| Daud & Sons Ltd | Real estate | 2023 |
| Dave Charnley Photography Limited | Professional & scientific | 2012 |
| Dave Hughes Driver Training Limited | Education | 2017 |
| Dave Sangha Locum Services Limited | Wholesale & retail | 2007 |
| David Copley Inspection Ltd | Professional & scientific | 2022 |
| David Earl Plant Services Ltd | Construction | 2025 |
| David J F Services UK Ltd | Construction | 2006 |
| David Penrice Project Management Services Limited | Professional & scientific | 2015 |
| David Prime Leisure Limited | Professional & scientific | 2004 |
| David Rice Services Ltd | Manufacturing | 2016 |
| David Snowdon Brand Management Limited | Professional & scientific | 2009 |
| David Thomas Offshore Services Limited | Energy | 2019 |
| Davidpmellor Limited | Professional & scientific | 2019 |
| Davidsons Paving and Groundworks Limited | Administrative & support | 2020 |
| Davies Care Group Ltd | Health & social care | 2022 |
| Davies Tracey Limited | Professional & scientific | 2009 |
| Dawson Electrical (North East) Limited | Construction | 2009 |
| DAX Engineering Limited | Professional & scientific | 2019 |
| Daynight Care Ltd | Health & social care | 2025 |
| DB & LB Car Wash Ltd | Administrative & support | 2024 |
| DB Rigging & Lifting Limited | Professional & scientific | 2019 |
| DC Infrastructure Services Limited | Construction | 2024 |
| DCR Wind Turbine Techs Limited | Manufacturing | 2018 |
| DDM Commercial Lettings Ltd | Real estate | 2025 |
| DE Thexton Waller Limited | Real estate | 2023 |
| DE'90S Ltd | Real estate | 2021 |
| Deal Sorcerers Ltd | Administrative & support | 2025 |
| Dear Doggo Ltd | Wholesale & retail | 2023 |
| Deborah Bailey-Knibbs Ltd | Hospitality | 2016 |
| Debrohn Limited | Professional & scientific | 2011 |
| Debs Properties (NE) Ltd | Real estate | 2026 |
| Debytes Ltd | Wholesale & retail | 2025 |
| Deen Medical Services Limited | Real estate | 2013 |
| Deepx Subsea Ltd | Professional & scientific | 2021 |
| Degetas Limited | Professional & scientific | 2025 |
| Delamere Place Management Company Limited | Real estate | 2005 |
| Delavogue Ltd | Wholesale & retail | 2023 |
| Delhi Express Northeast Limited | Hospitality | 2024 |
| Delhi Express Oxbridge Ltd. | Hospitality | 2017 |
| DELISH9JASPICE Ltd | Hospitality | 2020 |
| Delivery Inc. Limited | Transport & logistics | 2012 |
| Dell'Aquila Holdings Limited | Financial services | 2025 |
| Delta Building Supplies Ltd | Manufacturing | 2024 |
| Delta Matrix Ltd | Professional & scientific | 2011 |
| Delta Reclamation Limited | Water & waste | 2006 |
| Delta Recycling Limited | Water & waste | 2005 |
| Deluxe DETAILING786 Limited | Extraterritorial | 2024 |
| Deluxe Developments (AD) Ltd | Real estate | 2024 |
| Dementianet CIC | Information & communication | 2024 |
| Demeter Limited | Professional & scientific | 2007 |
| Denco Waste Solutions Limited | Water & waste | 2025 |
| Denizen Impex Ltd | Wholesale & retail | 2024 |
| Dennis Harley Developments Ltd | Real estate | 2004 |
| Dennis Riley & Co Limited | Professional & scientific | 2017 |
| Deny's Gym Limited | Arts & recreation | 2009 |
| Dermapharm Aesthetics Ltd | Health & social care | 2016 |
| Desecon Ltd | Professional & scientific | 2022 |
| Designed by John Walker Ltd | Information & communication | 2026 |
| Destinworld Publishing Ltd | Information & communication | 2008 |
| Detailed Decor Limited | Construction | 2017 |
| Devitt Dhillon Properties Ltd | Real estate | 2021 |
| Dewpoint Energy Services Limited | Professional & scientific | 2011 |
| DEX PUB Co Ltd | Hospitality | 2022 |
| Dexshire Ltd | Professional & scientific | 2025 |
| DF Design Solutions Limited | Other services | 2012 |
| DF Tech Consulting Ltd | Information & communication | 2024 |
| DFB Joinery Limited | Construction | 2016 |
| DFD Management Consultants Limited | Professional & scientific | 1991 |
| DG Optics UK Ltd | Information & communication | 2018 |
| DGB Consultants Limited | Professional & scientific | 2021 |
| Dgjoinerysolutions Ltd | Construction | 2021 |
| DGL Hyperbaric Consultancy Ltd | Professional & scientific | 2025 |
| DGL Plant Hire Limited | Administrative & support | 2024 |
| DH Plumbing and Heating Solutions Ltd | Construction | 2025 |
| DH Renewable Services Ltd | Professional & scientific | 2026 |
| DH4 Ques Restaurant Limited | Hospitality | 2023 |
| DI Faye Consulting Ltd | Professional & scientific | 2024 |
| DI International Ltd | Professional & scientific | 2006 |
| Di-Decor Limited | Professional & scientific | 2025 |
| Diamond Living Limited | Hospitality | 2018 |
| Diamond Nail T Limited | Health & social care | 2026 |
| Diana Wears Ltd | Wholesale & retail | 2021 |
| Dibbin Estates & Equipment Limited | Administrative & support | 2010 |
| Dickens Self Storage Limited | Real estate | 2005 |
| Dickens Warehousing Limited | Real estate | 2007 |
| Digibuild Limited | Professional & scientific | 2021 |
| Digicost Ltd | Information & communication | 2025 |
| DIGISOL180 Ltd | Information & communication | 2025 |
| Digital Generation Limited | Professional & scientific | 2019 |
| Digital Readiness & Intelligent Systems Ltd | Information & communication | 2023 |
| Digital Shark Limited | Information & communication | 2008 |
| Digital Templating Ltd | Manufacturing | 2018 |
| Digitwinz Ltd | Professional & scientific | 2018 |
| Dimension Business Intelligence Limited | Information & communication | 2012 |
| Dingaling Ltd | Hospitality | 2024 |
| Direct Line Supplies Limited | Hospitality | 2001 |
| Direct Property Renovations Limited | Construction | 2019 |
| Direct Property Rentals (NE) Limited | Real estate | 2020 |
| Direct Sales NE Ltd | Wholesale & retail | 2019 |
| Discount Express North East Ltd | Wholesale & retail | 2023 |