| Churnet Valley Railway (1992) PLC | Transport & logistics | 1992 |
| CI Properties Limited | Real estate | 2023 |
| Ciax Ltd | Other services | 2025 |
| Cici Lulu Limited | Financial services | 2025 |
| CIP Estates Limited | Real estate | 1979 |
| Ciprian Transport Ltd | Transport & logistics | 2018 |
| Ciragan Investments Limited | Professional & scientific | 2006 |
| Circadian Imports Ltd | Wholesale & retail | 2015 |
| Cispro Ltd | Information & communication | 2025 |
| Citizens Advice North Staffordshire Ltd | Health & social care | 1989 |
| Cito Cimo Quest Limited | Real estate | 2017 |
| Cito Cimo Residence Limited | Real estate | 2019 |
| Cito Cimo Sourcing Limited | Real estate | 2018 |
| Citus Technology UK Ltd | Information & communication | 2021 |
| City B Marquees Ltd | Administrative & support | 2000 |
| City Cabs, Buses & Coaches Ltd | Transport & logistics | 2011 |
| City Car Wash Stoke Ltd | Administrative & support | 2023 |
| City Clinic Limited | Other services | 2024 |
| City Construction Staffordshire Limited | Administrative & support | 2026 |
| City Discount Ltd | Wholesale & retail | 2026 |
| City Heating Ltd | Construction | 2015 |
| City Learning Trust | Education | 2011 |
| City Mobile Tyres Limited | Wholesale & retail | 2025 |
| City of Stoke Athletics Club | Arts & recreation | 2020 |
| City Social Care Services Limited | Health & social care | 2023 |
| City Transport and Recovery Limited | Administrative & support | 2025 |
| City Tyres Stoke Limited | Wholesale & retail | 2023 |
| City Window Services Ltd | Construction | 2015 |
| City Wise Property Management Ltd | Real estate | 2019 |
| Cityhigher Limited | Real estate | 2000 |
| Citylink Cars Birmingham Ltd | Transport & logistics | 2023 |
| Cityrise Properties Limited | Real estate | 2025 |
| Cityy Cafe Ltd | Hospitality | 2020 |
| Civil Edge CIC | Professional & scientific | 2025 |
| Civil Enforcement Association Limited | Other services | 2011 |
| Civil Engineering Academy Ltd | Education | 2025 |
| Civvystreet Limited | Wholesale & retail | 2016 |
| CJ & Co Consult Ltd | Professional & scientific | 2022 |
| CJ Electrical (SOT) Limited | Manufacturing | 2006 |
| CJ Hartley Brothers Ltd | Wholesale & retail | 2019 |
| CJ Marshall Consulting Ltd. | Information & communication | 2017 |
| CJ Newcastle Limited | Hospitality | 2026 |
| CJ Prospecting Limited | Information & communication | 2023 |
| CJ Room Ltd | Hospitality | 2014 |
| CJ Transport (UK) Ltd | Transport & logistics | 2008 |
| CJC Electrics Ltd | Construction | 2025 |
| CJD Properties (Staffordshire) Limited | Real estate | 2021 |
| CJH Bars Ltd | Hospitality | 2019 |
| CJM Roofing & Chimneys Ltd | Construction | 2025 |
| CJS Building Services (Cheshire) Limited | Construction | 2026 |
| CK Courier Services Ltd | Transport & logistics | 2022 |
| CK Landscapes Ltd | Administrative & support | 2026 |
| CKB Building Contractors Ltd | Construction | 2023 |
| CKF Services (UK) Ltd | Wholesale & retail | 2016 |
| CL Property Developments Limited | Construction | 2018 |
| CLA Midlands Finishing Limited | Manufacturing | 2025 |
| Claims Assist UK (SOT) Limited | Administrative & support | 2015 |
| Clamar Ltd | Wholesale & retail | 2021 |
| Clarke Auto Electrics Ltd | Construction | 2020 |
| Clarke Automotive Garage Services Ltd | Wholesale & retail | 2014 |
| Clarke Metal Services Holdings (Cheshire) Limited | Financial services | 2024 |
| Clarke Metal Services Limited | Wholesale & retail | 1999 |
| Clarke Unique Structures Ltd | Manufacturing | 2023 |
| Clarke Upholstery Limited | Manufacturing | 2018 |
| Clarke's Autocentre Limited | Wholesale & retail | 2015 |
| Clarksparks Ltd | Professional & scientific | 2018 |
| Class Roots Consultancy Ltd | Education | 2019 |
| Classic Catering (Leek) Ltd | Hospitality | 2018 |
| Classic Streetwears Limited | Wholesale & retail | 2025 |
| Classical Brands Ltd | Wholesale & retail | 2001 |
| Classy Developments Ltd | Real estate | 2025 |
| Claudiu Delivery Limited | Transport & logistics | 2025 |
| Claybody Theatre | Arts & recreation | 2015 |
| Claycoded Ltd | Professional & scientific | 2026 |
| Clayton Cleaning Solutions Limited | Administrative & support | 2016 |
| CLC Professional Contracts Ltd | Construction | 2014 |
| Clean Daze Ltd | Other services | 2026 |
| Clean Food Kitchen Ltd | Hospitality | 2019 |
| Clean U Skincare Limited | Wholesale & retail | 2018 |
| Cleanergi Ltd | Administrative & support | 2024 |
| Cleanforce Contracting Limited | Administrative & support | 1974 |
| Cleaning and Organising UK Ltd | Administrative & support | 2024 |
| Cleaningcgm Ltd | Administrative & support | 2022 |
| Cleanpaintrent Ltd | Construction | 2026 |
| Clear Brew Cheshire & Cheshire East Ltd | Administrative & support | 2021 |
| Clear ETD Limited | Information & communication | 2019 |
| Clear Feeling Clothings Ltd | Wholesale & retail | 2024 |
| Clear Path Data Ltd | Information & communication | 2024 |
| Clear Path Pressure Ltd | Administrative & support | 2025 |
| Clear Route Driving Ltd | Education | 2026 |
| Clear Sky Hospitality Ltd | Hospitality | 2022 |
| Clear Vision Fleet Installations Ltd | Wholesale & retail | 2022 |
| Clearance CC Ltd | Wholesale & retail | 2025 |
| Clearer Windows Ltd | Administrative & support | 2025 |
| Clearpath BSA Compliance Ltd | Construction | 2026 |
| Clearquest (UK) Limited | Administrative & support | 2010 |
| Clefemad Services Ltd | Information & communication | 2025 |
| Clements Care Limited | Health & social care | 2017 |
| Clergy Ltd | Information & communication | 2017 |
| Clerking & Compliance Ltd | Financial services | 2026 |