| Rookery Waste Removal Ltd | Wholesale & retail | 2021 |
| Roomacres 124 Ltd | Administrative & support | 2025 |
| Rooms to LET Shelton Ltd | Real estate | 2026 |
| Rooms to Roost Ltd | Households | 2015 |
| Rooshh Ltd | Wholesale & retail | 2025 |
| Rooted Mirror Harmony AI Ltd | Information & communication | 2026 |
| Roots Recruiters Limited | Administrative & support | 2024 |
| Roots Stoke Limited | Hospitality | 2026 |
| Roots to Tips Trees Ltd | Administrative & support | 2025 |
| Rootsmiths Limited | Education | 2025 |
| Rosamund Beauty Limited | Wholesale & retail | 2018 |
| Rose & Winn Properties Ltd | Real estate | 2026 |
| Rose Distribution Ltd | Wholesale & retail | 2020 |
| Rose Fast Food Ltd | Hospitality | 2021 |
| Rose Grill Stoke Ltd | Hospitality | 2025 |
| Rose Petals and Rice Ltd | Professional & scientific | 2023 |
| Rose Stuart Esther Group Ltd | Professional & scientific | 2023 |
| Rose's Refills Limited | Wholesale & retail | 2022 |
| Roseacre 1959 Limited | Extraterritorial | 2014 |
| Rosebuds for Arthur Ltd | Other services | 2022 |
| Rosegold Property Investments UK Limited | Real estate | 2022 |
| Rosehill Lodges Ltd | Hospitality | 2022 |
| Rosemond Art Group Ltd | Information & communication | 2018 |
| Rosemount Transport Investments Ltd | Professional & scientific | 2021 |
| Rosette Garden Products Limited | Manufacturing | 2015 |
| Rosie Chidlow Ltd | Health & social care | 2021 |
| Ross Engineers Limited | Professional & scientific | 2001 |
| Ross Roofing & Solar Ltd | Construction | 2025 |
| Rosy Cheeks Nurseries Ltd | Health & social care | 2010 |
| Rotana Restaurant Ltd | Hospitality | 2026 |
| Rotisserie (Trentham) Limited | Hospitality | 2009 |
| Rotisserie&Gyros Ltd | Hospitality | 2024 |
| Round Meadows Ltd | Arts & recreation | 2019 |
| Roundwell Estates Limited | Real estate | 2020 |
| Roundwell Holdings Limited | Professional & scientific | 2021 |
| ROUTE2SUSTAINABILITY Limited | Administrative & support | 2011 |
| ROUTE786 Ltd | Information & communication | 2025 |
| Rovisini Properties Ltd | Real estate | 2025 |
| ROW Houses Stoke Limited | Real estate | 2018 |
| Rowlands Investments (UK) Ltd | Construction | 2019 |
| Rowlinson Fabrications Ltd | Agriculture & fishing | 2021 |
| Rownall Developers Limited | Construction | 2024 |
| ROX Wellbeing Ltd | Other services | 2025 |
| Roxberg Holdings Limited | Financial services | 2017 |
| Roxktransport Ltd | Transport & logistics | 2021 |
| ROY Beech (Surfacing) Limited | Professional & scientific | 2002 |
| ROY Head Property Company Ltd | Other services | 2002 |
| ROY Kirkham & Co. Limited | Manufacturing | 1976 |
| ROY Kirkham Tableware Limited | Administrative & support | 2006 |
| Roy's Convenience Ltd | Wholesale & retail | 2024 |
| Roy's Haulage Limited | Transport & logistics | 2022 |
| Royal Stafford China Limited | Manufacturing | 1980 |
| Royal Voluntary Service | Wholesale & retail | 1990 |
| Royal Voluntary Service (Trading Company) Limited | Wholesale & retail | 2023 |
| Royal Voluntary Service Meals on Wheels Limited | Hospitality | 1993 |
| Royale Boiler Services Limited | Manufacturing | 2018 |
| Royale House of Foods Limited | Wholesale & retail | 2025 |
| Royale Weddings and Film Production Ltd. | Information & communication | 2015 |
| Rozey Balti Restaurant Ltd | Hospitality | 2025 |
| RP Airmovements Ltd | Manufacturing | 2026 |
| RP Motor Sales Ltd | Wholesale & retail | 2026 |
| RP Software Ltd | Information & communication | 2025 |
| RPA Assets Limited | Wholesale & retail | 2023 |
| RPA Stoke Ltd | Wholesale & retail | 2020 |
| Rpgee Media Limited | Information & communication | 2014 |
| Rpsw Ltd | Real estate | 2021 |
| RPZ Limited | Real estate | 2014 |
| RQ Construction Ltd | Construction | 2017 |
| RR Assessments & Training Limited | Education | 2019 |
| RR Band Ltd | Arts & recreation | 2021 |
| RR Inno BI Solutions Limited | Information & communication | 2025 |
| RR Travels Midlands Ltd | Transport & logistics | 2025 |
| RRB Radiology Services Ltd | Health & social care | 2024 |
| Rremotely Ltd | Education | 2025 |
| RRR Investments Limited | Real estate | 2026 |
| Rrsh Management Services Limited | Public administration | 2019 |
| RS Autos Stoke Ltd | Wholesale & retail | 2021 |
| RS Barber (Stoke) Ltd | Other services | 2024 |
| RS Design & Build (Staffs) Ltd | Construction | 2023 |
| RS Dispatch Ltd | Transport & logistics | 2024 |
| RS Financial Limited | Financial services | 2015 |
| RS Khera Ltd | Wholesale & retail | 2022 |
| RS Medical Accountancy Ltd | Professional & scientific | 2011 |
| RS Medical Assessments Limited | Health & social care | 2020 |
| RS Pro Electrical Ltd | Construction | 2024 |
| RS Renewable Energy Limited | Construction | 2019 |
| RSA 2024 Ltd | Transport & logistics | 2024 |
| RSB Access Ltd | Construction | 2021 |
| RSD Joinery Ltd | Construction | 2022 |
| RSJ Hygiene Therapy Ltd | Health & social care | 2024 |
| RSK Building Ltd | Extraterritorial | 2022 |
| RSK Property Ltd | Real estate | 2020 |
| Rska Developments Limited | Real estate | 2026 |
| RSR Publishing Limited | Information & communication | 2025 |
| RT Logistica Ltd | Transport & logistics | 2020 |
| Rt&B Trading Ltd | Wholesale & retail | 2024 |
| RTB Trading Ltd | Wholesale & retail | 2025 |
| RTD TRANS2 Ltd | Transport & logistics | 2025 |
| RTD. Trans Ltd | Transport & logistics | 2018 |
| RTS Essentials Ltd | Wholesale & retail | 2024 |