Arts & recreation | 2021 |
| Detail and Customs Ltd | Wholesale & retail | 2019 |
| Detailed UK Installation Ltd | Construction | 2023 |
| Determination Delivers Ltd | Real estate | 2020 |
| Deutsche Doktors Ltd | Administrative & support | 2016 |
| Developers Care Limited | Information & communication | 2025 |
| Developing Menus Ltd | Hospitality | 2024 |
| Developing `U` Limited | Education | 2003 |
| Developments for Tomorrow Ltd | Construction | 2019 |
| Deveyre Limited | Information & communication | 2014 |
| DEVICES1 Ltd | Wholesale & retail | 2020 |
| Devine IT Ltd | Information & communication | 2026 |
| Deviprox Ltd | Information & communication | 2025 |
| Devonshire Dale Ltd | Real estate | 2025 |
| Devoxa Limited | Information & communication | 2020 |
| Dewon Construction Ltd | Construction | 2024 |
| DEX Financials Ltd | Administrative & support | 2022 |
| Dexterous Solution Ltd | Transport & logistics | 2024 |
| DFH Property Developments Limited | Construction | 2018 |
| DG Site Services Limited | Manufacturing | 2011 |
| DG Travels Limited | Transport & logistics | 2018 |
| DGH Decorators Limited | Construction | 2004 |
| DGM Plumbing & Heating Ltd | Construction | 2025 |
| DGS Planning Services Limited | Professional & scientific | 2013 |
| Dgs-Recovery Ltd | Transport & logistics | 2024 |
| DH & DP Northwood Stoke Limited | Real estate | 2022 |
| DH2 Technology Ltd | Information & communication | 2026 |
| Dhana Lakshmi Limited | Real estate | 2021 |
| Dhana Lakshmi Medical Ltd | Health & social care | 2022 |
| Dhap Properties Co Ltd | Real estate | 2025 |
| Dharshanodiyaa School of Bharathanatiyam Ltd | Education | 2020 |
| DHB Property Ltd | Real estate | 2018 |
| Dhir Medical Services Limited | Health & social care | 2015 |
| DHR Commerce Limited | Wholesale & retail | 2025 |
| DI Lucca Ltd | Professional & scientific | 2024 |
| Diacheo Limited | Information & communication | 2021 |
| Diagnolink Ltd | Wholesale & retail | 2026 |
| Dialectyx Solutions Limited | Information & communication | 1995 |
| Dialogia Ltd | Professional & scientific | 2023 |
| Diamond Car Mats Ltd | Wholesale & retail | 2018 |
| Diamond Car Wash (Stoke) Ltd | Other services | 2017 |
| Diamond Convenience Store Ltd | Wholesale & retail | 2020 |
| Diamond Freight Limited | Transport & logistics | 2002 |
| Diamond Home & Fashion Ltd | Wholesale & retail | 2025 |
| Diamond Properties SOT Limited | Real estate | 2025 |
| Diamondfix Network Limited | Wholesale & retail | 2026 |
| Diana&M Ltd | Transport & logistics | 2025 |
| Diaspora Lounge Ltd | Hospitality | 2025 |
| Dickos Preloved Ltd | Wholesale & retail | 2025 |
| Dido Property Holdings Ltd | Real estate | 2026 |
| Didu Property Ltd | Real estate | 2023 |
| Diego Henry Limited | Transport & logistics | 2025 |
| Diegrave Holdings Limited | Manufacturing | 1971 |
| DIG Deep Education Ltd | Education | 2019 |
| Digger Hire Direct Ltd | Administrative & support | 2024 |
| Diggers & Daisies Ltd | Wholesale & retail | 2026 |
| Digi Enterprise Ltd | Wholesale & retail | 2025 |
| Digi UK Solutions Limited | Administrative & support | 2024 |
| Diginers Ltd | Information & communication | 2022 |
| Digipai Digital Marketing & AI Solutions Limited | Information & communication | 2025 |
| Digital AD Consultant Ltd | Wholesale & retail | 2024 |
| Digital Bloom Studio Ltd | Professional & scientific | 2025 |
| Digital Ceramic Systems Limited | Manufacturing | 2000 |